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公开(公告)号:USD952795S1
公开(公告)日:2022-05-24
申请号:US29767716
申请日:2021-01-25
申请人: Haibin Wang
设计人: Haibin Wang
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公开(公告)号:US08906947B2
公开(公告)日:2014-12-09
申请号:US12865581
申请日:2008-02-01
申请人: Jidong Wang , Hui Zhang , Haibin Wang , Lingping Ying , Sheng Wang , Xufang Guan , Hua Bai
发明人: Jidong Wang , Hui Zhang , Haibin Wang , Lingping Ying , Sheng Wang , Xufang Guan , Hua Bai
IPC分类号: C07D493/04 , C07D417/06 , A61K31/427 , A61P35/00
CPC分类号: C07D417/06 , C07D493/04
摘要: The invention discloses a method for the separation and purification of epothilones, especially discloses a method for the separation and purification of epothilones B and A using normal phase silica gel chromatography, which comprises loading the sample after dissolving the sample containing epothilones B and A with C1-C7 alkyl halide compounds or mixing the sample with silica gel, then gradient eluting silica gel column by an elution solvent of normal phase silica gel column, and finally obtaining products.
摘要翻译: 本发明公开了一种分离和纯化埃坡霉素的方法,特别公开了一种使用正相硅胶色谱分离和纯化埃坡霉素B和A的方法,该方法包括在将含有埃坡霉素B和A的样品溶解于C1后加载样品 -C7烷基卤化物,或将样品与硅胶混合,然后用正相硅胶柱洗脱溶剂梯度洗脱硅胶柱,最后得到产物。
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公开(公告)号:US08445662B2
公开(公告)日:2013-05-21
申请号:US13446098
申请日:2012-04-13
申请人: Xiuyun He , Yuhui Zhuang , Haibin Wang , Jianhua Tao
发明人: Xiuyun He , Yuhui Zhuang , Haibin Wang , Jianhua Tao
CPC分类号: C07K14/35 , A61K39/00 , A61K39/04 , A61K2039/55594 , C07K2319/40
摘要: The present invention is related to a M. tuberculosis fusion protein, polynucleotide coding for said protein, and a vector and host cell that contain said polynucleotide. The present invention also involves the preparation of said fusion protein, and the use thereof in preventions and treatment of tuberculosis.
摘要翻译: 本发明涉及结核分枝杆菌融合蛋白,编码所述蛋白质的多核苷酸以及含有所述多核苷酸的载体和宿主细胞。 本发明还涉及所述融合蛋白的制备及其在预防和治疗结核病中的应用。
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公开(公告)号:US08173773B2
公开(公告)日:2012-05-08
申请号:US12160280
申请日:2007-01-10
申请人: Xiuyun He , Yuhui Zhuang , Haibin Wang , Jianhua Tao
发明人: Xiuyun He , Yuhui Zhuang , Haibin Wang , Jianhua Tao
IPC分类号: C07K1/00
CPC分类号: C07K14/35 , A61K39/00 , A61K39/04 , A61K2039/55594 , C07K2319/40
摘要: The present invention is related to a M. tuberculosis fusion protein, polynucleotide coding for said protein, and a vector and host cell that contain said polynucleotide. The present invention also involves the preparation of said fusion protein, and the use thereof in preventions and treatment of tuberculosis.
摘要翻译: 本发明涉及结核分枝杆菌融合蛋白,编码所述蛋白质的多核苷酸以及含有所述多核苷酸的载体和宿主细胞。 本发明还涉及所述融合蛋白的制备及其在预防和治疗结核病中的应用。
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公开(公告)号:US20100311796A1
公开(公告)日:2010-12-09
申请号:US12865581
申请日:2008-02-01
申请人: Jidong Wang , Hui Zhang , Haibin Wang , Lingping Ying , Sheng Wang , Xufang Guan , Hua Bai
发明人: Jidong Wang , Hui Zhang , Haibin Wang , Lingping Ying , Sheng Wang , Xufang Guan , Hua Bai
IPC分类号: A61K31/427 , A61P35/00
CPC分类号: C07D417/06 , C07D493/04
摘要: The invention discloses a method for the separation and purification of epothilones, especially discloses a method for the separation and purification of epothilones B and A using normal phase silica gel chromatography, which comprises loading the sample after dissolving the sample containing epothilones B and A with C1-C7 alkyl halide compounds or mixing the sample with silica gel, then gradient eluting silica gel column by an elution solvent of normal phase silica gel column, and finally obtaining products.
摘要翻译: 本发明公开了一种分离和纯化埃坡霉素的方法,特别公开了一种使用正相硅胶色谱分离和纯化埃坡霉素B和A的方法,该方法包括在将含有埃坡霉素B和A的样品溶解于C1后加载样品 -C7烷基卤化物,或将样品与硅胶混合,然后用正相硅胶柱洗脱溶剂梯度洗脱硅胶柱,最后得到产物。
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