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公开(公告)号：US09051577B2
公开(公告)日：2015-06-09
申请号：US12373268
申请日：2007-07-11
CPC分类号： C07K16/283 , C07K16/00 , C07K2317/14 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C12N15/8258
摘要： The present invention relates to an antibody preparation comprising modified antibodies of an animal or derivatives or fragments thereof, specific for an antigen, characterized in that • the antibodies or derivatives or fragments thereof comprise an N-glycan structure free of fucose and xylose, and • at least 90%, preferably at least 95%, more preferred at least 99%, most preferred at least 100% of the modified antibodies, derivatives or fragments thereof lack a C-terminal lysine residue.
摘要翻译： 本发明涉及包含对抗原特异性的动物或其衍生物或其片段的修饰抗体的抗体制剂，其特征在于：抗体或其衍生物或片段包含不含岩藻糖和木糖的N-聚糖结构，和 至少90％，优选至少95％，更优选至少99％，最优选至少100％的修饰抗体，其衍生物或片段缺少C-末端赖氨酸残基。
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公开(公告)号：US20150139942A1
公开(公告)日：2015-05-21
申请号：US14409161
申请日：2012-07-31
申请人： Hans Loibner , Manfred Schuster , Evelyne Janzek-Hawlat , Susanne Wiederkum , Bernhard Peball , Stefan Stranner , Oliver Mutschlechner , Franz Groiss , Ruth Ladenstein , Holger Lode
发明人： Hans Loibner , Manfred Schuster , Evelyne Janzek-Hawlat , Susanne Wiederkum , Bernhard Peball , Stefan Stranner , Oliver Mutschlechner , Franz Groiss , Ruth Ladenstein , Holger Lode
IPC分类号： C07K16/30 , A61K31/485 , A61K39/395 , A61K45/06
CPC分类号： C07K16/3084 , A61K31/485 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/24 , C07K2317/734 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to a method for treating a GD2 positive cancer by administering a preparation comprising an anti-GD2 antibody to a patient as a continuous intravenous infusion over 24 hours per day.
摘要翻译： 本发明涉及一种治疗GD2阳性癌症的方法，其通过以每天24小时连续静脉内输注给患者施用包含抗GD2抗体的制剂。
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公开(公告)号：US08034338B2
公开(公告)日：2011-10-11
申请号：US10552324
申请日：2004-04-16
CPC分类号： C07K16/42 , A61K2039/505 , C07K2317/52 , C07K2319/00
摘要： The invention refers to an immunogenic recombinant antibody designed for immunization of primates comprising at least a part of a murine IgG2a subtype amino acid sequence and a mammalian glycosylation.
摘要翻译： 本发明涉及设计用于免疫含有至少一部分鼠IgG2a亚型氨基酸序列和哺乳动物糖基化的灵长类动物的免疫原性重组抗体。
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公开(公告)号：US20110020315A1
公开(公告)日：2011-01-27
申请号：US12808818
申请日：2008-12-18
申请人： Hans Loibner , Manfred Schuster
发明人： Hans Loibner , Manfred Schuster
CPC分类号： A61K38/4813
摘要： The present invention relates to ACE2 for the therapeutic treatment or prevention of inflammation.
摘要翻译： 本发明涉及用于治疗或预防炎症的ACE2。
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5.发明授权Focus detector arrangement and method for generating contrast x-ray images 有权用于产生对比度X射线图像的聚焦探测器布置和方法公开(公告)号：US07817777B2
公开(公告)日：2010-10-19
申请号：US12159486
申请日：2006-12-06
申请人： Joachim Baumann , Christian David , Martin Engelhardt , Jörg Freudenberger , Eckhard Hempel , Martin Hoheisel , Thomas Mertelmeier , Franz Pfeiffer , Stefan Popescu , Manfred Schuster
发明人： Joachim Baumann , Christian David , Martin Engelhardt , Jörg Freudenberger , Eckhard Hempel , Martin Hoheisel , Thomas Mertelmeier , Franz Pfeiffer , Stefan Popescu , Manfred Schuster
IPC分类号： G01N23/04
CPC分类号： A61B6/00 , A61B6/032 , A61B6/4028 , A61B6/4291 , A61B6/4441 , A61B6/484 , G21K2201/06 , G21K2207/005 , H01J2235/086
摘要： In a focus detector arrangement and method for an x-ray apparatus for generating projection or tomographic phase-contrast images of an examination subject, a beam of coherent x-rays is generated by an anode that has areas of different radiation emission characteristics arranged in bands thereon, that proceed parallel to grid lines of a phase grid that is used to generate the phase-contrast images.
摘要翻译： 在用于产生检查对象的投影或断层相位图像的x射线装置的焦点检测器装置和方法中，由具有布置在带中的不同辐射特性的区域的阳极产生相干X射线束 其平行于用于生成相位对比图像的相位网格的网格线。
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6.发明授权Focus-detector arrangement for generating projective or tomographic phase contrast recordings with X-ray optical gratings 有权用于使用X射线光栅产生投影或断层相位对比记录的焦点检测器布置公开(公告)号：US07564941B2
公开(公告)日：2009-07-21
申请号：US11700154
申请日：2007-01-31
申请人： Joachim Baumann , Christian David , Martin Engelhardt , Jörg Freudenberger , Eckhard Hempel , Martin Hoheisel , Thomas Mertelmeier , Franz Pfeiffer , Stefan Popescu , Manfred Schuster
发明人： Joachim Baumann , Christian David , Martin Engelhardt , Jörg Freudenberger , Eckhard Hempel , Martin Hoheisel , Thomas Mertelmeier , Franz Pfeiffer , Stefan Popescu , Manfred Schuster
IPC分类号： A61B6/00
CPC分类号： G01N23/046 , A61B6/4092 , A61B6/4291 , A61B6/484 , G01N2223/419 , G01N2223/612 , G21K1/06 , G21K2207/005
摘要： A focus-detector arrangement of an X-ray apparatus is disclosed for generating projective or tomographic phase contrast recordings with a phase grating. According to at least one embodiment of the invention, in the gaps between its bars, the phase grating includes a filler material whose linear attenuation coefficient in the relevant energy range is greater than that of the bars. The height of the filler material in the gaps is dimensioned on the one hand so that the X-radiation with the energy used for measuring the phase shift generates a phase shift in the X-radiation such that, after the phase grating, the rays which pass through the bars are phase shifted by one half wavelength relative to the rays which pass through the gaps with the filler material. Further, the height of the filler material in the gaps on the other hand is dimensioned so that the attenuation of the X-radiation, at least in relation to the energy used for measuring the phase shift, is the same when passing through the bars and when passing through the filler material.
摘要翻译： 公开了一种用于利用相位光栅产生投射或断层相位对比度记录的X射线装置的聚焦检测器装置。 根据本发明的至少一个实施例，在其杆之间的间隙中，相位光栅包括其相关能量范围内的线性衰减系数大于棒的线性衰减系数的填充材料。 间隙中的填充材料的高度一方面确定尺寸，使得具有用于测量相移的能量的X射线在X辐射中产生相移，使得在相位光栅之后，射线 通过条相对于通过填充材料的间隙的光线相移一半波长。 此外，另一方面，间隙中的填充材料的高度的尺寸被设计成使得至少相对于用于测量相移的能量的X射线的衰减在通过杆时是相同的，并且 当通过填料时。
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7.发明授权Focus-detector arrangement with X-ray optical grating for phase contrast measurement 有权用于相位测量的X射线光栅的聚焦检测器布置公开(公告)号：US07453981B2
公开(公告)日：2008-11-18
申请号：US11700173
申请日：2007-01-31
申请人： Joachim Baumann , Martin Engelhardt , Jörg Freudenberger , Eckhard Hempel , Martin Hoheisel , Thomas Mertelmeier , Stefan Popescu , Manfred Schuster
发明人： Joachim Baumann , Martin Engelhardt , Jörg Freudenberger , Eckhard Hempel , Martin Hoheisel , Thomas Mertelmeier , Stefan Popescu , Manfred Schuster
IPC分类号： G01N23/04
CPC分类号： G21K1/06 , A61B6/4092 , A61B6/4291 , A61B6/484 , G21K2207/005
摘要： A focus-detector arrangement of an X-ray apparatus is disclosed, for generating projective or tomographic phase contrast recordings of a subject. In at least one embodiment, least one grating of a focus-detector arrangement includes, at least partially, a macroscopically homogeneous medium which, when excited by an energy source, assumes a periodic structure/standing wave field that leads to beam splitting and the formation of an interference pattern when the X-ray beam passes through.
摘要翻译： 公开了一种用于产生对象的投影或断层相位对比记录的X射线装置的聚焦检测器装置。 在至少一个实施例中，聚焦检测器装置的至少一个光栅至少部分地包括宏观均匀的介质，当被能量源激发时，它们呈现导致光束分裂和形成的周期性结构/驻波场 的X射线束通过时的干涉图案。
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8.发明授权Focus-detector arrangement of an X-ray apparatus for generating projective or tomographic phase contrast recordings 有权用于产生投影或断层相位对比记录的X射线设备的焦点检测器布置公开(公告)号：US07433444B2
公开(公告)日：2008-10-07
申请号：US11700060
申请日：2007-01-31
申请人： Joachim Baumann , Christian David , Martin Engelhardt , Jörg Freudenberger , Eckhard Hempel , Martin Hoheisel , Thomas Mertelmeier , Franz Pfeiffer , Stefan Popescu , Manfred Schuster
发明人： Joachim Baumann , Christian David , Martin Engelhardt , Jörg Freudenberger , Eckhard Hempel , Martin Hoheisel , Thomas Mertelmeier , Franz Pfeiffer , Stefan Popescu , Manfred Schuster
IPC分类号： G21K1/00
CPC分类号： A61B6/032 , A61B6/06 , A61B6/4021 , A61B6/4092 , A61B6/4291 , A61B6/484 , A61B6/508 , G21K2207/005
摘要： A focus-detector arrangement of an X-ray apparatus is disclosed for generating projective or tomographic phase contrast recordings of an observed region of a subject. In at least one embodiment, the arrangement includes a radiation source which emits a coherent or quasi-coherent X-radiation and irradiates the subject, a phase grating which is arranged behind the subject in the beam path of the radiation source and generates an interference pattern of the X-radiation in a predetermined energy range, and an analysis-detector system which detects at least the interference pattern generated by the phase grating in respect of its phase shift with position resolution. Further, the beam path of the X-radiation used diverges in at least one plane between the focus and the detector.
摘要翻译： 公开了用于产生被摄体的观察区域的投影或层析相位对比记录的X射线装置的聚焦检测器装置。 在至少一个实施例中，该装置包括发射相干或准相干X射线并照射对象的辐射源，布置在辐射源的光束路径中的被摄体后面的相位光栅，并产生干涉图案 的X射线在预定能量范围内的分析检测器系统，以及分析检测器系统，其至少检测相位光栅相对于其相移与位置分辨率产生的干涉图案。 此外，所使用的X辐射的光束路径在焦点和检测器之间的至少一个平面中发散。
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9.发明申请Method and measuring arrangement for nondestructive analysis of an examination object by means of x-radiation 有权通过x射线对检查对象进行非破坏性分析的方法和测量装置公开(公告)号：US20070189449A1
公开(公告)日：2007-08-16
申请号：US11700061
申请日：2007-01-31
申请人： Joachim Baumann , Martin Engelhardt , Jorg Freudenberger , Eckhard Hempel , Martin Hoheisel , Thomas Mertelmeier , Stefan Popescu , Manfred Schuster
发明人： Joachim Baumann , Martin Engelhardt , Jorg Freudenberger , Eckhard Hempel , Martin Hoheisel , Thomas Mertelmeier , Stefan Popescu , Manfred Schuster
IPC分类号： G01N23/223 , G01T1/36
CPC分类号： G01N23/20 , A61B6/4021 , A61B6/4092 , A61B6/482 , A61B6/484 , G01N23/22 , G21K2207/005
摘要： A method and a measuring arrangement are disclosed for nondestructive analysis of an examination object. In at least one embodiment of the method, x-radiation having a specific energy spectrum is generated by an x-ray source, with the aid of at least one x-ray/optical grating in the beam path of the x-radiation there is generated a standing wave field of this x-radiation that is positioned at least partially in the examination object, and the radiation excited by the x-ray standing wave field in the examination object is measured as a function of at least one relative position between the examination object and the x-ray standing wave field. Further, a material distribution in the examination object is inferred from the measurement result of the radiation excited by the x-ray standing wave field.
摘要翻译： 公开了用于检查对象的非破坏性分析的方法和测量装置。 在该方法的至少一个实施例中，具有特定能谱的x射线由x射线源产生，借助于X辐射的光束路径中的至少一个x射线/光栅， 产生至少部分地位于检查对象中的该X射线的驻波场，并且由检查对象中的x射线驻波场激发的辐射作为至少一个相对位置 检查对象和X射线驻波场。 此外，从X射线驻波激励的辐射的测量结果推断检查对象中的材料分布。
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10.发明申请Focus-detector arrangement for generating projective or tomographic phase contrast recordings with X-ray optical gratings 有权用于使用X射线光栅产生投影或断层相位对比记录的焦点检测器布置公开(公告)号：US20070183582A1
公开(公告)日：2007-08-09
申请号：US11700154
申请日：2007-01-31
申请人： Joachim Baumann , Christian David , Martin Engelhardt , Jorg Freudenberger , Eckhard Hempel , Martin Hoheisel , Thomas Mertelmeier , Franz Pfeiffer , Stefan Popescu , Manfred Schuster
发明人： Joachim Baumann , Christian David , Martin Engelhardt , Jorg Freudenberger , Eckhard Hempel , Martin Hoheisel , Thomas Mertelmeier , Franz Pfeiffer , Stefan Popescu , Manfred Schuster
IPC分类号： G21K1/00
CPC分类号： G01N23/046 , A61B6/4092 , A61B6/4291 , A61B6/484 , G01N2223/419 , G01N2223/612 , G21K1/06 , G21K2207/005
摘要： A focus-detector arrangement of an X-ray apparatus is disclosed for generating projective or tomographic phase contrast recordings with a phase grating. According to at least one embodiment of the invention, in the gaps between its bars, the phase grating includes a filler material whose linear attenuation coefficient in the relevant energy range is greater than that of the bars. The height of the filler material in the gaps is dimensioned on the one hand so that the X-radiation with the energy used for measuring the phase shift generates a phase shift in the X-radiation such that, after the phase grating, the rays which pass through the bars are phase shifted by one half wavelength relative to the rays which pass through the gaps with the filler material. Further, the height of the filler material in the gaps on the other hand is dimensioned so that the attenuation of the X-radiation, at least in relation to the energy used for measuring the phase shift, is the same when passing through the bars and when passing through the filler material.
摘要翻译： 公开了一种用于利用相位光栅产生投射或断层相位对比度记录的X射线装置的聚焦检测器装置。 根据本发明的至少一个实施例，在其杆之间的间隙中，相位光栅包括其相关能量范围内的线性衰减系数大于棒的线性衰减系数的填充材料。 间隙中的填充材料的高度一方面确定尺寸，使得具有用于测量相移的能量的X射线在X辐射中产生相移，使得在相位光栅之后，射线 通过条相对于通过填充材料的间隙的光线相移一半波长。 此外，另一方面，间隙中的填充材料的高度的尺寸被设计成使得至少相对于用于测量相移的能量的X射线的衰减在通过杆时是相同的，并且 当通过填料时。
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