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公开(公告)号:US08034338B2
公开(公告)日:2011-10-11
申请号:US10552324
申请日:2004-04-16
CPC分类号: C07K16/42 , A61K2039/505 , C07K2317/52 , C07K2319/00
摘要: The invention refers to an immunogenic recombinant antibody designed for immunization of primates comprising at least a part of a murine IgG2a subtype amino acid sequence and a mammalian glycosylation.
摘要翻译: 本发明涉及设计用于免疫含有至少一部分鼠IgG2a亚型氨基酸序列和哺乳动物糖基化的灵长类动物的免疫原性重组抗体。
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公开(公告)号:US20110020331A1
公开(公告)日:2011-01-27
申请号:US12786378
申请日:2010-05-24
申请人: Manfred Schuster , Gottfried Himmler , Günter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
发明人: Manfred Schuster , Gottfried Himmler , Günter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
IPC分类号: A61K39/395 , C07K16/00 , A61P35/00
CPC分类号: C07K16/34 , C07K16/30 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要: The invention relates to a monoclonal antibody or derivative or fragment thereof that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region or region equivalent to the Fc region of said antibody or derivative or fragment thereof carries a bi-sected hybrid type N-glycosylation pattern and that said antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
摘要翻译: 本发明涉及衍生自亲本单克隆抗体的识别Lewis Y抗原的单克隆抗体或其衍生物或其片段,其特征在于与所述抗体或其衍生物或片段的Fc区相当的Fc区或区携带 双重杂交型N-糖基化模式,并且所述抗体显示出至少10倍的ADCC增加和至少10%的CDC活性降低。
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