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    Polysaccharide-polypeptide conjugate
    2.
    发明授权
    Polysaccharide-polypeptide conjugate 有权
    多糖 - 多肽缀合物

    公开(公告)号：US08153135B2

    公开(公告)日：2012-04-10

    申请号：US11223993

    申请日：2005-09-13

    申请人： Hans Loibner ,  Helmut Eckert

    发明人： Hans Loibner ,  Helmut Eckert

    IPC分类号： A61K39/395 ,  C07K16/46

    CPC分类号： A61K47/6851 ,  A61K47/61 ,  A61K47/646

    摘要： Disclosed is a method of producing a polysaccharide-polypeptide conjugate by reacting a polysaccharide with a polypeptide which contains at least one free amino group, wherein a polysaccharide carrier comprising vicinal hydroxyl groups is oxidized under ring opening to create vicinal aldehyde groups and is reacted with one or more base-instable antigenic polypeptide(s) containing at least one free amino group, the polypeptide(s) being bound directly to the polysaccharide carrier via at least one azomethine bond.

    摘要翻译： 公开了通过使多糖与含有至少一个游离氨基的多肽反应制备多糖 - 多肽缀合物的方法，其中包含连位羟基的多糖载体在开环下被氧化以产生连位醛基并与一个 或多个含有至少一个游离氨基的碱基不稳定抗原多肽，所述多肽通过至少一个偶氮甲碱键直接结合至多糖载体。

    USE OF A PREPARATION BASED ON AN ANTIBODY DIRECTED AGAINST A TUMOR-ASSOCIATED GLYCOSYLATION
    3.
    发明申请
    USE OF A PREPARATION BASED ON AN ANTIBODY DIRECTED AGAINST A TUMOR-ASSOCIATED GLYCOSYLATION 审中-公开
    基于针对肿瘤相关糖蛋白的抗体的制备的使用

    公开(公告)号：US20090181030A1

    公开(公告)日：2009-07-16

    申请号：US12391226

    申请日：2009-02-23

    申请人： Hans LOIBNER ,  Gottfried Himmler ,  Thomas Putz ,  Michael Freissmuth ,  Markus Klinger ,  Hesso Farhan

    发明人： Hans LOIBNER ,  Gottfried Himmler ,  Thomas Putz ,  Michael Freissmuth ,  Markus Klinger ,  Hesso Farhan

    IPC分类号： A61K39/395 ,  A61P35/00

    CPC分类号： C07K16/30 ,  A61K39/395 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/77 ,  A61K2300/00

    摘要： The invention relates to the use of a preparation based on an antibody directed against a tumor-associated glycosylation for preparing a medicament for the prophylactic and/or therapeutic treatment for the reduction or inhibition, respectively, of the growth of tumor cells in a cancer patient, as well as to a pharmaceutical preparation containing an antibody directed against a tumor-associated glycosylation. Moreover, the invention relates to a preparation for pharmaceutical and/or diagnostic use, a diagnostic method and an agent for determining the risk of metastasis formation in a cancer patient, as well as a method of producing a preparation based on a body fluid or tissue, in each case using the antibody directed against a tumor-associated glycosylation.

    摘要翻译： 本发明涉及基于针对肿瘤相关糖基化的抗体的制剂的制备用于制备用于预防和/或治疗治疗癌症患者中肿瘤细胞生长的减少或抑制的药物的用途 ，以及含有针对肿瘤相关糖基化的抗体的药物制剂。 此外，本发明涉及用于药物和/或诊断用途的制剂，用于确定癌症患者转移形成风险的诊断方法和试剂，以及基于体液或组织制备制剂的方法 在每种情况下使用针对肿瘤相关糖基化的抗体。

    Immunotherapy of rectal cancer
    6.
    发明申请
    Immunotherapy of rectal cancer 审中-公开
    直肠癌免疫治疗

    公开(公告)号：US20060246056A1

    公开(公告)日：2006-11-02

    申请号：US10558166

    申请日：2004-05-24

    申请人： Hans Loibner ,  Helmut Eckert ,  Gottfried Himmler

    发明人： Hans Loibner ,  Helmut Eckert ,  Gottfried Himmler

    IPC分类号： A61K39/395

    CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/3046

    摘要： Described is the use of an immunotherapeutic agent targeting a human tumor associated antigen for the production of a medicament for immunotherapy of patients with rectal cancer or being at risk of rectal cancer, wherein the immunotherapeutic agent is a vaccine, an antibody or derivative or fragment thereof.

    摘要翻译： 描述了靶向人肿瘤相关抗原的免疫治疗剂用于生产用于直肠癌患者或直肠癌风险的免疫治疗药物的用途，其中所述免疫治疗剂是疫苗，抗体或其衍生物或片段 。