公开(公告)号：US10431445B2

公开(公告)日：2019-10-01

申请号：US15763813

申请日：2015-10-09

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Kazushige Nishimura ,  Hiroyuki Satake ,  Masuyuki Sugiyama ,  Hideki Hasegawa ,  Tomoyuki Sakai

IPC: H01J49/10 ,  H01J49/16 ,  H01J49/00 ,  H01J49/04 ,  H01J49/06 ,  H01J49/26

Abstract: To reduce contamination of the apparatus with an additive and to quickly switch spraying and stopping of the additive, provided is an ion analyzer including: an ion source for ionizing a measurement target substance, a spray unit for atomizing and spraying toward the measurement target substance a liquid containing an additive that reacts with the measurement target substance; a separation analysis unit for separately analyzing an ion generated by a reaction between the measurement target substance and the additive; a detector for detecting the ion that has been separately analyzed by the separation analysis unit; and a control unit for lowering a flow rate of the additive supplied to the spray unit during a time when the additive is not necessary.

公开(公告)号：US10752941B2

公开(公告)日：2020-08-25

申请号：US15775408

申请日：2015-12-01

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Masataka Shirai ,  Tomoyuki Sakai ,  Kenko Uchida

IPC: C12Q1/68 ,  C12Q1/6837 ,  C12Q1/6806 ,  C12N15/10 ,  C12Q1/6809 ,  C40B40/08 ,  C40B50/06 ,  G01N33/543

Abstract: The purpose of the present invention is to provide a single cell analysis device in which the improvement of the nucleic acid capturing efficiency and the improvement of the cell capturing efficiency are both achieved and a highly accurate single cell analysis data is thereby obtained. The present invention relates to an improvement of a cell analysis device including a two-dimensional array chip having a plurality of cell capture parts capable of capturing a single cell in each of the capture parts, and nucleic acid capture parts corresponding to the respective cell capture parts, the nucleic acid capture parts being capable of capturing a nucleic acid extracted from the cell captured by the cell capture part.