METHOD FOR THE SEPARATION AND PURIFICATION OF EPOTHILONES
    5.
    发明申请
    METHOD FOR THE SEPARATION AND PURIFICATION OF EPOTHILONES 有权
    分离和纯化EPOTHILON的方法

    公开(公告)号:US20100311796A1

    公开(公告)日:2010-12-09

    申请号:US12865581

    申请日:2008-02-01

    IPC分类号: A61K31/427 A61P35/00

    CPC分类号: C07D417/06 C07D493/04

    摘要: The invention discloses a method for the separation and purification of epothilones, especially discloses a method for the separation and purification of epothilones B and A using normal phase silica gel chromatography, which comprises loading the sample after dissolving the sample containing epothilones B and A with C1-C7 alkyl halide compounds or mixing the sample with silica gel, then gradient eluting silica gel column by an elution solvent of normal phase silica gel column, and finally obtaining products.

    摘要翻译: 本发明公开了一种分离和纯化埃坡霉素的方法,特别公开了一种使用正相硅胶色谱分离和纯化埃坡霉素B和A的方法,该方法包括在将含有埃坡霉素B和A的样品溶解于C1后加载样品 -C7烷基卤化物,或将样品与硅胶混合,然后用正相硅胶柱洗脱溶剂梯度洗脱硅胶柱,最后得到产物。