公开(公告)号：US20140161865A1

公开(公告)日：2014-06-12

申请号：US13772843

申请日：2013-02-21

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naruhito Higo ,  Tetsurou Tateishi ,  Takaaki Terahara ,  Kazunosuke Aida ,  Shigeki Hayashi ,  Nobuo Tsutsumi

IPC: A61J3/00 ,  A61K31/216

CPC classification number: A61J3/00 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/216

Abstract: A method for producing a patch having a high skin penetrability and a high pharmaceutical physical properties such as adhesion and cohesiveness, and a long-term storability. The patch is produced by first obtaining an adhesive agent layer composition containing oxybutynin and/or salt thereof as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, an organic acid, and a tackifier; heating the adhesive agent layer composition at a temperature in a range from a melting point of the drug to a temperature higher than the melting point by 10° C. for 2 to 24 hours; and slowly cooling the heated adhesive agent layer composition to obtain the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.

Abstract translation: 一种具有高皮肤渗透性和高的药物物理性质如粘附性和内聚性以及长期保存性的贴剂的制造方法。 通过首先获得含有奥昔布宁和/或其盐作为药物的粘合剂层组合物，作为粘合剂的丙烯酸类聚合物和/或橡胶类聚合物，液体石蜡，有机酸和 增粘剂 在从药物的熔点到高于熔点10℃的温度的温度下加热粘合剂层组合物2〜24小时; 并缓慢冷却加热的粘合剂层组合物以获得以溶解形式的过饱和浓度的包含药物的粘合剂层。

公开(公告)号：US08877235B2

公开(公告)日：2014-11-04

申请号：US13923828

申请日：2013-06-21

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Kazunosuke Aida ,  Terumitsu Kaiho ,  Tetsurou Tateishi ,  Nobuo Tsutsumi

IPC: A61K9/70 ,  A61F13/02 ,  A61K9/00 ,  A61K31/216

CPC classification number: A61K9/0014 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/216

Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising: a step A of obtaining an adhesive agent layer composition comprising oxybutynin hydrochloride as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, a sterol, an organic acid, and a tackifier; a step B of heating the adhesive agent layer composition at a temperature in a range from 55 to 70° C. for 1 to 24 hours; and a step C of cooling the heated adhesive agent layer composition to a temperature lower than room temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.

Abstract translation: 一种贴剂的制造方法，其特征在于，在支撑层的至少一个表面上配置有支撑层和粘合剂层，所述方法包括：获得包含奥昔布宁盐酸盐作为药物的粘合剂层组合物的工序A， 基于聚合物和/或基于橡胶的聚合物作为粘合剂基剂，液体石蜡，固醇，有机酸和增粘剂; 将粘合剂层组合物在55〜70℃的温度范围内加热1〜24小时的工序B; 以及以1〜20℃/小时的平均降温速度将加热的粘合剂层组合物冷却至低于室温的温度的步骤C，从而得到包含过饱和浓度的药物的粘合剂层 一个溶解的形式。

公开(公告)号：US08802134B2

公开(公告)日：2014-08-12

申请号：US13772843

申请日：2013-02-21

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Naruhito Higo ,  Tetsurou Tateishi ,  Takaaki Terahara ,  Kazunosuke Aida ,  Shigeki Hayashi ,  Nobuo Tsutsumi

IPC: A61K9/00 ,  A61F13/02

CPC classification number: A61J3/00 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/216

Abstract: A method for producing a patch having a high skin penetrability and a high pharmaceutical physical properties such as adhesion and cohesiveness, and a long-term storability. The patch is produced by first obtaining an adhesive agent layer composition containing oxybutynin and/or salt thereof as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, an organic acid, and a tackifier; heating the adhesive agent layer composition at a temperature in a range from a melting point of the drug to a temperature higher than the melting point by 10° C. for 2 to 24 hours; and slowly cooling the heated adhesive agent layer composition to obtain the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.

Abstract translation: 一种具有高皮肤渗透性和高的药物物理性质如粘附性和内聚性以及长期保存性的贴剂的制造方法。 通过首先获得含有奥昔布宁和/或其盐作为药物的粘合剂层组合物，作为粘合剂的丙烯酸类聚合物和/或橡胶类聚合物，液体石蜡，有机酸和 增粘剂 在从药物的熔点到高于熔点10℃的温度的温度下加热粘合剂层组合物2〜24小时; 并缓慢冷却加热的粘合剂层组合物以获得以溶解形式的过饱和浓度的包含药物的粘合剂层。