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11 条记录 (耗时 0.01 秒)

    4-(1{40 -Alkyl-5{40 -nitroimidazolyl-2{40 -methylene -imino)-tetrahydro-1,4-thiazine-1,1-dioxides and process for their manufacture
    1.
    发明授权
    4-(1{40 -Alkyl-5{40 -nitroimidazolyl-2{40 -methylene -imino)-tetrahydro-1,4-thiazine-1,1-dioxides and process for their manufacture 失效
    4-（1 {40-烷基-5 {40-硝基咪唑基-2（40-亚甲基 - 亚氨基） - 四氢-1,4-噻嗪-1,1-二氧化物及其制造方法

    公开(公告)号：US3884913A

    公开(公告)日：1975-05-20

    申请号：US42597973

    申请日：1973-12-19

    申请人： HOECHST AG

    发明人： WINKELMANN ERHARDT ,  RAETHER WOLFGANG

    IPC分类号： C07D417/12 ,  C07D295/30 ,  C07D49/36 ,  C09B23/00

    CPC分类号： C07D295/30

    摘要： 4-(1''-ALKYL-5''-NITROIMIDAZOLYL-2''-METHYLENE-IMINO)-TETRAHYDRO1,4-THIAZINE 1,1-DIOXIDES OF THE FORMULA

    IN WHICH R1 is hydrogen, methyl, ethyl, or 2-hydroxy-ethyl and R2 is hydrogen, methyl, ethyl or methoxymethyl, are prepared by reaction of 1-alkyl-5-nitroimidazolyl-2-aldehyde or a functional derivative thereof with 4-amino-tetrahydro-1,4-thiazine 1,1dioxide. The products of the invention are suitable for the treatment of protozoal diseases.

    摘要翻译： 其中R1是氢，甲基，乙基或2-甲氧基的4-（1'-烷基-5'-硝基咪唑烷基-2'-甲基 - 亚氨基） - 四氢-1,4-噻唑锌1,1-二氧化物， 羟基 - 乙基和R2是氢，甲基，乙基或甲氧基甲基，是通过1-烷基-5-硝基咪唑基-2-醛或其官能衍生物与4-氨基 - 四氢-1,4-噻嗪1,1 二氧化物。 本发明的产品适用于治疗原生动物疾病。

    1-(pyridyl-thioalkyl)-2-alkyl-5-nitro-imidazoles
    3.
    发明授权
    1-(pyridyl-thioalkyl)-2-alkyl-5-nitro-imidazoles 失效
    1-（吡啶基 - 硫代甲基）-2-烷基-5-硝基咪唑

    公开(公告)号：US3900482A

    公开(公告)日：1975-08-19

    申请号：US42608173

    申请日：1973-12-19

    申请人： HOECHST AG

    发明人： WINKELMANN ERHARDT ,  RAETHER WOLFGANG

    IPC分类号： C07D401/12 ,  A23K1/16 ,  C07D20060101 ,  C07D31/40

    CPC分类号： C07D401/06

    摘要： 1-(PYRIDYL-THIOALKYL)-2-ALKYL-5-NITRO-IMIDAZOLES OF THE FORMULA

    IN WHICH R1 is hydrogen, methyl or ethyl, -(CH2)n- is an alkyl chain of 2 to 4 carbon atoms which may be branched and to which the pyridyl group is linked in 2-, 3- or 4-position via a sulfur atom, are prepared by reaction of 1-( omega -halogeno-alkyl)-2alkyl-5-nitro-imidazole with mercapto-pyridine in the presence of an acid-binding agent or by reaction of 2-alkyl-5-nitro-imidazole with omega -halogeno-alkyl-thio-pyridine in the presence of an acid-binding agent or with omega -hydroxy-alkyl-thio-pyridine in the presence of a condensation agent or with an aryl-sulfonyloxyalkyl-thio-pyridine. The products of the invention are suitable for the treatment of protozoal diseases.

    Formamidine compounds of diphenyl-sulfone
    4.
    发明授权
    Formamidine compounds of diphenyl-sulfone 失效
    二苯基砜的甲醛化合物

    公开(公告)号：US3621013A

    公开(公告)日：1971-11-16

    申请号：US3621013D

    申请日：1969-03-28

    申请人： HOECHST AG

    发明人： WINKELMANN ERHARDT ,  RAETHER WOLFGANG

    IPC分类号： C07D295/195 ,  C07D87/38

    CPC分类号： C07D295/195

    摘要： Formamidine derivatives of diphenyl-sulfone which are effective medicaments against malaria are prepared by reacting 4,4'' diamino-diphenyl-sulfone of the formula

    WITH N-formyl compounds of the formula

    IN WHICH -N Z is a pyrrolidino, piperidino or morpholino radical, in the presence of acid halides and, if desired, converting the salts thus obtained into the free bases.

    (1-Alkyl-5-nitro-imidazolyl-2-alkyl)-pyridyl compounds
    5.
    发明授权
    (1-Alkyl-5-nitro-imidazolyl-2-alkyl)-pyridyl compounds 失效
    （1-烷基-5-硝基 - 咪唑-2-基） - 吡啶基化合物

    公开(公告)号：US3922277A

    公开(公告)日：1975-11-25

    申请号：US52391774

    申请日：1974-11-14

    申请人： HOECHST AG

    发明人： WINKELMANN ERHARDT ,  RAETHER WOLFGANG

    IPC分类号： C07D401/12

    CPC分类号： C07D401/12

    摘要： (1-Alkyl-5-nitro-imidazolyl-2-alkyl)-pyridyl-sulfides, sulfoxides and -sulfones of the formula I

    in which R1 represents methyl or ethyl, R2 represents a hydrogen atom or methyl, Z represents a sulfide group (-S-), a sulf-oxide group (-SO-) or a sulfone group (-SO2-), which may be linked with the pyridine ring in the 2-, 3- or 4-position, and in which R3 represents a halogen atom, a cyano or nitro group, and process for preparing them. The compounds are active against trichomonas and amebas.

    摘要翻译： （1-烷基-5-硝基 - 咪唑基-2-烷基） - 吡啶基 - 硫化物，式Ⅰ化合物，其中R1代表甲基或乙基，R2代表氢原子或甲基，Z代表硫化物基团 （-S-），亚硫氧烷基（-SO-）或砜基（-SO 2 - ），其可以与2-，3-或4-位的吡啶环连接，并且其中R 3 表示卤素原子，氰基或硝基，以及它们的制备方法。 这些化合物对滴虫和安息日是有效的。

    1-Alkyl-2-(pyridylthiomethyl)-5-nitro-imidazoles and derivatives thereof as well as process for their manufacture
    6.
    发明授权
    1-Alkyl-2-(pyridylthiomethyl)-5-nitro-imidazoles and derivatives thereof as well as process for their manufacture 失效
    1-烷基-2-（吡啶硫基甲基）-5-硝基 - 咪唑及其衍生物及其制备方法

    公开(公告)号：US3907816A

    公开(公告)日：1975-09-23

    申请号：US47066674

    申请日：1974-05-16

    申请人： HOECHST AG

    发明人： WINKELMANN ERHARDT ,  RAETHER WOLFGANG

    IPC分类号： C07D233/93 ,  E05G7/00 ,  C07D213/70

    CPC分类号： C07D233/93

    摘要： This invention provides 1-alkyl-2-(pyridylthiomethyl)-5-nitroimidazoles and 1-alkyl-2-(N-oxy-pyridylthiomethyl)-5-nitroimidazoles of the formula

    in which R is methyl, ethyl or hydroxyethyl and the pyridyl and N-oxy-pyridyl group is linked in 2-, 3- or 4-position to the sulfur atom, as well as process for the manufacture of these compounds. The novel compounds are suitable for the treatment of protozoal diseases in mammals.

    摘要翻译： 本发明提供式-CH 2 -S-（I）O 2 N的1-烷基-2-（吡啶基硫甲基）-5-硝基 - 咪唑和1-烷基-2-（N-氧 - 吡啶基硫甲基）-5-硝基 - 咪唑 其中R是甲基，乙基或羟乙基，吡啶基和N-氧 - 吡啶基在2-，3-或4-位与硫原子连接，以及制备这些化合物的方法。

    1,4-Bis-(5{40 -nitroimidazolyl-2{40 -methylene-imino)-piperazines
    7.
    发明授权
    1,4-Bis-(5{40 -nitroimidazolyl-2{40 -methylene-imino)-piperazines 失效
    1,4-双 - （5（4-硝基咪唑基-2（40-亚甲基 - 亚氨基） - 哌嗪）

    公开(公告)号：US3903081A

    公开(公告)日：1975-09-02

    申请号：US42597373

    申请日：1973-12-19

    申请人： HOECHST AG

    发明人： WINKELMANN ERHARDT ,  RAETHER WOLFGANG

    IPC分类号： C07D233/91 ,  A23K1/16 ,  A61K31/495 ,  C07D295/30 ,  C07D403/14 ,  C07D49/36 ,  C09B55/00

    CPC分类号： C07D295/30 ,  A61K31/495

    摘要： 1,4-BIS-(5''-NITROIMIDAZOLYL-2''-METHYLENE-IMINO) PIPERAZINES OF THE FORMULA

    IN WHICH R1 is hydrogen, methyl, ethyl or 2-hydroxyethyl and R2 is hydrogen or methyl, are prepared by reaction of 5-nitroimidazolyl-2-aldehydes or the functional derivatives thereof with 1,4-diamino-piperazines. The products of the invention are suitable for the treatment of protozoal diseases.

    摘要翻译： 其中R 1为氢，甲基，乙基或2-羟基乙基，R 2为氢或甲基的式（I）化合物的1,4-双 - （5'-硝基咪唑-2-基甲基亚氨基）哌嗪通过5- 硝基 - 咪唑基-2-醛或其功能衍生物与1,4-二氨基 - 哌嗪。 本发明的产品适用于治疗原生动物疾病。

    1-Alkyl-2-(pyridylsulfinylmethyl)-5-nitro-imidazoles and 1-alkyl-2-(pyridylsulfonylmethyl)-5-nitro-imidazoles
    9.
    发明授权
    1-Alkyl-2-(pyridylsulfinylmethyl)-5-nitro-imidazoles and 1-alkyl-2-(pyridylsulfonylmethyl)-5-nitro-imidazoles 失效
    1-烷基-2-（吡啶基亚磺酰基甲基）-5-硝基 - 咪唑和1-烷基-2-（吡啶基磺酰基甲基）-5-硝基 - 咪唑

    公开(公告)号：US3905985A

    公开(公告)日：1975-09-16

    申请号：US47699074

    申请日：1974-06-06

    申请人： HOECHST AG

    发明人： WINKELMANN ERHARDT ,  RAETHER WOLFGANG

    IPC分类号： C07D401/12 ,  A61K31/44 ,  C07D213/70

    CPC分类号： A61K31/44

    摘要： New 1-alkyl-2-(pyridyl-sulfinylmethyl)-5-nitro-imidazoles and 1alkyl-2-(pyridyl-sulfonylmethyl)-5-nitro-imidazoles are described according to the formula I

    in which R stands for a methyl, ethyl or hydroxyethyl group and Z stands for a -SO- or -SO2- group and the pyridine ring is linked to the sulfinyl or the sulfonyl group in 2, 3 or 4 position as well as a process for their manufacture. The novel compounds have a pronounced activity against protozoae, especially trichomonads and amebae.

    摘要翻译： 根据式I描述新的1-烷基-2-（吡啶基 - 亚磺酰基甲基）-5-硝基 - 咪唑和1-烷基-2-（吡啶基 - 磺酰基甲基）-5-硝基 - 咪唑，其中R代表甲基 乙基或羟乙基，Z代表-SO-或-SO2-基团，吡啶环连接于2,3或4位的亚磺酰基或磺酰基，以及其制备方法。