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公开(公告)号：US11464956B2
公开(公告)日：2022-10-11
申请号：US16488456
申请日：2018-02-20
摘要： A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating layer formed on the microneedles, wherein a length of the microneedles is 300 to 500 μm, the microneedles are disposed on the substrate at a density of 28 to 80 needles/cm2, and the coating layer comprises a biologically active substance. The microneedle device allows the skin irritation caused by administration of an agent to be reduced.
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公开(公告)号：US11141576B2
公开(公告)日：2021-10-12
申请号：US16471290
申请日：2017-12-15
发明人： Takuya Tajima , Naoki Yamamoto , Seiji Tokumoto
IPC分类号： A61M37/00
摘要： An applicator of one embodiment is for applying a sheet member to skin. The applicator includes: a body including a bottom plate configured to face the skin and a bending portion provided to the bottom plate; a cap being movable along a slide direction substantially orthogonal to the bottom plate; and an elastic member configured to extend along the slide direction between the body and the cap. The elastic member applies, to the cap, elastic force that acts in a direction away from the bottom plate, the cap being movable toward the bottom plate against the elastic force. The bending portion bends the sheet member that has advanced thereto in a pressed state in which the cap has been moved toward the bottom plate, thereby applying the sheet member to the skin.
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公开(公告)号：US11116955B2
公开(公告)日：2021-09-14
申请号：US16488450
申请日：2018-02-20
IPC分类号： A61M37/00
摘要： A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.
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公开(公告)号：US10086183B2
公开(公告)日：2018-10-02
申请号：US15032709
申请日：2014-11-04
IPC分类号： A61M37/00
摘要： An applicator is configured to transfer an active ingredient into a body through skin by a puncture in the skin with microneedles. The applicator includes a piston plate that is provided with a first protrusion part and second protrusion parts on a lower surface side of a main body of the piston plate. The microneedles are provided on a surface of the first protrusion part. The second protrusion parts are provided in a periphery of the first protrusion part while spaced apart from the first protrusion part.
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公开(公告)号：US09993549B2
公开(公告)日：2018-06-12
申请号：US15032718
申请日：2014-10-30
发明人： Seiji Tokumoto , Kazuya Machida , Nao Kurokawa , Rie Namiki
CPC分类号： A61K39/39 , A61K9/0014 , A61K9/0021 , A61K9/08 , A61K9/7023 , A61K39/0008 , A61K47/10 , A61K2039/54 , A61K2039/55511
摘要： An adjuvant composition of the present invention contains lauryl alcohol and propylene glycol. Contents of the lauryl alcohol and the propylene glycol are 0.5 to 25% by mass and 8.0 to 99.5% by mass, relative to the total mass of the adjuvant composition, respectively. The lauryl alcohol is dissolved, and the adjuvant composition is used for transdermal or transmucosal administration.
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公开(公告)号：US20150157840A1
公开(公告)日：2015-06-11
申请号：US14407258
申请日：2013-06-11
发明人： Kazuya Kominami , Shinpei Nishimura , Seiji Tokumoto , Makoto Ogura , Toshiyuki Matsudo , Naoki Yamamoto
CPC分类号： A61M37/0015 , A61M37/0092 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61N1/325 , A61N2/002 , A61N2/004
摘要： A microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet substantially along a principal surface of the sheet. The sheet is bent to raise the microneedles from the principal surface, and the raised microneedles pierce a skin.
摘要翻译： 根据一个实施方案的微针片包括形成在基本上沿着片材的主表面的片材上的多个微针。 弯曲片从主表面抬起微针，凸起的微针刺穿皮肤。
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公开(公告)号：US11130148B2
公开(公告)日：2021-09-28
申请号：US14894397
申请日：2014-05-29
IPC分类号： B05C15/00 , F24F3/16 , F24F3/14 , B05C21/00 , B05C3/00 , B81C99/00 , A61M37/00 , F24F8/10 , B05D3/04
摘要： The present invention provides a system for manufacturing a therapeutic microneedle configured to regulate an air environment within a coating chamber for manufacturing a therapeutic microneedle by coating a microneedle with a coating liquid containing a drug, the system for manufacturing a therapeutic microneedle comprising an air compressor, a humidity regulator configured to regulate humidity of air supplied from the air compressor, and an air filter configured to eliminate microorganisms from air to be supplied to the inside of the coating chamber.
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公开(公告)号：US11077290B2
公开(公告)日：2021-08-03
申请号：US16488450
申请日：2018-02-20
IPC分类号： A61M37/00
摘要： A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.
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公开(公告)号：US10537723B2
公开(公告)日：2020-01-21
申请号：US15509398
申请日：2015-09-10
发明人： Shinpei Nishimura , Seiji Tokumoto
摘要： The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; wherein the coating layer comprises a physiologically active substance, arginine, and glycerin.
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公开(公告)号：USD754333S1
公开(公告)日：2016-04-19
申请号：US29470047
申请日：2013-10-17
设计人： Seiji Tokumoto , Makoto Ogura , Kazuya Machida
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