公开(公告)号：US3448113A

公开(公告)日：1969-06-03

申请号：US3448113D

申请日：1967-07-25

Applicant: HOFFMANN LA ROCHE

Inventor： HOLLANDER CHARLES WILLIAM DEN

IPC: B01J23/40 ,  B01J32/00 ,  C07D213/50 ,  C07D261/20 ,  C07D85/06

CPC classification number: C07D261/20 ,  B01J23/40 ,  B01J32/00 ,  C07D213/50

公开(公告)号：US3448059A

公开(公告)日：1969-06-03

申请号：US3448059D

申请日：1967-07-25

Applicant: HOFFMANN LA ROCHE

Inventor： HOLLANDER CHARLES WILLIAM DEN

IPC: B01J23/40 ,  B01J32/00 ,  C07D213/50 ,  C07D261/20 ,  B01J11/82

CPC classification number: C07D261/20 ,  B01J23/40 ,  B01J32/00 ,  C07D213/50

公开(公告)号：US3682925A

公开(公告)日：1972-08-08

申请号：US3682925D

申请日：1969-01-30

Applicant: HOFFMANN LA ROCHE

Inventor： HOLLANDER CHARLES WILLIAM DEN ,  LEIMGRUBER WILLY ,  MOHACSI ERNEST

IPC: C07D217/24 ,  C07B57/00 ,  C07C67/00 ,  C07C209/00 ,  C07C211/27 ,  C07C213/00 ,  C07C213/10 ,  C07C215/08 ,  C07C215/36 ,  C07C227/34 ,  C07C229/02 ,  C07D217/20 ,  C07D221/28 ,  C07D35/28 ,  C07D43/28

CPC classification number: C07D217/20 ,  C07C215/08 ,  C07D221/28

Abstract: Racemic modifications of optically active amines are treated with (-)-di-O-isopropylidene-2-keto-L-gulonic -keto-L-gulonic acid to form diastereomeric salts. The so-formed diastereomeric salts are separated and chemically decomposed to give the desired enantiomers of the amine. The resolving agent, (-)-di-Oisopropylidene-2-keto-L-gulonic acid, is recovered by precipitation from aqueous solution.

Abstract translation: 用（ - ） - 二-O-异亚丙基-2-酮-L-古洛酮 - 酮-L-古洛糖酸处理光学活性胺的外消旋体改性以形成非对映体盐。 将如此形成的非对映异构体盐分离并化学分解，得到胺的所需对映异构体。 拆分剂（ - ） - 二-O-异亚丙基-2-酮-L-古洛糖酸通过从水溶液中沉淀回收。

公开(公告)号：US3904632A

公开(公告)日：1975-09-09

申请号：US50813074

申请日：1974-09-23

Applicant: HOFFMANN LA ROCHE

Inventor： HOLLANDER CHARLES WILLIAM DEN ,  LEIMGRUBER WILLY ,  MOHACSI ERNEST

IPC: C07H7/027 ,  C07D221/28 ,  C07D407/04

CPC classification number: C07H7/027

Abstract: Racemic modifications of optically active amines are treated with (-)-di-O-isopropylidene-2-keto-L-gulonic acid to form diastereomeric salts. The so-formed diastereomeric salts are separated and chemically decomposed to give the desired enantiomers of the amine. The resolving agent, (-)-di-Oisopropylidene-2-keto-L-gulonic acid, is recovered by precipitation from aqueous solution.

公开(公告)号：US3590044A

公开(公告)日：1971-06-29

申请号：US3590044D

申请日：1966-08-19

Applicant: HOFFMANN LA ROCHE

Inventor： HOLLANDER CHARLES WILLIAM DEN

IPC: C07D217/08 ,  C07D217/06 ,  C07D491/056 ,  C07D33/50

CPC classification number: C07D217/06

Abstract: 1,2,3,4-TETRAHYDRO-ISOQUINOLIN-2-CARBOXAMIDINES OF THE FORMULA

2-(NH2-C(=NH)-),6-R1,7-R2-1,2,3,4-TETRAHYDROISOQUINOLINE

WHEREIN R1 AND R2, INDIVIDUALLY, ARE HYDROGEN, HYDROXYL AND LOWER ALKOXY, AND TOGETHER, ARE ALKYLENEDIOXY, ARE PREPARED FROM THE CORRESPONDING 1,2,3,4-TETRAHYDROISOQUINOLINE BY TREATMENT WITH CYANAMIDE IN AN AQUEOUS ALCOHOLIC MEDIUM AT A CONTROLLED PH. THE END PRODUCTS ARE USEFUL AS HYPOTENSIVE AGENTS.

公开(公告)号：US3536729A

公开(公告)日：1970-10-27

申请号：US3536729D

申请日：1967-06-30

Applicant: HOFFMANN LA ROCHE

Inventor： HOLLANDER CHARLES WILLIAM DEN

IPC: C07D261/14 ,  C07D261/16 ,  C07D85/22

CPC classification number: C07D261/16 ,  C07D261/14