公开(公告)号：US06123902A

公开(公告)日：2000-09-26

申请号：US147093

申请日：1998-10-07

申请人： Hans Koch ,  Hartmut Matz ,  Roman Kotitz ,  Dietmar Drung ,  Lutz Trahms ,  Werner Weitschies ,  Wolfhard Semmler

发明人： Hans Koch ,  Hartmut Matz ,  Roman Kotitz ,  Dietmar Drung ,  Lutz Trahms ,  Werner Weitschies ,  Wolfhard Semmler

IPC分类号： G01N33/553 ,  G01N27/72 ,  G01N33/483 ,  G01N33/487 ,  G01N33/543 ,  G01N35/00 ,  G01N25/20 ,  A01N1/02 ,  C12M1/00 ,  G01N21/00 ,  G01R33/02

CPC分类号： G01N33/54333 ,  G01N35/0098 ,  Y10S505/846

摘要： An apparatus for the qualitative and/or quantitative measurement of analytes, in particular in biological samples by means of receptor ligand binding and having a magnetizing device for the production of a magnetic field at the location of the sample and with a detection device for measurement of magnetic properties of the sample is characterized in that the magnetizing device is spatially disposed with respect to the detection device in such a fashion that the magnetic field produced by the magnetization device at the location of the magnetization is attenuated by at least a factor of 10, and preferentially by a factor of 1000 or more, at the location occupied by the sample during the measurement, or in that a switching device is provided for which, throughout a predetermined time duration and in particular during the measurement phase of the detection device can switch-off the magnetic field of the magnetizing device at the location of the sample. In this fashion new types of measurements for magnetorelaxometric detection of analytes or for the detection of analytes by means of remanence measurements can be carried out in a routine and economical fashion in vitro or in vivo.

摘要翻译： PCT No.PCT / DE97 / 00611 Sec。 371日期：1998年10月7日 102（e）日期1998年10月7日PCT 1997年3月26日PCT公布。 第WO97 / 40377号公报 日期1997年10月30日一种用于通过受体配体结合定性和/或定量测量分析物，特别是在生物样品中并具有用于在样品位置产生磁场的磁化装置和 用于测量样品的磁特性的检测装置的特征在于，磁化装置相对于检测装置以空间方式设置，使得磁化装置在磁化位置产生的磁场至少减弱 10倍的因子，优选为1000以上，在测量期间由样品占据的位置，或者提供了一种开关装置，其在整个预定的持续时间内，特别是在测量阶段期间 检测装置可以在样品的位置处关闭磁化装置的磁场。 在这种情况下，可以以常规和经济方式在体外或体内进行新型分析物的磁致谱测定或通过残留测量检测分析物的测量。