公开(公告)号：US20250115866A1

公开(公告)日：2025-04-10

申请号：US18832346

申请日：2023-01-20

Applicant: HIROSHIMA UNIVERSITY ,  ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Masayuki SHIMADA ,  Takashi UMEHARA ,  Noriyasu ISHIKAWA ,  Takashi TAKIJIRI

IPC: C12N5/076

Abstract: The purpose of the present invention is to provide sperm having high motility. The present invention is a composition for treating sperm that comprises medium for mesenchymal stem cells. This composition for treating sperm is used as a sperm preparing solution, a sperm diluting solution, a sperm storage solution, an artificial insemination solution, an in vitro fertilization solution, a solution for improving sperm motility, or a solution for retaining sperm fertilizing capabilities. Additionally, the medium for mesenchymal stem cells contained in the composition for treating sperm is preferably a serum-free medium.

公开(公告)号：US20230321127A1

公开(公告)日：2023-10-12

申请号：US18044089

申请日：2021-09-07

Applicant: MIRAILAB BIOSCIENCE INC. ,  HIROSHIMA UNIVERSITY

Inventor： Megumi TANAKA ,  Tsunemaru TANAKA ,  Masayuki SHIMADA

IPC: A61K31/706 ,  A61K31/4745 ,  A61P15/08

CPC classification number: A61K31/706 ,  A61K31/4745 ,  A61P15/08

Abstract: [PROBLEM] To provide a sperm motility improvement agent that is highly safe and may effectively improve sperm motility.
[SOLUTION] A sperm motility improvement agent comprising nicotinamide mononucleotide as an active ingredient.

公开(公告)号：US20250115865A1

公开(公告)日：2025-04-10

申请号：US18729482

申请日：2023-01-20

Applicant: Hiroshima University

Inventor： Masayuki SHIMADA ,  Takashi UMEHARA

IPC: C12N5/076 ,  C12N5/071

Abstract: In a method of preparing mammalian sperm, mammalian sperm are cultured in a medium at a pH of 7.7 to 7.9 containing a TLR7 ligand, to induce acrosome reaction of Y-chromosome-bearing sperm, to obtain a sperm population rich in X-chromosome-bearing sperm retaining the acrosome. By subjecting the sperm population to artificial insemination or in vitro fertilization, gender preselection for obtaining male offspring is possible.