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    Isolated protein comprising an activin type IIB5 receptor polypeptide and uses thereof
    1.
    发明授权
    Isolated protein comprising an activin type IIB5 receptor polypeptide and uses thereof 有权
    包含激活素IIB5型受体多肽的分离蛋白及其用途

    公开(公告)号：US08614292B2

    公开(公告)日：2013-12-24

    申请号：US13190255

    申请日：2011-07-25

    申请人： HQ Han ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    发明人： HQ Han ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC分类号： A61K38/00 ,  A61K38/18 ,  A61P3/04 ,  C07K14/51

    CPC分类号： C07K14/71 ,  C07K2319/30

    摘要： The present invention provides novel activin IIB5 receptor polypeptides capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the receptor polypeptides. Compositions and methods for treating muscle-wasting, metabolic and other disorders are also provided.

    摘要翻译： 本发明提供能够结合并抑制活化素A，肌生成抑制素或GDF-11的活性的新型激活素IIB5受体多肽。 本发明还提供能够产生受体多肽的多核苷酸，载体和宿主细胞。 还提供了用于治疗肌肉消瘦，代谢和其它疾病的组合物和方法。

    Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1
    2.
    发明授权
    Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1 有权
    分离的核酸分子，其包含SEQ ID NO：1的氨基酸序列

    公开(公告)号：US08067562B2

    公开(公告)日：2011-11-29

    申请号：US11590962

    申请日：2006-10-31

    申请人： HQ Han ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    发明人： HQ Han ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N15/00 ,  C12N5/02

    CPC分类号： C07K14/71 ,  C07K2319/30

    摘要： The present invention provides novel activin IIB5 receptor polypeptides capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the receptor polypeptides. Compositions and methods for treating muscle-wasting, metabolic and other disorders are also provided.

    摘要翻译： 本发明提供能够结合并抑制活化素A，肌生成抑制素或GDF-11的活性的新型激活素IIB5受体多肽。 本发明还提供能够产生受体多肽的多核苷酸，载体和宿主细胞。 还提供了用于治疗肌肉消瘦，代谢和其它疾病的组合物和方法。

    Anti-activin a antibodies and uses thereof
    5.
    发明授权
    Anti-activin a antibodies and uses thereof 有权
    抗激活素抗体及其用途

    公开(公告)号：US08753627B2

    公开(公告)日：2014-06-17

    申请号：US13550447

    申请日：2012-07-16

    申请人： Hui-Quan Han ,  Qing Chen ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    发明人： Hui-Quan Han ,  Qing Chen ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC分类号： A61K39/395 ,  A61K39/00 ,  G01N33/53 ,  C07K16/00 ,  C07K16/24 ,  C07H21/04 ,  C12N15/00

    CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

    摘要： The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

    摘要翻译： 本公开提供与抗激活素A结合蛋白（包括抗体）相关或衍生的组合物和方法。 在具体实施方案中，本公开提供了完整的人，人源化和嵌合的抗激活蛋白A抗体，其结合人激活素A，激活素A结合片段和此类抗体的衍生物，以及包含此类片段的激活素A-结合多肽。 其他实施方案提供编码此类抗体，抗体片段和衍生物和多肽的核酸，包含此类多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用此类抗体，抗体片段和衍生物和多肽的方法，包括方法 治疗或诊断具有激素A相关疾病或包括与性腺癌，其他癌症，类风湿性关节炎和其它疾病相关的恶病质的病症的受试者。

    ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF
    7.
    发明申请
    ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF 有权

    公开(公告)号：US20130030159A1

    公开(公告)日：2013-01-31

    申请号：US13550447

    申请日：2012-07-16

    申请人： Hui-Quan Han ,  Qing Chen ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    发明人： Hui-Quan Han ,  Qing Chen ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC分类号： C07K16/26

    CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

    摘要： The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

    Anti-activin A antibodies and uses thereof
    9.
    发明授权
    Anti-activin A antibodies and uses thereof 有权
    抗激活素A抗体及其用途

    公开(公告)号：US08309082B2

    公开(公告)日：2012-11-13

    申请号：US11851884

    申请日：2007-09-07

    申请人： Hui-Quan Han ,  Qing Chen ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    发明人： Hui-Quan Han ,  Qing Chen ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

    IPC分类号： G01N33/53 ,  A61K39/395 ,  C07K16/00 ,  C07K16/28

    CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

    摘要： The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

    摘要翻译： 本公开提供与抗激活素A结合蛋白（包括抗体）相关或衍生的组合物和方法。 在具体实施方案中，本公开提供了完整的人，人源化和嵌合的抗激活蛋白A抗体，其结合人激活素A，激活素A结合片段和此类抗体的衍生物，以及包含此类片段的激活素A-结合多肽。 其他实施方案提供编码此类抗体，抗体片段和衍生物和多肽的核酸，包含此类多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用此类抗体，抗体片段和衍生物和多肽的方法，包括方法 治疗或诊断具有激素A相关疾病或包括与性腺癌，其他癌症，类风湿性关节炎和其它疾病相关的恶病质的病症的受试者。