公开(公告)号：US11464956B2

公开(公告)日：2022-10-11

申请号：US16488456

申请日：2018-02-20

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kazuya Machida ,  Shinpei Nishimura ,  Seiji Tokumoto

IPC: A61M37/00 ,  A61K9/00 ,  A61K9/70

Abstract: A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating layer formed on the microneedles, wherein a length of the microneedles is 300 to 500 μm, the microneedles are disposed on the substrate at a density of 28 to 80 needles/cm2, and the coating layer comprises a biologically active substance. The microneedle device allows the skin irritation caused by administration of an agent to be reduced.

公开(公告)号：US09775799B2

公开(公告)日：2017-10-03

申请号：US14766893

申请日：2014-02-12

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takuya Sugahara ,  Kazuya Machida

IPC: A61K38/00 ,  A61K9/00 ,  A61K47/12 ,  A61K47/18 ,  A61L31/16 ,  A61M5/32 ,  A61K47/02 ,  A61M37/00

CPC classification number: A61K9/0021 ,  A61K38/00 ,  A61K47/02 ,  A61K47/12 ,  A61K47/183 ,  A61L31/16 ,  A61L2300/214 ,  A61M5/329 ,  A61M37/0015 ,  Y02A50/389

Abstract: Disclosed is a microneedle coating composition comprising a physiologically active substance (excluding Japanese encephalitis vaccine antigen), a basic amino acid, and an acid, wherein the mole number of the acid for one mole of the basic amino acid is larger than 1/(N+1) and less than 2, where N represents the valence of the acid.

公开(公告)号：USD754333S1

公开(公告)日：2016-04-19

申请号：US29470047

申请日：2013-10-17

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Designer： Seiji Tokumoto ,  Makoto Ogura ,  Kazuya Machida

公开(公告)号：US09993549B2

公开(公告)日：2018-06-12

申请号：US15032718

申请日：2014-10-30

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Seiji Tokumoto ,  Kazuya Machida ,  Nao Kurokawa ,  Rie Namiki

IPC: A61K39/39 ,  A61K9/08 ,  A61K9/00 ,  A61K47/10 ,  A61K9/70 ,  A61K39/00

CPC classification number: A61K39/39 ,  A61K9/0014 ,  A61K9/0021 ,  A61K9/08 ,  A61K9/7023 ,  A61K39/0008 ,  A61K47/10 ,  A61K2039/54 ,  A61K2039/55511

Abstract: An adjuvant composition of the present invention contains lauryl alcohol and propylene glycol. Contents of the lauryl alcohol and the propylene glycol are 0.5 to 25% by mass and 8.0 to 99.5% by mass, relative to the total mass of the adjuvant composition, respectively. The lauryl alcohol is dissolved, and the adjuvant composition is used for transdermal or transmucosal administration.

公开(公告)号：US09849170B2

公开(公告)日：2017-12-26

申请号：US14766922

申请日：2014-02-12

Applicant: HISAMITSU PHARMACEUTICAL CO., INC. ,  THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE

Inventor： Kazuya Machida ,  Seiji Tokumoto ,  Kazuyoshi Kaminaka ,  Yuji Ishikawa

IPC: A61K38/00 ,  A61K39/12 ,  A61K47/12 ,  A61K9/00 ,  A61K47/18 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K39/12 ,  A61K9/0021 ,  A61K47/12 ,  A61K47/183 ,  A61K2039/54 ,  C12N7/00 ,  C12N2770/24134 ,  Y02A50/39

Abstract: Disclosed is a microneedle coating composition comprising a Japanese encephalitis vaccine antigen, a basic amino acid, and an acid, wherein the mole number of the acid for one mole of the basic amino acid is larger than 1/(N+1) and less than 2, where N represents the valence of the acid.