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22 条记录 (耗时 0.022 秒)

    Process for the preparation of 2-phenyl-[1,2,4]triazolo[1,5-a]pyridine derivatives
    1.
    发明授权
    Process for the preparation of 2-phenyl-[1,2,4]triazolo[1,5-a]pyridine derivatives 有权
    制备2-苯基 - [1,2,4]三唑并[1,5-a]吡啶衍生物的方法

    公开(公告)号：US09115130B2

    公开(公告)日：2015-08-25

    申请号：US14455773

    申请日：2014-08-08

    申请人： Hoffmann-La Roche Inc.

    发明人： Bjoern Bartels ,  Serena Maria Fantasia ,  Alexander Flohr ,  Kurt Puentener ,  Shaoning Wang

    IPC分类号： C07D498/02 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： The invention relates to a novel process for the preparation of 2-phenyl-[1,2,4]triazolo[1,5-a]pyridine derivatives of formula I or of a salt thereof wherein R1 stands for hydrogen, a halogen, for an optionally protected hydroxyl group or for an optionally protected amino group and R2 is hydrogen or a halogen. 2-Phenyl-[1,2,4]triazolo[1,5-a]pyridine derivatives of formula I with their 1,2,4-triazole nucleus build the structural core of a great number of functionalized molecules in medicinal chemistry.

    摘要翻译： 本发明涉及制备式I的2-苯基 - [1,2,4]三唑并[1,5-a]吡啶衍生物或其盐的新方法，其中R1代表氢，卤素，用于 任选保护的羟基或任选保护的氨基，R 2是氢或卤素。 式Ⅰ的2-苯基 - [1,2,4]三唑并[1,5-a]吡啶衍生物与其1,2,4-三唑核构成药物化学中大量官能化分子的结构核心。

    TRIAZOLOPYRIDINE COMPOUNDS
    3.
    发明申请
    TRIAZOLOPYRIDINE COMPOUNDS 有权
    三唑啉化合物

    公开(公告)号：US20140303141A1

    公开(公告)日：2014-10-09

    申请号：US14218275

    申请日：2014-03-18

    申请人： Hoffmann-La Roche Inc.

    发明人： Alexander Flohr ,  Katrin Groebke Zbinden ,  Matthias Koerner

    IPC分类号： C07D471/04

    CPC分类号： C07D471/04

    摘要： The invention is concerned with triazolopyridine compounds of formula (I) wherein R1, R2 and R3 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.

    摘要翻译： 本发明涉及式（I）的三唑并吡啶化合物，其中R 1，R 2和R 3如说明书和权利要求书中所定义，以及其生理上可接受的盐。 这些化合物抑制PDE10A，可用作药物。

    Dimeric compounds
    4.
    发明授权
    Dimeric compounds 有权

    公开(公告)号：US10398702B2

    公开(公告)日：2019-09-03

    申请号：US16095262

    申请日：2017-05-05

    申请人： Hoffmann-La Roche Inc.

    发明人： Alexander Flohr ,  Guido Galley ,  Roger Norcross ,  Nicolas Zorn

    IPC分类号： A61K31/5355 ,  C07D413/14 ,  A61P35/00 ,  C07K16/18

    摘要： The present invention provides a compound of formula I which act as inhibitors of SMAC protein binding to Inhibitor of Apoptosis Proteins (IAPs), and/or inhibitors of activated caspase protein binding to IAPs (I) their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances, alone or in combination with DR5/FAP agonist antibodies. The active compound of the present invention is useful in the amelioration, treatment or control of cancer, especially solid tumors.

    IMIDAZOLE DERIVATIVES
    5.
    发明申请
    IMIDAZOLE DERIVATIVES 有权
    咪唑衍生物

    公开(公告)号：US20160264585A1

    公开(公告)日：2016-09-15

    申请号：US15162919

    申请日：2016-05-24

    申请人： Hoffmann-La Roche Inc.

    发明人： Alexander Flohr

    IPC分类号： C07D487/04 ,  C07D403/14

    CPC分类号： C07D487/04 ,  C07D403/14

    摘要： The present invention relates to compounds of formula (I), wherein A, B, R1 and R2 are as defined herein before useful for the treatment of psychiatric disorders.

    摘要翻译： 在此之前定义可用于治疗精神疾病。