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公开(公告)号：US09758530B2
公开(公告)日：2017-09-12
申请号：US14991786
申请日：2016-01-08
发明人： Lei Guo , Taishan Hu , Yimin Hu , Buelent Kocer , Buyu Kou , Gangqin Li , Xianfeng Lin , Haixia Liu , Hong Shen , Houguang Shi , Guolong Wu , Zhisen Zhang , Mingwei Zhou , Wei Zhu
IPC分类号： A61K31/506 , C07D498/18 , C07D498/08 , C07D491/18 , C07D453/06 , C07D471/08 , C07D513/08 , C07D417/14 , C07D487/08 , C07D491/08 , C07D498/20
CPC分类号： C07D498/18 , A61K31/506 , C07D417/14 , C07D453/06 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D498/08 , C07D498/20 , C07D513/08
摘要： The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.
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![2-oxa-5-azabicyclo[2.2.1]heptan-3-yl derivatives](/abs-image/US/2017/10/17/US09790230B2/abs.jpg.150x150.jpg)
公开(公告)号：US09790230B2
公开(公告)日：2017-10-17
申请号：US15416485
申请日：2017-01-26
发明人： Giuseppe Cecere , Guido Galley , Yimin Hu , Roger Norcross , Philippe Pflieger , Hong Shen
IPC分类号： C07D491/08
CPC分类号： C07D491/08 , C07D491/06
摘要： The present invention relates to compounds of formula of formula I wherein X, L and R1 are as described herein, compositions containing compounds of formula I, methods of manufacture of compounds of formula I and methods of treating psychiatric, metabolic, cardiovascular or sleep disorders with compounds of formula I.
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3.发明授权6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection 有权6-氨基酸杂芳基二氢嘧啶用于治疗和预防乙型肝炎病毒感染公开(公告)号：US09447086B2
公开(公告)日：2016-09-20
申请号：US14022519
申请日：2013-09-10
发明人： Lei Guo , Taishan Hu , Yimin Hu , Buelent Kocer , Xianfeng Lin , Haixia Liu , Alexander V Mayweg , Zongxing Qiu , Hong Shen , Guozhi Tang , Lisha Wang , Guolong Wu , Shixiang Yan , Weixing Zhang , Mingwei Zhou , Wei Zhu
IPC分类号： C07D401/14 , A61K31/506 , C07D417/14 , A61K31/5377 , A61K31/541
CPC分类号： C07D417/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D403/06 , C07D409/14 , C07D413/14 , A61K2300/00
摘要： The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4 and A are as described herein, compositions including the compounds and methods of using the compounds.
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4.发明申请NOVEL 6-BRIDGED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION 审中-公开用于治疗和预防乙型肝炎病毒感染的新型6-桥联异噻唑啉酮公开(公告)号：US20160122363A1
公开(公告)日：2016-05-05
申请号：US14991786
申请日：2016-01-08
发明人： Lei Guo , Taishan Hu , Yimin Hu , Buelent Kocer , Buyu Kou , Gangqin Li , Xianfeng Lin , Haixia Liu , Hong Shen , Houguang Shi , Guolong Wu , Zhisen Zhang , Mingwei Zhou , Wei Zhu
IPC分类号： C07D498/18 , C07D471/08 , C07D491/08 , C07D513/08 , C07D498/08 , C07D417/14
CPC分类号： C07D498/18 , A61K31/506 , C07D417/14 , C07D453/06 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D498/08 , C07D498/20 , C07D513/08
摘要： The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有以下通式的新化合物：其中R 1，R 2，R 3和R 4如说明书和权利要求书中所定义，以及其药学上可接受的盐或互变异构体异构体或其对映异构体或非对映异构体。 本发明还包含包含化合物的组合物和使用该化合物的方法。
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![Novel pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection](/abs-image/US/2020/10/29/US20200339603A1/abs.jpg.150x150.jpg)
5.发明申请公开(公告)号：US20200339603A1
公开(公告)日：2020-10-29
申请号：US16862442
申请日：2020-04-29
发明人： Yimin Hu , Chengang Zhou , Mingwei Zhou , Houguang Shi , Yongqiang Liu , Hong Shen , Maarten Vercruysse , Shixiang Yan , Xuefei Tan , Xianfeng Lin , Fabian Dey
IPC分类号： C07D519/00 , C07D471/04 , A61P31/04
摘要： The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
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![5-OXA-2-AZABICYCLO[2.2.2]OCTAN-4-YL AND 5-OXA-2-AZABICYCLO[2.2.1]HEPTAN-4-YL DERIVATIVES](/abs-image/US/2017/03/09/US20170066775A1/abs.jpg.150x150.jpg)
6.发明申请5-OXA-2-AZABICYCLO[2.2.2]OCTAN-4-YL AND 5-OXA-2-AZABICYCLO[2.2.1]HEPTAN-4-YL DERIVATIVES 有权5-OXA-2-氮杂双环[2.2.2]十四烷-4-基和5-氧代-2-氮杂双环[2.2.1] HEPTAN-4-YL衍生物公开(公告)号：US20170066775A1
公开(公告)日：2017-03-09
申请号：US15356974
申请日：2016-11-21
发明人： Giuseppe Cecere , Guido Galley , Yimin Hu , Roger Norcross , Philippe Pflieger , Hong Shen
IPC分类号： C07D491/08
CPC分类号： C07D491/08
摘要： The present invention relates to compounds of formula of formula I wherein X, Ar, R1, m and n are as described herein, compositions containing compounds of formula I, methods of manufacture of compounds of formula I and methods of treating psychiatric disorders with compounds of formula I.
摘要翻译： 本发明涉及式（I）的化合物，其中..... C .....是-CH 2 - 或-CH 2 -CH 2 - ; X是-NH-，-C（O）NH-或-NHC（O）NH-; Ar是苯基或含有一个或两个N原子的5或6元杂芳基; R1是卤素，低级烷基，被卤素取代的低级烷基，低级烷氧基，被环烷基取代的低级烷氧基，被卤素取代的低级烷氧基或是环烷基; - （） - 是-CH 2 - ; n为0或1; m为0,1或2; 或其药学上合适的酸加成盐，适用于所有外消旋混合物，其所有相应的对映体和/或光学异构体，该化合物可用于治疗抑郁症，焦虑障碍，双相情感障碍，注意力缺陷多动障碍（ADHD） 压力相关疾病，精神障碍，精神分裂症，神经系统疾病，帕金森病，神经变性疾病，阿尔茨海默病，癫痫，偏头痛，高血压，物质滥用，代谢紊乱，进食障碍，糖尿病，糖尿病并发症，肥胖，血脂异常，能量消耗障碍 和体温平衡的同化，紊乱和功能障碍，睡眠和昼夜节律紊乱以及心血管疾病。
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7.发明申请Novel 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection 有权新型6-氨基酸杂芳基二氢嘧啶用于治疗和预防乙型肝炎病毒感染公开(公告)号：US20150031687A1
公开(公告)日：2015-01-29
申请号：US14022519
申请日：2013-09-10
发明人： Lei Guo , Taishan Hu , Yimin Hu , Buelent Kocer , Xianfeng Lin , Haixia Liu , Alexander V Mayweg , Zongxing Qiu , Hong Shen , Guozhi Tang , Lisha Wang , Guolong Wu , Shixiang Yan , Weixing Zhang , Mingwei Zhou , Wei Zhu
IPC分类号： C07D417/14 , A61K31/5377 , A61K31/541 , A61K31/506
CPC分类号： C07D417/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D403/06 , C07D409/14 , C07D413/14 , A61K2300/00
摘要： The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4 and A are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有以下通式的新化合物：其中R 1，R 2，R 3，R 4和A如本文所述，包括该化合物的组合物和使用该化合物的方法。
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8.发明申请NOVEL 6-BRIDGED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION 有权用于治疗和预防乙型肝炎病毒感染的新型6-桥联异噻唑啉酮公开(公告)号：US20140343032A1
公开(公告)日：2014-11-20
申请号：US14279716
申请日：2014-05-16
发明人： Lei Guo , Taishan Hu , Yimin Hu , Buelent Kocer , Buyu Kou , Gangqin Li , Xianfeng Lin , Haixia Liu , Hong Shen , Houguang Shi , Guolong Wu , Zhisen Zhang , Mingwei Zhou , Wei Zhu
IPC分类号： C07D498/08 , C07D498/18 , C07D498/20 , C07D487/08 , C07D513/08 , C07D417/14 , C07D491/08
CPC分类号： C07D498/18 , A61K31/506 , C07D417/14 , C07D453/06 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D498/08 , C07D498/20 , C07D513/08
摘要： The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有以下通式的新化合物：其中R 1，R 2，R 3和R 4如说明书和权利要求书中所定义，以及其药学上可接受的盐或互变异构体异构体或其对映异构体或非对映异构体。 本发明还包含包含化合物的组合物和使用该化合物的方法。
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![Novel pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection](/abs-image/US/2018/11/15/US20180327425A1/abs.jpg.150x150.jpg)
9.发明申请公开(公告)号：US20180327425A1
公开(公告)日：2018-11-15
申请号：US15941313
申请日：2018-03-30
发明人： Yimin Hu , Chengang Zhou , Mingwei Zhou , Houguang Shi , Yongqiang Liu , Hong Shen , Maarten Vercruysse , Shixiang Yan , Xuefei Tan , Xianfeng Lin , Fabian Dey
IPC分类号： C07D519/00 , A61P31/04
摘要： The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
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![5-oxa-2-azabicyclo[2.2.2]OCTAN-4-yl and 5-oxa-2-azabicyclo[2.2.1]heptan-4-yl derivatives](/abs-image/US/2017/05/30/US09663530B2/abs.jpg.150x150.jpg)
10.发明授权公开(公告)号：US09663530B2
公开(公告)日：2017-05-30
申请号：US15356974
申请日：2016-11-21
发明人： Giuseppe Cecere , Guido Galley , Yimin Hu , Roger Norcross , Philippe Pflieger , Hong Shen
IPC分类号： C07D491/08 , A61K31/537
CPC分类号： C07D491/08
摘要： The present invention relates to compounds of formula of formula I wherein X, Ar, R1, m and n are as described herein, compositions containing compounds of formula I, methods of manufacture of compounds of formula I and methods of treating psychiatric disorders with compounds of formula I.
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