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    Intermediates for preparing acridines
    1.
    发明授权
    Intermediates for preparing acridines 失效
    制备吖啶的中间体

    公开(公告)号：US3919312A

    公开(公告)日：1975-11-11

    申请号：US39548373

    申请日：1973-09-10

    申请人： SMITHKLINE CORP

    发明人： ANDERSON ELVIN L ,  GRABOYES HAROLD

    IPC分类号： C07D219/02 ,  C07C133/02 ,  C07C159/00

    CPC分类号： C07C251/88 ,  C07C251/72 ,  C07D219/02

    摘要： Diphenyl-2-carboxaldehyde derivatives, prepared by reacting a diphenylamine-2-carboxylic acid benzenesulfonylhydrazide with a base and hydrazine, semicarbazide, thiosemicarbazide or phenylhydrazine, are reacted with a mineral acid to produce acridines. The acridines are useful as intermediates for preparing 9-aminoalkylacridans having pharmacodynamic activity.

    摘要翻译： 通过使二苯胺-2-羧酸苯磺酰肼与碱和肼，氨基脲，氨基硫脲或苯肼反应制备的二苯基-2-甲醛衍生物与无机酸反应，生成吖啶。 该吖啶可用作制备具有药效学活性的9-氨基烷基吖啶的中间体。

    Amidophenylisothioureas
    2.
    发明授权
    Amidophenylisothioureas 失效
    AMIDOPHENYLISOTHIOUREAS

    公开(公告)号：US3843715A

    公开(公告)日：1974-10-22

    申请号：US14197871

    申请日：1971-05-10

    申请人： BAYER AG

    发明人： WIDDIG A ,  KUHLE E ,  SCHEINPFLUG H ,  FROHBERGER P ,  GREWE F ,  KASPERS H

    IPC分类号： A01N47/42 ,  A01P3/00 ,  C07C335/38 ,  C07C159/00

    CPC分类号： C07C335/38

    摘要： Amidophenylisothioureas of the formula

    IN WHICH N IS 0, 1 OR 2, EACH X is halogen, lower alkyl or lower alkoxy, R is lower alkyl, R'' is hydrogen or lower alkyl, R'''' is hydrogen; alkyl optionally substituted by at least one of halogen, nitrile, lower alkoxy, lower alkylmercapto, lower alkoxycarbonyl, phenoxy, halogenophenoxy, alkylphenoxy, alkoxyphenoxy and arylmercapto; cycloalkyl; aralkyl optionally substituted by halogen, lower alkyl or lower alkoxy; aryl optionally substituted by halogen, lower alkyl or lower alkoxy; or a five- or six-membered heterocyclic radical containing at least one oxygen, sulfur or nitrogen heteroatom, and R'''''' is alkyl; cycloalkyl; alkenyl; or aralkyl optionally substituted in the aryl moiety by at least one of lower alkyl, lower alkoxy and halogen, WHICH POSSESS FUNGICIDAL PROPERTIES.

    Substituted glyoxal dithiosemicarbazones
    6.
    发明授权
    Substituted glyoxal dithiosemicarbazones 失效
    取代的GLYOXAL DITHIOSEMICARBAZONES

    公开(公告)号：US3709935A

    公开(公告)日：1973-01-09

    申请号：US3709935D

    申请日：1969-03-18

    申请人： BARRETT P

    发明人： BARRETT P

    IPC分类号： A61K31/175 ,  F22B37/44 ,  C07C159/00

    CPC分类号： A61K31/175 ,  F22B37/44 ,  Y10S514/96

    摘要： NOVEL SEMICARBAZONES USEFUL IN THE TREATMENT OF ANAPLASMOSIS HAVING THE FORMULA:

    R1-O-CH(-R2)-C(-CH=N-NH-C(=S)-NH-R4)=N-NH-C(=S)-NH-R3

    WHEREIN R1 IS A METHYL OR ETHYL GROUP, R2 IS A HYDROGEN ATOM OR A METHYL GROUP, AND R3 AND R4 ARE DIFFERENT, EACH BEING A HYDROGEN ATOM, A METHYL OR AN ETHYL GROUP.

    Preparation of lower alkyl thiosemicarbazides
    8.
    发明授权
    Preparation of lower alkyl thiosemicarbazides 失效
    低级烷基氨基硫脲的制备

    公开(公告)号：US4237066A

    公开(公告)日：1980-12-02

    申请号：US955283

    申请日：1978-10-26

    申请人： Danny B. Barton

    发明人： Danny B. Barton

    IPC分类号： C07C20060101 ,  C07C159/00

    CPC分类号： C07C337/06

    摘要： A process for the production of a lower alkyl-thiosemicarbazide comprising steam distilling an aqueous solution containing hydrazine and an N-lower alkyl-dithiocarbamic acid quaternary ammonium salt thereby to effect pyrolysis while distilling off water, lower alkyl amine and hydrogen sulfide, and cooling the distilland to form crystals of the lower alkylthiosemicarbazide. Advantageously the solution is obtained by reacting carbon disulfide and methylamine in water, followed by addition of hydrazine.

    摘要翻译： 一种生产低级烷基 - 氨基硫脲的方法，其中包括蒸馏含有肼的水溶液的蒸汽和N-低级烷基二硫代氨基甲酸季铵盐，从而在蒸馏掉水，低级烷基胺和硫化氢的同时进行热解，并冷却 馏出物形成低级烷基硫代氨基脲的晶体。 有利地，溶液通过二硫化碳和甲胺在水中反应，然后加入肼获得。

    Process for the preparation of 1-tert.-butyl-thiosemicarbazide compounds
    10.
    发明授权
    Process for the preparation of 1-tert.-butyl-thiosemicarbazide compounds 失效
    1-叔丁基 - 氨基硫脲化合物的制备方法

    公开(公告)号：US3907887A

    公开(公告)日：1975-09-23

    申请号：US35669473

    申请日：1973-05-02

    申请人： BAYER AG

    发明人： SASSE KLAUS

    IPC分类号： A01N47/34 ,  C07C20060101 ,  C07C43/00 ,  C07C67/00 ,  C07C325/00 ,  C07C337/06 ,  C07D207/16 ,  C07D211/60 ,  C07D265/30 ,  C07D279/12 ,  C07D521/00 ,  C07C159/00

    CPC分类号： C07C337/06

    摘要： 1-TERT.-BUTYL-THIOSEMICARBAZIDE COMPOUNDS OF THE FORMULA

    wherein R and R'' are hydrogen, aliphatic, cycloaliphatic or aromatic hydrocarbyl (optionally substituted) or where an R and R'' together with the nitrogen linking them can form a heterocyclic system ARE PRODUCED BY REACTING A THIOSEMICARBAZIDE OF THE FORMULA

    with tertiary butanol in the presence of a dehydrating agent at a temperature of from 0* to 100*C.

    摘要翻译： 式（I）R'其中R和R'是氢，脂族，脂环族或芳族烃基（任选取代的）或（其中R 1，R 2，R 3，R 4， 其中R和R'与连接它们的氮原子一起可以形成杂环体系，其通过在脱水剂存在下用叔丁醇反应制备式（II）R'的硫代化合物的硫代化合物 在0℃至100℃的温度下