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    Salt Forms of 4- (4-Methylpiperazin-1-Ylmethyl) -N- [4-Methyl-3- (4-Pyridin-3-Yl) Pyrimidin-2-Ylamino) Phenyl]- Benzamide
    1.
    发明申请
    Salt Forms of 4- (4-Methylpiperazin-1-Ylmethyl) -N- [4-Methyl-3- (4-Pyridin-3-Yl) Pyrimidin-2-Ylamino) Phenyl]- Benzamide 审中-公开
    盐形式的4-（4-甲基哌嗪-1-基甲基）-N- [4-甲基-3-（4-吡啶-3-基）嘧啶-2-基]氨基）苯基] - 苯甲酰胺

    公开(公告)号：US20080249104A1

    公开(公告)日：2008-10-09

    申请号：US10597287

    申请日：2005-02-03

    申请人： Hans Michael Burger ,  Paul William Manley ,  Michael Mutz

    发明人： Hans Michael Burger ,  Paul William Manley ,  Michael Mutz

    IPC分类号： A61K31/506 ,  C07D401/14 ,  A61P35/04

    CPC分类号： C07D401/04

    摘要： The present invention relates to acid addition salts of 4-[(4-methyl-1-piperazinyl)methyl]-N-(4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide, which are selected from the group consisting of a tartrate salt, such as a (D)(−) tartrate salt or a (L)(+) tartrate salt, a hydrochloride salt, a citrate salt, a malate salt, a fumarate salt, a succinate salt, a benzoate salt, a benzenesulfonate salt, a pamoate salt, a formate salt, a malonate salt, a 1,5-naphthalenedisulfonate salt, a salicylate salt, a cyclohexanesulfamate salt, a lactate salt, a mandelate salt, aq glutarate salt, an adipate salt, a squarate salt, a vanillate salt, an oxaloacetate salt, an ascorbate salt and a sulfate salt.

    摘要翻译： 本发明涉及4 - [（4-甲基-1-哌嗪基）甲基] -N-（4-甲基-3 - [[4-（3-吡啶基）-2-嘧啶基]氨基]苯基的酸加成盐 （D）（ - ）酒石酸盐或（L）（+）酒石酸盐，盐酸盐，柠檬酸盐，苹果酸盐等的酒石酸盐， 富马酸盐，琥珀酸盐，苯甲酸盐，苯磺酸盐，双羟萘酸盐，甲酸盐，丙二酸盐，1,5-萘二磺酸盐，水杨酸盐，环己烷氨基磺酸盐，乳酸盐，扁桃酸盐 盐，戊二酸水杨酸盐，己二酸盐，方酸盐，香草酸盐，草酰乙酸盐，抗坏血酸盐和硫酸盐。