公开(公告)号：US20180149563A1

公开(公告)日：2018-05-31

申请号：US15822780

申请日：2017-11-27

Applicant: Hitachi, Ltd.

Inventor： Yasuaki TAKADA ,  Shun KUMANO ,  Masuyuki SUGIYAMA ,  Hisashi NAGANO ,  Tatsuo NOJIRI ,  Hiroki MIZUNO ,  Yuichiro HASHIMOTO

IPC: G01N1/38 ,  G01N1/40 ,  G01N1/36 ,  G01N33/00

CPC classification number: G01N1/38 ,  G01N1/28 ,  G01N1/36 ,  G01N1/40 ,  G01N33/0011 ,  G01N2001/022 ,  G01N2001/2893 ,  G01N2035/00188

Abstract: An object of the invention is to improve uniformity of a standard sample used for evaluating a gas flow type analysis system. The invention includes weighing a background into a container; adding a sample solution to the background; drying the sample solution; adding a solvent that can dissolve the sample into the container; and drying the solvent added to the container. The invention is also characterized in that the solvent is an organic solvent, in particular, acetone.

公开(公告)号：US20250076306A1

公开(公告)日：2025-03-06

申请号：US18791705

申请日：2024-08-01

Applicant: HITACHI, LTD. ,  ARCALIS, Inc.

Inventor： Shun KUMANO ,  Akihiro NOJIMA ,  Masuyuki SUGIYAMA ,  Rena AKAHORI ,  Shoko KAWAKAMI

IPC: G01N33/68 ,  C12Q1/37 ,  C12Q1/6806 ,  C12Q1/6816 ,  C12Q1/6844

Abstract: There is provided a method for optimizing a nucleic acid sequence, including the steps of: preparing a nucleic acid sequence that includes a candidate sequence containing a sequence of an untranslated region and a sequence encoding a target protein, and a sequence encoding a peptide barcode directly or indirectly linked to the target protein; expressing a protein from the nucleic acid sequence; separating the peptide barcode from the protein; analyzing the separated peptide barcode; and acquiring a relationship between expression of the target protein and the candidate sequence based on a result of the analysis, and selecting an optimal candidate sequence.

公开(公告)号：US20180284083A1

公开(公告)日：2018-10-04

申请号：US15764249

申请日：2015-12-09

Applicant: HITACHI, LTD.

Inventor： Masako ISHIMARU ,  Masao KAMAHORI ,  Masuyuki SUGIYAMA ,  Kazushige NISHIMURA ,  Hiroyuki SATAKE ,  Hideki HASEGAWA

IPC: G01N30/72 ,  G01N30/02

Abstract: In order to implement a high-sensitivity mass spectrometry through an improvement in solvent removal efficiency during electrospray ionization and the like, an ionization device is provided with a light guide path 28 which guides light from a light source to sample microparticles generated by a micronization device to irradiate the microparticles. A closest distance d2 between a spatial area 34 in which the sample microparticles are present and a distal end 29 of the light guide path is greater than or equal to 0.1 mm and less than or equal to 20 mm. A closest distance d1 between an area of light irradiation 35 by the light guide path and any of a sample surface, a micronization device, and a sample holding unit that is the closest is greater than or equal to 0.01 mm and less than or equal to 10 mm.

公开(公告)号：US20200319061A1

公开(公告)日：2020-10-08

申请号：US16305812

申请日：2017-05-29

Applicant: Hitachi, Ltd.

Inventor： Shun KUMANO ,  Masuyuki SUGIYAMA ,  Hisashi NAGANO ,  Makoto NAMAI ,  Takahiro ITOU

IPC: G01N1/22 ,  G01N33/00 ,  G01N21/3504

Abstract: In order to detach substances stably from an inspection object, an adhering substance collecting device includes: ejection openings configured to eject gas; a housing on which the ejection openings are provided; and supporting portions which are installed on a surface of the housing on which the ejection openings are provided, and have a prescribed height. The supporting portions include protruded portions formed on the housing. The supporting portions each have a cuboid shape, and are installed such that a distance therebetween becomes smaller toward a direction of a recovery opening that is configured to collect substances having been detached from an inspection object, from the gas.

公开(公告)号：US20240038524A1

公开(公告)日：2024-02-01

申请号：US18213974

申请日：2023-06-26

Applicant: HITACHI, LTD.

Inventor： Masuyuki SUGIYAMA ,  Shun KUMANO ,  Akihiro NOJIMA

IPC: H01J49/42 ,  H01J49/06 ,  H01J49/00

CPC classification number: H01J49/4225 ,  H01J49/065 ,  H01J49/429 ,  H01J49/0031

Abstract: The present disclosure proposes a mass spectrometer including a linear ion trap section and an analyzer that analyzes the ions ejected from the linear ion trap section having a multipole rod electrode including a plurality of segments arranged in a direction of a center axis of the linear ion trap section. A first radio frequency voltage in opposite phase is applied to adjacent rod electrodes. An electrostatic voltage having the same amplitude and a second radio frequency voltage are applied to the segments having the same position in the direction of the center axis. The electrostatic voltage is applied to the segments such that the electrostatic voltage decreases from an inlet to an outlet of the linear ion trap section. The second radio frequency voltage is applied to the segments such that the second radio frequency voltage increases from the inlet to the outlet of the linear ion trap section.