公开(公告)号：US12233156B2

公开(公告)日：2025-02-25

申请号：US17253311

申请日：2019-06-20

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryota Hori ,  Shinpei Nishimura

IPC: A61M37/00 ,  A61K9/00 ,  A61K31/4174 ,  A61K47/36

Abstract: The present invention aims to manufacture a microneedle device capable of carrying and administering a larger amount of biologically active substance per one microneedle. One aspect of the present invention is a method of manufacturing a microneedle device comprising coating microneedles with a coating liquid, wherein the coating liquid comprises a biologically active substance and a sulfated polysaccharide. The microneedle device manufactured by such a method comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprises a biologically active substance and a sulfated polysaccharide.

公开(公告)号：US11464956B2

公开(公告)日：2022-10-11

申请号：US16488456

申请日：2018-02-20

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kazuya Machida ,  Shinpei Nishimura ,  Seiji Tokumoto

IPC: A61M37/00 ,  A61K9/00 ,  A61K9/70

Abstract: A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating layer formed on the microneedles, wherein a length of the microneedles is 300 to 500 μm, the microneedles are disposed on the substrate at a density of 28 to 80 needles/cm2, and the coating layer comprises a biologically active substance. The microneedle device allows the skin irritation caused by administration of an agent to be reduced.

公开(公告)号：US10828480B2

公开(公告)日：2020-11-10

申请号：US15756234

申请日：2016-08-19

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Shinpei Nishimura ,  Seiji Tokumoto ,  Masafumi Ono

IPC: A61M37/00

Abstract: An applicator according to one embodiment includes a housing having a tubular shape with one closed end, and configured to house an elastic member and a piston plate for transmitting biasing force of the elastic member to the microneedles, and release means configured to release the piston plate engaged in a manner resisting against the biasing force of the elastic member in the housing, to cause the piston plate to move toward an opening of the housing along an axial direction of the housing. The release means is configured, when the release means releases the engagement of the piston plate by moving toward the housing in the axial direction, to transmit force in a direction toward the opening to the housing.

公开(公告)号：US11116955B2

公开(公告)日：2021-09-14

申请号：US16488450

申请日：2018-02-20

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Toru Kobayashi ,  Toshiyuki Matsudo ,  Shinpei Nishimura ,  Seiji Tokumoto ,  Tetsuji Kuwahara

IPC: A61M37/00

Abstract: A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.

公开(公告)号：US10086183B2

公开(公告)日：2018-10-02

申请号：US15032709

申请日：2014-11-04

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Shunsuke Arami ,  Shinpei Nishimura ,  Seiji Tokumoto ,  Makoto Ogura

IPC: A61M37/00

Abstract: An applicator is configured to transfer an active ingredient into a body through skin by a puncture in the skin with microneedles. The applicator includes a piston plate that is provided with a first protrusion part and second protrusion parts on a lower surface side of a main body of the piston plate. The microneedles are provided on a surface of the first protrusion part. The second protrusion parts are provided in a periphery of the first protrusion part while spaced apart from the first protrusion part.

公开(公告)号：US20150157840A1

公开(公告)日：2015-06-11

申请号：US14407258

申请日：2013-06-11

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kazuya Kominami ,  Shinpei Nishimura ,  Seiji Tokumoto ,  Makoto Ogura ,  Toshiyuki Matsudo ,  Naoki Yamamoto

IPC: A61M37/00 ,  A61N2/00 ,  A61N1/32

CPC classification number: A61M37/0015 ,  A61M37/0092 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61N1/325 ,  A61N2/002 ,  A61N2/004

Abstract: A microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet substantially along a principal surface of the sheet. The sheet is bent to raise the microneedles from the principal surface, and the raised microneedles pierce a skin.

Abstract translation: 根据一个实施方案的微针片包括形成在基本上沿着片材的主表面的片材上的多个微针。 弯曲片从主表面抬起微针，凸起的微针刺穿皮肤。

公开(公告)号：US11130148B2

公开(公告)日：2021-09-28

申请号：US14894397

申请日：2014-05-29

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Eiji Hashimoto ,  Toshiyuki Matsudo ,  Shinpei Nishimura ,  Seiji Tokumoto

IPC: B05C15/00 ,  F24F3/16 ,  F24F3/14 ,  B05C21/00 ,  B05C3/00 ,  B81C99/00 ,  A61M37/00 ,  F24F8/10 ,  B05D3/04

Abstract: The present invention provides a system for manufacturing a therapeutic microneedle configured to regulate an air environment within a coating chamber for manufacturing a therapeutic microneedle by coating a microneedle with a coating liquid containing a drug, the system for manufacturing a therapeutic microneedle comprising an air compressor, a humidity regulator configured to regulate humidity of air supplied from the air compressor, and an air filter configured to eliminate microorganisms from air to be supplied to the inside of the coating chamber.

公开(公告)号：US11077290B2

公开(公告)日：2021-08-03

申请号：US16488450

申请日：2018-02-20

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Toru Kobayashi ,  Toshiyuki Matsudo ,  Shinpei Nishimura ,  Seiji Tokumoto ,  Tetsuji Kuwahara

IPC: A61M37/00

Abstract: A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.

公开(公告)号：US10537723B2

公开(公告)日：2020-01-21

申请号：US15509398

申请日：2015-09-10

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Shinpei Nishimura ,  Seiji Tokumoto

IPC: A61M37/00 ,  A61K9/00 ,  A61K47/18 ,  A61L31/08 ,  A61L31/16

Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; wherein the coating layer comprises a physiologically active substance, arginine, and glycerin.