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1.发明授权1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators 有权1-苯基取代的杂环基衍生物及其作为前列腺素D2受体调节剂的用途公开(公告)号：US08575158B2
公开(公告)日：2013-11-05
申请号：US13808857
申请日：2011-07-04
申请人： Hamed Aissaoui , Christoph Boss , Heinz Fretz , Julien Pothier , Sylvia Richard-Bildstein , Philippe Risch , Romain Siegrist
发明人： Hamed Aissaoui , Christoph Boss , Heinz Fretz , Julien Pothier , Sylvia Richard-Bildstein , Philippe Risch , Romain Siegrist
IPC分类号： C07D265/36 , C07D221/04
CPC分类号： C07D487/04 , A61K31/4035 , A61K31/472 , C07D209/44 , C07D217/16 , C07D217/26 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D417/12 , C07D471/04
摘要： The present invention relates to 1-phenyl-substituted heterocyclyl derivatives of the formula (I), wherein X, Y, Z, n, R1, R2, R3, R4, R5, R6, R7 and R10 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
摘要翻译： 本发明涉及式（I）的1-苯基取代的杂环基衍生物，其中X，Y，Z，n，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 10如说明书和 其用作前列腺素受体调节剂，最特别地作为前列腺素D2受体调节剂用于治疗各种前列腺素介导的疾病和病症，含有这些化合物的药物组合物及其制备方法。
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2.发明申请1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS 有权1-苯基取代的杂环衍生物及其作为PROSTAGLANDIN D2受体调节剂的用途公开(公告)号：US20130109685A1
公开(公告)日：2013-05-02
申请号：US13808857
申请日：2011-07-04
申请人： Hamed Aissaoui , Christoph Boss , Anja Valdenaire , Julien Pothier , Sylvia Richard-Bildstein , Philippe Risch , Romain Siegrist
发明人： Hamed Aissaoui , Christoph Boss , Anja Valdenaire , Julien Pothier , Sylvia Richard-Bildstein , Philippe Risch , Romain Siegrist
IPC分类号： C07D487/04 , C07D417/06 , C07D405/04 , C07D417/12 , C07D401/12 , C07D471/04 , C07D217/26 , C07D413/06
CPC分类号： C07D487/04 , A61K31/4035 , A61K31/472 , C07D209/44 , C07D217/16 , C07D217/26 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D417/12 , C07D471/04
摘要： The present invention relates to 1-phenyl-substituted heterocyclyl derivatives of the formula (I), wherein X, Y, Z, n, R1, R2, R3, R4, R5, R6, R7 and R10 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
摘要翻译： 本发明涉及式（I）的1-苯基取代的杂环基衍生物，其中X，Y，Z，n，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 10如说明书和 其用作前列腺素受体调节剂，最特别地作为前列腺素D2受体调节剂用于治疗各种前列腺素介导的疾病和病症，含有这些化合物的药物组合物及其制备方法。
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3.发明申请(3-Amino-1,2,3,4-Tetrahydro-9H-Carbazol-9-yl)-Acetic Acid Derivatives 有权（3-氨基-1,2,3,4-四氢-9H-咔唑-9-基） - 乙酸衍生物公开(公告)号：US20100190830A1
公开(公告)日：2010-07-29
申请号：US12376932
申请日：2007-08-02
申请人： Heinz Fretz , Julien Pothier , Philippe Risch
发明人： Heinz Fretz , Julien Pothier , Philippe Risch
IPC分类号： A61K31/4439 , C07D209/88 , A61K31/403 , A61P35/02 , A61P11/06 , A61P27/14 , A61P29/00 , A61P13/12 , A61P17/00 , A61P37/08 , A61P17/04 , A61P9/10 , A61P1/04 , C07D403/12 , A61K31/4184 , C07D401/12
CPC分类号： C07D209/88
摘要： The present invention relates to (3-amino-1,2,3,4-tetrahydro-9H-carbazol-9-yl)-acetic acid derivatives of Formula (I) wherein R1, R2, R3, R4, R5 and R6 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
摘要翻译： 本发明涉及式（I）的（3-氨基-1,2,3,4-四氢-9H-咔唑-9-基） - 乙酸衍生物，其中R 1，R 2，R 3，R 4，R 5和R 6是 如在描述中所描述的，以及它们作为前列腺素受体调节剂的用途，最特别地作为前列腺素D2受体调节剂在治疗各种前列腺素介导的疾病和病症中的用途，含有这些化合物的药物组合物及其制备方法。
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4.发明授权(3-amino-1,2,3,4-tetrahydro-9 H-carbazol-9-yl)-acetic acid derivatives 有权（3-氨基-1,2,3,4-四氢-9H-咔唑-9-基） - 乙酸衍生物公开(公告)号：US08143304B2
公开(公告)日：2012-03-27
申请号：US12376932
申请日：2007-08-02
申请人： Heinz Fretz , Julien Pothier , Philippe Risch
发明人： Heinz Fretz , Julien Pothier , Philippe Risch
IPC分类号： A01N43/38 , A61K31/40 , C07C49/00 , C07D209/94 , C07D487/00 , C07D491/00 , C07D513/00
CPC分类号： C07D209/88
摘要： The present invention relates to (3-amino-1,2,3,4-tetrahydro-9H-carbazol-9-yl)-acetic acid derivatives of Formula (I) wherein R1, R2, R3, R4, R5 and R6 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
摘要翻译： 本发明涉及式（I）的（3-氨基-1,2,3,4-四氢-9H-咔唑-9-基） - 乙酸衍生物，其中R 1，R 2，R 3，R 4，R 5和R 6是 如在描述中所描述的，以及它们作为前列腺素受体调节剂的用途，最特别地作为前列腺素D2受体调节剂在治疗各种前列腺素介导的疾病和病症中的用途，含有这些化合物的药物组合物及其制备方法。
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