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公开(公告)号：US10562905B2
公开(公告)日：2020-02-18
申请号：US16247084
申请日：2019-01-14
发明人： Taishan Hu , Buyu Kou , Haixia Liu , Zhisen Zhang , Zheng Zhou
IPC分类号： C07D487/04 , C07D487/08 , C07D498/08 , A61P31/20
摘要： The present invention relates to compounds of the formula (I), or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R3 are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.
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2.发明申请公开(公告)号：US20190248792A1
公开(公告)日：2019-08-15
申请号：US16247170
申请日：2019-01-14
发明人： Xingchun Han , Xianfeng Lin , Hong Shen , Taishan Hu , Zhisen Zhang
IPC分类号： C07D487/04 , A61P31/20 , C07D519/00
摘要： The present invention relates to compounds of the formula (I), or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R4 and Q are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.
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公开(公告)号：US20180334461A1
公开(公告)日：2018-11-22
申请号：US15846910
申请日：2017-12-19
发明人： Taishan Hu , Xingchun Han , Buyu Kou , Hong Shen , Shixiang Yan , Zhisen Zhang
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to compounds of the formula (I), or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R4 are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.
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4.发明授权6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection 有权6-氨基酸杂芳基二氢嘧啶用于治疗和预防乙型肝炎病毒感染公开(公告)号：US09447086B2
公开(公告)日：2016-09-20
申请号：US14022519
申请日：2013-09-10
发明人： Lei Guo , Taishan Hu , Yimin Hu , Buelent Kocer , Xianfeng Lin , Haixia Liu , Alexander V Mayweg , Zongxing Qiu , Hong Shen , Guozhi Tang , Lisha Wang , Guolong Wu , Shixiang Yan , Weixing Zhang , Mingwei Zhou , Wei Zhu
IPC分类号： C07D401/14 , A61K31/506 , C07D417/14 , A61K31/5377 , A61K31/541
CPC分类号： C07D417/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D403/06 , C07D409/14 , C07D413/14 , A61K2300/00
摘要： The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4 and A are as described herein, compositions including the compounds and methods of using the compounds.
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5.发明申请NOVEL 6-BRIDGED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION 审中-公开用于治疗和预防乙型肝炎病毒感染的新型6-桥联异噻唑啉酮公开(公告)号：US20160122363A1
公开(公告)日：2016-05-05
申请号：US14991786
申请日：2016-01-08
发明人： Lei Guo , Taishan Hu , Yimin Hu , Buelent Kocer , Buyu Kou , Gangqin Li , Xianfeng Lin , Haixia Liu , Hong Shen , Houguang Shi , Guolong Wu , Zhisen Zhang , Mingwei Zhou , Wei Zhu
IPC分类号： C07D498/18 , C07D471/08 , C07D491/08 , C07D513/08 , C07D498/08 , C07D417/14
CPC分类号： C07D498/18 , A61K31/506 , C07D417/14 , C07D453/06 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D498/08 , C07D498/20 , C07D513/08
摘要： The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有以下通式的新化合物：其中R 1，R 2，R 3和R 4如说明书和权利要求书中所定义，以及其药学上可接受的盐或互变异构体异构体或其对映异构体或非对映异构体。 本发明还包含包含化合物的组合物和使用该化合物的方法。
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6.发明授权6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection 有权6-稠合的杂芳基二氢嘧啶用于治疗和预防乙型肝炎病毒感染公开(公告)号：US09233978B2
公开(公告)日：2016-01-12
申请号：US14640397
申请日：2015-03-06
发明人： Lei Guo , Taishan Hu , Buyu Kou , Xianfeng Lin , Hong Shen , Houguang Shi , Shixiang Yan , Weixing Zhang , Zhisen Zhang , Mingwei Zhou , Wei Zhu
IPC分类号： A61K31/519 , C07D498/04 , C07D487/04 , C07D471/04 , C07D513/04 , A61K31/517
CPC分类号： C07D471/04 , A61K31/4985 , A61K31/517 , A61K31/519 , C07D487/04 , C07D498/04 , C07D513/04
摘要： The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有以下通式的新化合物：其中R1，R2，R3，R4，R5，R6，X，Y，W和n如本文所述，包括该化合物的组合物和使用该化合物的方法。
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公开(公告)号：US20220411468A1
公开(公告)日：2022-12-29
申请号：US17377338
申请日：2021-07-15
发明人： Alexander Alanine , Julien Beignet , Konrad Bleicher , Bernhard Fasching , Hans Hilpert , Taishan Hu , Dwight MacDonald , Stephen Jackson , Sabine Kolczewski , Carsten Kroll , Adrian Schaeublin , Hong Shen , Theodor Stoll , Helmut Thomas , Amal Wahhab , Claudia Zampaloni
摘要： The present invention provides compounds of formula (I) wherein X1 to X8 and R1 to R8 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by Acinetobacter baumannii.
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8.发明申请公开(公告)号：US20200062753A1
公开(公告)日：2020-02-27
申请号：US16531624
申请日：2019-08-05
发明人： Lei Guo , Taishan Hu , Buyu Kou , Xianfeng Lin , Hong Shen , Houguang Shi , Shixiang Yan , Weixing Zhang , Zhisen Zhang , Mingwei Zhou , Wei Zhu
IPC分类号： C07D471/04 , A61K31/4985 , C07D487/04 , C07D513/04 , C07D498/04
摘要： The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.
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9.发明申请公开(公告)号：US20190322670A1
公开(公告)日：2019-10-24
申请号：US16247084
申请日：2019-01-14
发明人： Taishan Hu , Buyu Kou , Haixia Liu , Zhisen Zhang , Zheng Zhou
IPC分类号： C07D487/04 , A61P31/20 , C07D498/08
摘要： The present invention relates to compounds of the formula (I), or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R3 are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.
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10.发明授权公开(公告)号：US10428069B2
公开(公告)日：2019-10-01
申请号：US16103198
申请日：2018-08-14
发明人： Lei Guo , Taishan Hu , Buyu Kou , Xianfeng Lin , Hong Shen , Houguang Shi , Shixiang Yan , Weixing Zhang , Zhisen Zhang , Mingwei Zhou , Wei Zhu
IPC分类号： C07D471/04 , A61K31/4985 , C07D487/04 , C07D498/04 , C07D513/04 , A61K31/517 , A61K31/519
摘要： The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.
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