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41 条记录 (耗时 0.042 秒)

    Antibody directed to human mist (mast cell immunoreceptor signal transducer)
    1.
    发明授权
    Antibody directed to human mist (mast cell immunoreceptor signal transducer) 有权
    针对人类雾的抗体（肥大细胞免疫受体信号转导体）

    公开(公告)号：US07667003B2

    公开(公告)日：2010-02-23

    申请号：US12231623

    申请日：2008-09-04

    申请人： Juan J. Perez-Villar ,  Han Chang ,  Steven B. Kanner ,  Gena S. Whitney ,  Yuli Wu ,  Wen-Pin Yang

    发明人： Juan J. Perez-Villar ,  Han Chang ,  Steven B. Kanner ,  Gena S. Whitney ,  Yuli Wu ,  Wen-Pin Yang

    IPC分类号： C07K16/28

    CPC分类号： C07K14/47 ,  A01K2217/05 ,  Y10S435/81

    摘要： The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Novel splice variant forms of human MIST are provided. Methods for screening for modulators, particularly inhibitors, of the MIST protein and use of the human MIST polynucleotide and polypeptide for therapeutics and diagnostics are described.

    摘要翻译： 本发明描述了一种新发现的全长多核苷酸，其编码含有SH2结构域的衔接蛋白，称为人MIST，从人脾cDNA文库克隆，分离和鉴定。 还描述了与本发明的多核苷酸和/或多肽相关的MIST多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 提供人类MIST的新型剪接变体形式。 描述了用于筛选MIST蛋白的调节剂，特别是抑制剂的方法以及人MIST多核苷酸和多肽用于治疗和诊断的用途。

    Human SLAP-2: a novel SH2/ SH3 domain-containing human SLAP homologue having immune cell-specific expression
    2.
    发明授权
    Human SLAP-2: a novel SH2/ SH3 domain-containing human SLAP homologue having immune cell-specific expression 有权
    人类SLAP-2：具有免疫细胞特异性表达的新型SH2 / SH3结构域的人SLAP同源物

    公开(公告)号：US07517957B2

    公开(公告)日：2009-04-14

    申请号：US11429515

    申请日：2006-05-05

    申请人： Han Chang ,  Wen-Pin Yang ,  Yuli Wu ,  Gena S. Whitney ,  Juan J. Perez-villar ,  Steven B. Kanner

    发明人： Han Chang ,  Wen-Pin Yang ,  Yuli Wu ,  Gena S. Whitney ,  Juan J. Perez-villar ,  Steven B. Kanner

    IPC分类号： C07K14/00

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention describes a newly discovered full-length polynucleotide encoding an SH2/SH3 domain-containing adapter protein, called hSLAP-2, cloned, isolated and identified. Also described are the hSLAP-2 polypeptide sequence, expression vectors, host cells, agonists, antagonists, anti-sense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the hSLAP-2 protein and use of the hSLAP-2 polynucleotide and polypeptide for therapeutics and diagnostics are described.

    摘要翻译： 本发明描述了新发现的编码含有SH2 / SH3结构域的衔接蛋白（称为hSLAP-2）的克隆，分离和鉴定的全长多核苷酸。 还描述了与本发明的多核苷酸和/或多肽相关的hSLAP-2多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 描述了用于筛选hSLAP-2蛋白的调节剂，特别是抑制剂的方法以及hSLAP-2多核苷酸和多肽用于治疗和诊断的方法。

    Identification and cloning of a full-length human CLNK-related gene, MIST (MAST cell immunoreceptor signal transducer)
    4.
    发明申请
    Identification and cloning of a full-length human CLNK-related gene, MIST (MAST cell immunoreceptor signal transducer) 有权
    鉴定和克隆全长人类CLNK相关基因MIST（MAST细胞免疫受体信号转导子）

    公开(公告)号：US20090042226A1

    公开(公告)日：2009-02-12

    申请号：US12231623

    申请日：2008-09-04

    申请人： Juan J. Perez-Villar ,  Han Chang ,  Steven B. Kanner ,  Gena S. Whitney ,  Yuli Wu ,  Wen-Pin Yang

    发明人： Juan J. Perez-Villar ,  Han Chang ,  Steven B. Kanner ,  Gena S. Whitney ,  Yuli Wu ,  Wen-Pin Yang

    IPC分类号： G01N33/53 ,  C07K16/18 ,  C12N5/06 ,  C12N9/00

    CPC分类号： C07K14/47 ,  A01K2217/05 ,  Y10S435/81

    摘要： The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Novel splice variant forms of human MIST are provided. Methods for screening for modulators, particularly inhibitors, of the MIST protein and use of the human MIST polynucleotide and polypeptide for therapeutics and diagnostics are described.

    摘要翻译： 本发明描述了一种新发现的全长多核苷酸，其编码含有SH2结构域的衔接蛋白，称为人MIST，从人脾cDNA文库克隆，分离和鉴定。 还描述了与本发明的多核苷酸和/或多肽相关的MIST多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 提供人类MIST的新型剪接变体形式。 描述了用于筛选MIST蛋白的调节剂，特别是抑制剂的方法以及人MIST多核苷酸和多肽用于治疗和诊断的用途。

    Human clnk-related polypeptide, MIST (Mast Cell Immunoreceptor Signal Transducer)
    5.
    发明授权
    Human clnk-related polypeptide, MIST (Mast Cell Immunoreceptor Signal Transducer) 有权
    人类相关多肽MIST（Mast Cell Immunoreceptor Signal Transducer）

    公开(公告)号：US07442770B2

    公开(公告)日：2008-10-28

    申请号：US11640775

    申请日：2006-12-18

    申请人： Juan J. Perez-Villar ,  Han Chang ,  Wen-Pin Yang ,  Yuli Wu ,  Gena S. Whitney ,  Steven B. Kanner

    发明人： Juan J. Perez-Villar ,  Han Chang ,  Wen-Pin Yang ,  Yuli Wu ,  Gena S. Whitney ,  Steven B. Kanner

    IPC分类号： C07K14/435 ,  C12N15/12 ,  C12N15/63

    CPC分类号： C07K14/47 ,  A01K2217/05 ,  Y10S435/81

    摘要： The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Novel splice variant forms of human MIST are provided. Methods for screening for modulators, particularly inhibitors, of the MIST protein and use of the human MIST polynucleotide and polypeptide for therapeutics and diagnostics are described.

    摘要翻译： 本发明描述了一种新发现的全长多核苷酸，其编码含有SH2结构域的衔接蛋白，称为人MIST，从人脾cDNA文库克隆，分离和鉴定。 还描述了与本发明的多核苷酸和/或多肽相关的MIST多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 提供人类MIST的新型剪接变体形式。 描述了用于筛选MIST蛋白的调节剂，特别是抑制剂的方法以及人MIST多核苷酸和多肽用于治疗和诊断的用途。

    Identification and cloning of a full-length human Clnk-related gene, MIST (mast cell immunoreceptor signal transducer)
    6.
    发明授权
    Identification and cloning of a full-length human Clnk-related gene, MIST (mast cell immunoreceptor signal transducer) 有权
    鉴定和克隆全长人类Clnk相关基因MIST（肥大细胞免疫受体信号转导子）

    公开(公告)号：US07241590B2

    公开(公告)日：2007-07-10

    申请号：US09966955

    申请日：2001-09-28

    申请人： Juan J. Perez-Villar ,  Han Chang ,  Wen-Pin Yang ,  Yuli Wu ,  Gena S. Whitney ,  Steven B. Kanner

    发明人： Juan J. Perez-Villar ,  Han Chang ,  Wen-Pin Yang ,  Yuli Wu ,  Gena S. Whitney ,  Steven B. Kanner

    IPC分类号： C12N5/10 ,  C12N15/12 ,  C12N15/62 ,  C12N15/63

    CPC分类号： C07K14/47 ,  A01K2217/05 ,  Y10S435/81

    摘要： The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Novel splice variant forms of human MIST are provided. Methods for screening for modulators, particularly inhibitors, of the MIST protein and use of the human MIST polynucleotide and polypeptide for therapeutics and diagnostics are described.

    摘要翻译： 本发明描述了一种新发现的全长多核苷酸，其编码含有SH2结构域的衔接蛋白，称为人MIST，从人脾cDNA文库克隆，分离和鉴定。 还描述了与本发明的多核苷酸和/或多肽相关的MIST多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 提供人类MIST的新型剪接变体形式。 描述了用于筛选MIST蛋白的调节剂，特别是抑制剂的方法以及人MIST多核苷酸和多肽用于治疗和诊断的用途。

    Identification and cloning of a full-length human clnk-related gene, MIST (mast cell immunoreceptor signal transducer)
    8.
    发明申请
    Identification and cloning of a full-length human clnk-related gene, MIST (mast cell immunoreceptor signal transducer) 有权
    鉴定和克隆全长人类clnk相关基因MIST（肥大细胞免疫受体信号转导子）

    公开(公告)号：US20070117141A1

    公开(公告)日：2007-05-24

    申请号：US11640775

    申请日：2006-12-18

    申请人： Juan Perez-Villar ,  Han Chang ,  Wen-Pin Yang ,  Yuli Wu ,  Gena Whitney ,  Steven Kanner

    发明人： Juan Perez-Villar ,  Han Chang ,  Wen-Pin Yang ,  Yuli Wu ,  Gena Whitney ,  Steven Kanner

    IPC分类号： C12Q1/68 ,  A61K38/17 ,  C07K14/705 ,  C07K16/28 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/47 ,  A01K2217/05 ,  Y10S435/81

    摘要： The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Novel splice variant forms of human MIST are provided. Methods for screening for modulators, particularly inhibitors, of the MIST protein and use of the human MIST polynucleotide and polypeptide for therapeutics and diagnostics are described.

    摘要翻译： 本发明描述了一种新发现的全长多核苷酸，其编码含有SH2结构域的衔接蛋白，称为人MIST，从人脾cDNA文库克隆，分离和鉴定。 还描述了与本发明的多核苷酸和/或多肽相关的MIST多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 提供人类MIST的新型剪接变体形式。 描述了用于筛选MIST蛋白的调节剂，特别是抑制剂的方法以及人MIST多核苷酸和多肽用于治疗和诊断的用途。