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11 条记录 (耗时 0.026 秒)

    Quinoline derivatives as neutrophil elastase inhibitors and their use
    4.
    发明申请
    Quinoline derivatives as neutrophil elastase inhibitors and their use 审中-公开
    喹啉衍生物作为嗜中性粒细胞弹性蛋白酶抑制剂及其应用

    公开(公告)号：US20070010551A1

    公开(公告)日：2007-01-11

    申请号：US10569571

    申请日：2004-08-25

    申请人： Hakan Bladh ,  Joakim Larsson

    发明人： Hakan Bladh ,  Joakim Larsson

    IPC分类号： A61K31/4704 ,  C07D215/233

    CPC分类号： C04B35/632 ,  C07D215/54 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

    摘要： There are provided novel compounds of formula (I) wherein R1, R3, R4, R5, G1, G2, L and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil elastase.

    摘要翻译： 提供式（I）的新化合物，其中R 1，R 3，R 4，R 5， ，G 1，G 2，L和n如本说明书和光学异构体，外消旋体和互变异构体及其药学上可接受的盐所定义; 以及其制备方法，含有它们的组合物及其在治疗中的用途。 这些化合物是嗜中性粒细胞弹性蛋白酶抑制剂。

    Method of measuring a capacitance
    6.
    发明授权
    Method of measuring a capacitance 有权
    测量电容的方法

    公开(公告)号：US09304096B2

    公开(公告)日：2016-04-05

    申请号：US13882641

    申请日：2011-10-31

    申请人： Dag Erlandsson ,  Martin Hedstrom ,  Bo Mattiasson ,  Joakim Larsson

    发明人： Dag Erlandsson ,  Martin Hedstrom ,  Bo Mattiasson ,  Joakim Larsson

    IPC分类号： G01R29/26 ,  G01N27/22 ,  G01N27/327 ,  G01R27/26

    CPC分类号： G01N27/22 ,  G01N27/228 ,  G01N27/3276 ,  G01R27/26 ,  G01R27/2605

    摘要： A method of measuring a capacitance (C) of a sensor having a working electrode that is coated by an insulating layer and a ligand forming an affinity surface. The method involves the steps of bringing the electrode into contact with an analyte, supplying a constant first current (I1), and a constant second current (I2) of opposite direction to the first current (I1), and a constant third current (I3) of same direction as the first current (I1) during determined time periods to the sensor. Further the method includes sampling the potential (V) built up across the sensor, and calculating the capacitance of the sensor from the inclination (B, D, F, H) of a potential curve received in response to the current supply. A method used for detection of an interaction between a ligand and an analyte is also disclosed.

    摘要翻译： 一种测量具有由绝缘层涂覆的工作电极和形成亲和表面的配体的传感器的电容（C）的方法。 该方法包括使电极与分析物接触的步骤，提供与第一电流（I1）相反方向的恒定的第一电流（I1）和恒定的第二电流（I2），以及恒定的第三电流（I3 ）与在传感器确定的时间段期间的与第一电流（I1）相同的方向。 此外，该方法包括对跨传感器建立的电位（V）进行采样，以及响应于当前电源接收的电位曲线的倾斜度（B，D，F，H）计算传感器的电容。 还公开了用于检测配体和分析物之间相互作用的方法。

    Sterilization device, sterilization process, vaporizing system and use of such vaporizing system
    7.
    发明授权
    Sterilization device, sterilization process, vaporizing system and use of such vaporizing system 有权
    灭菌装置，灭菌工艺，蒸发系统以及这种蒸发系统的使用

    公开(公告)号：US08372339B2

    公开(公告)日：2013-02-12

    申请号：US12449850

    申请日：2007-03-01

    申请人： Joakim Larsson ,  Bjarne Pedersen ,  Mats-Åke Åhlund ,  Stefan Nilsson

    发明人： Joakim Larsson ,  Bjarne Pedersen ,  Mats-Åke Åhlund ,  Stefan Nilsson

    IPC分类号： A61L9/00 ,  A62B7/08 ,  B03C3/16 ,  B01D46/00 ,  B01D50/00 ,  F24F13/078

    CPC分类号： A61L11/00 ,  A61L2/07 ,  A61L9/16 ,  A61L2202/122

    摘要： The invention discloses a sterilization device (1), to sterilize media, equipment and/or decontamination of waste material, said sterilization device (1) comprising a chamber (2), at least one exhaust line (6) arranged to said chamber (2) and at least one gas generator arranged to said chamber (2), at least two sterile filters (8a, 8b) arranged in series in the exhaust line (6), at least one vacuum means (7) connected to the chamber (2) via said exhaust line (6) and said at least two filters (8a, 8b). At least one heating means (9) is arranged to said exhaust line (6) between said two sterile filters (8a, 8b) in order to vaporize condensate that develops between the filters. Furthermore, it is disclosed a sterilization process for sterilization of media, equipment and/or decontamination of waste material, a vaporizing system (12) of a sterilization device and use of such a vaporizing system (12) in a sterilization device.

    摘要翻译： 本发明公开了一种灭菌装置（1），用于消毒废物的介质，设备和/或去污，所述灭菌装置（1）包括一个室（2），至少一个排放管线（6），布置在所述室 ）和布置在所述室（2）上的至少一个气体发生器，至少两个串联布置在排气管线（6）中的无菌过滤器（8a，8b），连接到室（2）的至少一个真空装置 ）通过所述排气管（6）和所述至少两个过滤器（8a，8b）。 至少一个加热装置（9）布置在所述两个无菌过滤器（8a，8b）之间的所述排气管线（6）上，以便蒸发在过滤器之间形成的冷凝物。 此外，公开了用于消毒废物的介质，设备和/或去污的灭菌方法，灭菌装置的蒸发系统（12）以及在消毒装置中使用这种蒸发系统（12）。

    METHOD OF MEASURING A CAPACITANCE
    8.
    发明申请
    METHOD OF MEASURING A CAPACITANCE 有权
    测量电容的方法

    公开(公告)号：US20130304397A1

    公开(公告)日：2013-11-14

    申请号：US13882641

    申请日：2011-10-31

    申请人： Dag Erlandsson ,  Martin Hedstrom ,  Bo Mattiasson ,  Joakim Larsson

    发明人： Dag Erlandsson ,  Martin Hedstrom ,  Bo Mattiasson ,  Joakim Larsson

    IPC分类号： G01N27/22 ,  G01R27/26

    CPC分类号： G01N27/22 ,  G01N27/228 ,  G01N27/3276 ,  G01R27/26 ,  G01R27/2605

    摘要： A method of measuring a capacitance (C) of a sensor having a working electrode that is coated by an insulating layer and a ligand forming an affinity surface. The method involves the steps of bringing the electrode into contact with an analyte, supplying a constant first current (I1), and a constant second current (I2) of opposite direction to the first current (I1), and a constant third current (I3) of same direction as the first current (I1) during determined time periods to the sensor. Further the method includes sampling the potential (V) built up across the sensor, and calculating the capacitance of the sensor from the inclination (B, D, F, H) of a potential curve received in response to the current supply. A method used for detection of an interaction between a ligand and an analyte is also disclosed.

    摘要翻译： 一种测量具有由绝缘层涂覆的工作电极和形成亲和表面的配体的传感器的电容（C）的方法。 该方法包括使电极与分析物接触的步骤，提供与第一电流（I1）相反方向的恒定的第一电流（I1）和恒定的第二电流（I2），以及恒定的第三电流（I3 ）与在传感器确定的时间段期间的与第一电流（I1）相同的方向。 此外，该方法包括对跨传感器建立的电位（V）进行采样，以及响应于当前电源接收的电位曲线的倾斜度（B，D，F，H）计算传感器的电容。 还公开了用于检测配体和分析物之间相互作用的方法。

    STERILIZATION DEVICE, STERILIZATION PROCESS, VAPORIZING SYSTEM AND USE OF SUCH VAPORIZING SYSTEM
    9.
    发明申请
    STERILIZATION DEVICE, STERILIZATION PROCESS, VAPORIZING SYSTEM AND USE OF SUCH VAPORIZING SYSTEM 有权
    灭菌装置，灭菌过程，蒸发系统和这种蒸发系统的使用

    公开(公告)号：US20100086438A1

    公开(公告)日：2010-04-08

    申请号：US12449850

    申请日：2007-03-01

    申请人： Joakim Larsson ,  Bjarne Pedersen ,  Mats-Åke Åhlund ,  Stefan Nilsson

    发明人： Joakim Larsson ,  Bjarne Pedersen ,  Mats-Åke Åhlund ,  Stefan Nilsson

    IPC分类号： A61L2/07 ,  A61L11/00 ,  B01D35/18

    CPC分类号： A61L11/00 ,  A61L2/07 ,  A61L9/16 ,  A61L2202/122

    摘要： The invention discloses a sterilization device (1), to sterilize media, equipment and/or decontamination of waste material, said sterilization device (1) comprising a chamber (2), at least one exhaust line (6) arranged to said chamber (2) and at least one gas generator arranged to said chamber (2), at least two sterile filters (8a, 8b) arranged in series in the exhaust line (6), at least one vacuum means (7) connected to the chamber (2) via said exhaust line (6) and said at least two filters (8a, 8b). At least one heating means (9) is arranged to said exhaust line (6) between said two sterile filters (8a, 8b) in order to vaporize condensate that develops between the filters. Furthermore, it is disclosed a sterilization process for sterilization of media, equipment and/or decontamination of waste material, a vaporizing system (12) of a sterilization device and use of such a vaporizing system (12) in a sterilization device.

    摘要翻译： 本发明公开了一种灭菌装置（1），用于消毒废物的介质，设备和/或去污，所述灭菌装置（1）包括一个室（2），至少一个排放管线（6），布置在所述室 ）和布置在所述室（2）上的至少一个气体发生器，至少两个串联布置在排气管线（6）中的无菌过滤器（8a，8b），连接到室（2）的至少一个真空装置 ）通过所述排气管（6）和所述至少两个过滤器（8a，8b）。 至少一个加热装置（9）布置在所述两个无菌过滤器（8a，8b）之间的所述排气管线（6）上，以便蒸发在过滤器之间形成的冷凝物。 此外，公开了用于消毒废物的介质，设备和/或去污的灭菌方法，灭菌装置的蒸发系统（12）以及在消毒装置中使用这种蒸发系统（12）。