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1.发明授权Human SLAP-2: a novel SH2/ SH3 domain-containing human SLAP homologue having immune cell-specific expression 有权人类SLAP-2：具有免疫细胞特异性表达的新型SH2 / SH3结构域的人SLAP同源物公开(公告)号：US07517957B2
公开(公告)日：2009-04-14
申请号：US11429515
申请日：2006-05-05
申请人： Han Chang , Wen-Pin Yang , Yuli Wu , Gena S. Whitney , Juan J. Perez-villar , Steven B. Kanner
发明人： Han Chang , Wen-Pin Yang , Yuli Wu , Gena S. Whitney , Juan J. Perez-villar , Steven B. Kanner
IPC分类号： C07K14/00
摘要： The present invention describes a newly discovered full-length polynucleotide encoding an SH2/SH3 domain-containing adapter protein, called hSLAP-2, cloned, isolated and identified. Also described are the hSLAP-2 polypeptide sequence, expression vectors, host cells, agonists, antagonists, anti-sense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the hSLAP-2 protein and use of the hSLAP-2 polynucleotide and polypeptide for therapeutics and diagnostics are described.
摘要翻译： 本发明描述了新发现的编码含有SH2 / SH3结构域的衔接蛋白（称为hSLAP-2）的克隆，分离和鉴定的全长多核苷酸。 还描述了与本发明的多核苷酸和/或多肽相关的hSLAP-2多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 描述了用于筛选hSLAP-2蛋白的调节剂，特别是抑制剂的方法以及hSLAP-2多核苷酸和多肽用于治疗和诊断的方法。
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2.发明授权Polynucleotides encoding human SLAP-2:a novel SH2/SH3 domain-containing human SLAP homologue having immune cell-specific expression 有权编码人SLAP-2的多核苷酸：具有免疫细胞特异性表达的新型含SH2 / SH3结构域的人SLAP同源物公开(公告)号：US07101686B1
公开(公告)日：2006-09-05
申请号：US09988971
申请日：2001-11-20
申请人： Han Chang , Wen-Pin Yang , Yuli Wu , Gena S. Whitney , Juan J. Perez-villar , Steven B. Kanner
发明人： Han Chang , Wen-Pin Yang , Yuli Wu , Gena S. Whitney , Juan J. Perez-villar , Steven B. Kanner
CPC分类号： C07K14/47
摘要： The present invention describes a newly discovered full-length polynucleotide encoding an SH2/SH3 domain-containing adapter protein, called hSLAP-2, cloned, isolated and identified. Also described are the hSLAP-2 polypeptide sequence, expression vectors, host cells, agonists, antagonists, anti-sense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the hSLAP-2 protein and use of the hSLAP-2 polynucleotide and polypeptide for therapeutics and diagnostics are described.
摘要翻译： 本发明描述了新发现的编码含有SH2 / SH3结构域的衔接蛋白（称为hSLAP-2）的克隆，分离和鉴定的全长多核苷酸。 还描述了与本发明的多核苷酸和/或多肽相关的hSLAP-2多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 描述了用于筛选hSLAP-2蛋白的调节剂，特别是抑制剂的方法以及hSLAP-2多核苷酸和多肽用于治疗和诊断的方法。
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3.发明授权Antibody directed to human mist (mast cell immunoreceptor signal transducer) 有权针对人类雾的抗体（肥大细胞免疫受体信号转导体）公开(公告)号：US07667003B2
公开(公告)日：2010-02-23
申请号：US12231623
申请日：2008-09-04
申请人： Juan J. Perez-Villar , Han Chang , Steven B. Kanner , Gena S. Whitney , Yuli Wu , Wen-Pin Yang
发明人： Juan J. Perez-Villar , Han Chang , Steven B. Kanner , Gena S. Whitney , Yuli Wu , Wen-Pin Yang
IPC分类号： C07K16/28
CPC分类号： C07K14/47 , A01K2217/05 , Y10S435/81
摘要： The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Novel splice variant forms of human MIST are provided. Methods for screening for modulators, particularly inhibitors, of the MIST protein and use of the human MIST polynucleotide and polypeptide for therapeutics and diagnostics are described.
摘要翻译： 本发明描述了一种新发现的全长多核苷酸，其编码含有SH2结构域的衔接蛋白，称为人MIST，从人脾cDNA文库克隆，分离和鉴定。 还描述了与本发明的多核苷酸和/或多肽相关的MIST多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 提供人类MIST的新型剪接变体形式。 描述了用于筛选MIST蛋白的调节剂，特别是抑制剂的方法以及人MIST多核苷酸和多肽用于治疗和诊断的用途。
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4.发明申请Identification and cloning of a full-length human CLNK-related gene, MIST (MAST cell immunoreceptor signal transducer) 有权鉴定和克隆全长人类CLNK相关基因MIST（MAST细胞免疫受体信号转导子）公开(公告)号：US20090042226A1
公开(公告)日：2009-02-12
申请号：US12231623
申请日：2008-09-04
申请人： Juan J. Perez-Villar , Han Chang , Steven B. Kanner , Gena S. Whitney , Yuli Wu , Wen-Pin Yang
发明人： Juan J. Perez-Villar , Han Chang , Steven B. Kanner , Gena S. Whitney , Yuli Wu , Wen-Pin Yang
CPC分类号： C07K14/47 , A01K2217/05 , Y10S435/81
摘要： The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Novel splice variant forms of human MIST are provided. Methods for screening for modulators, particularly inhibitors, of the MIST protein and use of the human MIST polynucleotide and polypeptide for therapeutics and diagnostics are described.
摘要翻译： 本发明描述了一种新发现的全长多核苷酸，其编码含有SH2结构域的衔接蛋白，称为人MIST，从人脾cDNA文库克隆，分离和鉴定。 还描述了与本发明的多核苷酸和/或多肽相关的MIST多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 提供人类MIST的新型剪接变体形式。 描述了用于筛选MIST蛋白的调节剂，特别是抑制剂的方法以及人MIST多核苷酸和多肽用于治疗和诊断的用途。
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5.发明授权Human clnk-related polypeptide, MIST (Mast Cell Immunoreceptor Signal Transducer) 有权人类相关多肽MIST（Mast Cell Immunoreceptor Signal Transducer）公开(公告)号：US07442770B2
公开(公告)日：2008-10-28
申请号：US11640775
申请日：2006-12-18
申请人： Juan J. Perez-Villar , Han Chang , Wen-Pin Yang , Yuli Wu , Gena S. Whitney , Steven B. Kanner
发明人： Juan J. Perez-Villar , Han Chang , Wen-Pin Yang , Yuli Wu , Gena S. Whitney , Steven B. Kanner
IPC分类号： C07K14/435 , C12N15/12 , C12N15/63
CPC分类号： C07K14/47 , A01K2217/05 , Y10S435/81
摘要： The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Novel splice variant forms of human MIST are provided. Methods for screening for modulators, particularly inhibitors, of the MIST protein and use of the human MIST polynucleotide and polypeptide for therapeutics and diagnostics are described.
摘要翻译： 本发明描述了一种新发现的全长多核苷酸，其编码含有SH2结构域的衔接蛋白，称为人MIST，从人脾cDNA文库克隆，分离和鉴定。 还描述了与本发明的多核苷酸和/或多肽相关的MIST多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 提供人类MIST的新型剪接变体形式。 描述了用于筛选MIST蛋白的调节剂，特别是抑制剂的方法以及人MIST多核苷酸和多肽用于治疗和诊断的用途。
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6.发明授权Identification and cloning of a full-length human Clnk-related gene, MIST (mast cell immunoreceptor signal transducer) 有权鉴定和克隆全长人类Clnk相关基因MIST（肥大细胞免疫受体信号转导子）公开(公告)号：US07241590B2
公开(公告)日：2007-07-10
申请号：US09966955
申请日：2001-09-28
申请人： Juan J. Perez-Villar , Han Chang , Wen-Pin Yang , Yuli Wu , Gena S. Whitney , Steven B. Kanner
发明人： Juan J. Perez-Villar , Han Chang , Wen-Pin Yang , Yuli Wu , Gena S. Whitney , Steven B. Kanner
CPC分类号： C07K14/47 , A01K2217/05 , Y10S435/81
摘要： The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Novel splice variant forms of human MIST are provided. Methods for screening for modulators, particularly inhibitors, of the MIST protein and use of the human MIST polynucleotide and polypeptide for therapeutics and diagnostics are described.
摘要翻译： 本发明描述了一种新发现的全长多核苷酸，其编码含有SH2结构域的衔接蛋白，称为人MIST，从人脾cDNA文库克隆，分离和鉴定。 还描述了与本发明的多核苷酸和/或多肽相关的MIST多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 提供人类MIST的新型剪接变体形式。 描述了用于筛选MIST蛋白的调节剂，特别是抑制剂的方法以及人MIST多核苷酸和多肽用于治疗和诊断的用途。
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7.发明申请Identification and cloning of a full-length human clnk-related gene, MIST (mast cell immunoreceptor signal transducer) 有权鉴定和克隆全长人类clnk相关基因MIST（肥大细胞免疫受体信号转导子）公开(公告)号：US20070117141A1
公开(公告)日：2007-05-24
申请号：US11640775
申请日：2006-12-18
申请人： Juan Perez-Villar , Han Chang , Wen-Pin Yang , Yuli Wu , Gena Whitney , Steven Kanner
发明人： Juan Perez-Villar , Han Chang , Wen-Pin Yang , Yuli Wu , Gena Whitney , Steven Kanner
CPC分类号： C07K14/47 , A01K2217/05 , Y10S435/81
摘要： The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Novel splice variant forms of human MIST are provided. Methods for screening for modulators, particularly inhibitors, of the MIST protein and use of the human MIST polynucleotide and polypeptide for therapeutics and diagnostics are described.
摘要翻译： 本发明描述了一种新发现的全长多核苷酸，其编码含有SH2结构域的衔接蛋白，称为人MIST，从人脾cDNA文库克隆，分离和鉴定。 还描述了与本发明的多核苷酸和/或多肽相关的MIST多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 提供人类MIST的新型剪接变体形式。 描述了用于筛选MIST蛋白的调节剂，特别是抑制剂的方法以及人MIST多核苷酸和多肽用于治疗和诊断的用途。
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8.发明申请Cloning and expression of human SLAP-2: a novel SH2/ SH3 domain-containing human SLAP homologue having immune cell-specific expression 有权人SLAP-2的克隆和表达：具有免疫细胞特异性表达的新型SH2 / SH3结构域的人SLAP同源物公开(公告)号：US20060193858A1
公开(公告)日：2006-08-31
申请号：US11429515
申请日：2006-05-05
申请人： Han Chang , Wen-Pin Yang , Yuli Wu , Gena Whitney , Juan Perez-villar , Steven Kanner
发明人： Han Chang , Wen-Pin Yang , Yuli Wu , Gena Whitney , Juan Perez-villar , Steven Kanner
IPC分类号： A61K48/00 , C07H21/04 , C12P21/06 , A61K39/395 , C07K16/28
摘要： The present invention describes a newly discovered full-length polynucleotide encoding an SH2/SH3 domain-containing adapter protein, called hSLAP-2, cloned, isolated and identified. Also described are the hSLAP-2 polypeptide sequence, expression vectors, host cells, agonists, antagonists, anti-sense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the hSLAP-2 protein and use of the hSLAP-2 polynucleotide and polypeptide for therapeutics and diagnostics are described.
摘要翻译： 本发明描述了新发现的编码含有SH2 / SH3结构域的衔接蛋白（称为hSLAP-2）的克隆，分离和鉴定的全长多核苷酸。 还描述了与本发明的多核苷酸和/或多肽相关的hSLAP-2多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 描述了用于筛选hSLAP-2蛋白的调节剂，特别是抑制剂的方法以及hSLAP-2多核苷酸和多肽用于治疗和诊断的方法。
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公开(公告)号：US08354513B2
公开(公告)日：2013-01-15
申请号：US12783968
申请日：2010-05-20
IPC分类号： C07H21/04
CPC分类号： C07K14/70532 , A61K38/00 , A61K38/1774 , A61K39/39533 , A61K2039/505 , C07K16/2827 , C07K19/00 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/10 , C07K2319/30 , C07K2319/40 , G01N33/5005 , Y02A50/396
摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.
摘要翻译： 本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。 还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。 本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。 此外，本发明提供利用B7相关核酸，多肽或肽的测定法。 本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。
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10.发明授权Polypeptide for a TRP channel family member, TRP-PLIK2, and splice variants 有权用于TRP通道家族成员的多肽，TRP-PLIK2和剪接变体公开(公告)号：US07541434B2
公开(公告)日：2009-06-02
申请号：US11726234
申请日：2007-03-21
申请人： Ning Lee , Jian Chen , Shujian Wu , Han Chang , Michael A. Blanar
发明人： Ning Lee , Jian Chen , Shujian Wu , Han Chang , Michael A. Blanar
CPC分类号： C07K14/705
摘要： The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码TRP-PLIK2多肽的新型多核苷酸，其片段及其同源物。 本发明还提供分别编码TRP-PLIK2多肽，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d的变体和剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型TRP-PLIK2，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d多肽应用于诊断，治疗和/或预防与这些相关的各种疾病和/或病症的诊断和治疗方法 多肽。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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