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公开(公告)号：US20130211182A1
公开(公告)日：2013-08-15
申请号：US13742322
申请日：2013-01-15
申请人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
发明人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
IPC分类号： A61F2/24
CPC分类号： A61F2/2478 , A61B17/00491 , A61B17/12022 , A61B17/12045 , A61B17/12122 , A61B17/12136 , A61B17/12181 , A61B17/12186 , A61B17/1219 , A61B2017/00243 , A61B2017/048 , A61B2017/1205 , A61B2017/12127 , A61F2/2481 , A61F2002/249 , A61F2250/0067 , A61L31/005
摘要： Cardiomyopathy may be treated by distributing a space-occupying diastole-assist agent within the myocardium or within the cardiac venous system in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress, stabilize or even reduce chamber size, and/or improve diastolic function. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Patterns of distribution of space-occupying agent within the myocardium for global resizing may also be used or augmented to treat localized conditions such as myocardial infarctions, overt aneurysm of the ventricular wall as typically forms in response to large transmural myocardial infarctions, and mitral regurgitation due to a noncompliant mitral valve. These techniques may also be used to treat localized conditions that may not yet have progressed to cardiomyopathy.
摘要翻译： 心肌病可以通过以围绕心脏的一个或多个腔室的模式在心肌内或心脏静脉系统内分布空间占据舒张辅助剂来治疗，使得空间改变剂整合入并增稠至少部分 围绕腔室的心脏壁，以便全局地减小壁应力，稳定或甚至减小腔室尺寸，和/或改善舒张功能。 一些模式也引起了对室的有益的全局整形。 这些变化迅速发生并且是可持续的，并且对心脏功能具有快速和可持续的治疗作用。 用于全局调整大小的心肌内的空间占位剂的分布模式也可以被使用或增加以治疗局部的情况，例如心肌梗死，通常形成响应于大的透壁性心肌梗死的心室壁的明显的动脉瘤和二尖瓣反流 到不合规的二尖瓣。 这些技术也可用于治疗可能尚未进展为心肌病的局部病症。
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公开(公告)号：US09375313B2
公开(公告)日：2016-06-28
申请号：US11899962
申请日：2007-09-07
申请人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
发明人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
CPC分类号： A61F2/2451 , A61F2/2481 , A61F2002/249 , A61F2250/0067 , A61K9/0024 , A61L27/20 , A61L27/3873 , A61L27/52 , A61L2400/06 , A61M5/14 , A61M5/178 , A61M37/00 , A61M37/0069
摘要： Cardiomyopathy may be treated by distributing space-occupying agent within the myocardium in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress and stabilize or even reduce chamber size. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Over time the relief of wall stress reduces oxygen consumption and promotes healing. Moreover, various long-term therapeutic effects may be realized depending on the properties of the space-occupying agent, including combinations with other therapeutic materials. These techniques may also be used to treat localized conditions, whether or not they have progressed to cardiomyopathy.
摘要翻译： 心肌病可以通过以围绕心脏的一个或多个腔室的模式在心肌内分布空间占位剂来治疗，使得空间改变剂整合到腔室周围的至少部分心脏壁并使其增厚， 降低壁面应力，稳定或甚至减小腔室尺寸。 一些模式也引起了对室的有益的全局整形。 这些变化迅速发生并且是可持续的，并且对心脏功能具有快速和可持续的治疗作用。 随着时间的推移，墙壁压力的减轻会降低氧气消耗并促进愈合。 此外，根据空间占据剂的特性，包括与其它治疗材料的组合，可以实现各种长期治疗效果。 这些技术也可用于治疗局部的病症，无论其是否进展为心肌病。
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公开(公告)号：US20090012413A1
公开(公告)日：2009-01-08
申请号：US12157711
申请日：2008-06-11
申请人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
发明人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
CPC分类号： A61F2/2478 , A61B17/00491 , A61B17/12022 , A61B17/12045 , A61B17/12122 , A61B17/12136 , A61B17/12181 , A61B17/12186 , A61B17/1219 , A61B2017/00243 , A61B2017/048 , A61B2017/1205 , A61B2017/12127 , A61F2/2481 , A61F2002/249 , A61F2250/0067 , A61L31/005
摘要： Cardiomyopathy may be treated by distributing a space-occupying diastole-assist agent within the myocardium or within the cardiac venous system in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress, stabilize or even reduce chamber size, and/or improve diastolic function. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Patterns of distribution of space-occupying agent within the myocardium for global resizing may also be used or augmented to treat localized conditions such as myocardial infarctions, overt aneurysm of the ventricular wall as typically forms in response to large transmural myocardial infarctions, and mitral regurgitation due to a noncompliant mitral valve. These techniques may also be used to treat localized conditions that may not yet have progressed to cardiomyopathy.
摘要翻译： 心肌病可以通过以围绕心脏的一个或多个腔室的模式在心肌内或心脏静脉系统内分布空间占据舒张辅助剂来治疗，使得空间改变剂整合入并增稠至少部分 围绕腔室的心脏壁，以便全局地减小壁应力，稳定或甚至减小腔室尺寸，和/或改善舒张功能。 一些模式也引起了对室的有益的全局整形。 这些变化迅速发生并且是可持续的，并且对心脏功能具有快速和可持续的治疗作用。 用于全局调整大小的心肌内的空间占位剂的分布模式也可以被使用或增加以治疗局部的情况，例如心肌梗死，通常形成响应于大的透壁性心肌梗死的心室壁的明显的动脉瘤和二尖瓣反流 到不合规的二尖瓣。 这些技术也可用于治疗可能尚未进展为心肌病的局部病症。
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公开(公告)号：US09782258B2
公开(公告)日：2017-10-10
申请号：US11900005
申请日：2007-09-07
申请人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
发明人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
CPC分类号： A61F2/2451 , A61F2/2481 , A61F2002/249 , A61F2250/0067 , A61K9/0024 , A61L27/20 , A61L27/3873 , A61L27/52 , A61L2400/06 , A61M5/14 , A61M5/178 , A61M37/00 , A61M37/0069
摘要： Cardiomyopathy may be treated by distributing space-occupying agent within the myocardium in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress and stabilize or even reduce chamber size. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Over time the relief of wall stress reduces oxygen consumption and promotes healing. Moreover, various long-term therapeutic effects may be realized depending on the properties of the space-occupying agent, including combinations with other therapeutic materials. Specific cardiac conditions treatable by these systems and methods include, for example, dilated cardiomyopathy (with or without overt aneurismal formations), congestive heart failure, and ventricular arrhythmias. Patterns of distribution of space-occupying agent within the myocardium for global resizing may also be used or augmented to treat localized conditions such as myocardial infarctions, overt aneurysm of the ventricular wall as typically forms in response to large transmural myocardial infarctions, and mitral regurgitation due to a noncompliant mitral valve. These techniques may also be used to treat localized conditions that may not yet have progressed to cardiomyopathy.
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5.发明申请公开(公告)号：US20160338831A1
公开(公告)日：2016-11-24
申请号：US15161255
申请日：2016-05-22
申请人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
发明人： Hani N Sabbah , Randall J. Lee , Andrew G. Hinson
CPC分类号： A61F2/2451 , A61F2/2481 , A61F2002/249 , A61F2250/0067 , A61K9/0024 , A61L27/20 , A61L27/3873 , A61L27/52 , A61L2400/06 , A61M5/14 , A61M5/178 , A61M37/00 , A61M37/0069
摘要： Cardiomyopathy may be treated by distributing space-occupying agent within the myocardium in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress and stabilize or even reduce chamber size. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Over time the relief of wall stress reduces oxygen consumption and promotes healing. Moreover, various long-term therapeutic effects may be realized depending on the properties of the space-occupying agent, including combinations with other therapeutic materials. Specific cardiac conditions treatable by these systems and methods include, for example, dilated cardiomyopathy (with or without overt aneurismal formations), congestive heart failure, and ventricular arrhythmias. Patterns of distribution of space-occupying agent within the myocardium for global resizing may also be used or augmented to treat localized conditions such as myocardial infarctions, overt aneurysm of the ventricular wall as typically forms in response to large transmural myocardial infarctions, and mitral regurgitation due to a noncompliant mitral valve. These techniques may also be used to treat localized conditions that may not yet have progressed to cardiomyopathy.
摘要翻译： 心肌病可以通过以围绕心脏的一个或多个腔室的模式在心肌内分布空间占位剂来治疗，使得空间改变剂整合到腔室周围的至少部分心脏壁并使其增厚， 降低壁面应力，稳定或甚至减小腔室尺寸。 一些模式也引起了对室的有益的全局整形。 这些变化迅速发生并且是可持续的，并且对心脏功能具有快速和可持续的治疗作用。 随着时间的推移，墙壁压力的减轻会降低氧气消耗并促进愈合。 此外，根据空间占据剂的特性，包括与其它治疗材料的组合，可以实现各种长期治疗效果。 可通过这些系统和方法治疗的特异性心脏病症包括例如扩张型心肌病（有或没有明显的动脉瘤形成），充血性心力衰竭和室性心律失常。 用于全局调整大小的心肌内的空间占位剂的分布模式也可以被使用或增加以治疗局部的情况，例如心肌梗死，通常形成响应于大的透壁性心肌梗死的心室壁的明显的动脉瘤和二尖瓣反流 到不合规的二尖瓣。 这些技术也可用于治疗可能尚未进展为心肌病的局部病症。
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