公开(公告)号：US20110091447A1

公开(公告)日：2011-04-21

申请号：US12922227

申请日：2009-03-13

申请人： Hans-Michael Dosch ,  Yin Chan ,  Shawn Winer ,  Geoffrey Palster

发明人： Hans-Michael Dosch ,  Yin Chan ,  Shawn Winer ,  Geoffrey Palster

IPC分类号： A61K39/395 ,  A61P3/00 ,  A61P3/10

CPC分类号： A61K38/2093 ,  C07K16/244 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/76 ,  A61K2300/00

摘要： Methods for the treatment, inhibition, prevention, etc. of metabolic syndrome (MetSyn) and/or Type-2 diabetes (T2D) using a T cell activating antibody that stimulates activation and immunomodulation of T-cells to affect the immune environment of adipose tissue and improve insulin sensitivity. Also methods for the treatment, inhibition, prevention, amelioration, reversal, etc., of metabolic syndrome (MetSyn) and/or Type-2 diabetes (T2D) using leukemia inhibitory factor (LIF), or a functional portion thereof. Compositions administered to individuals having or at risk of developing MetSyn and/or T2D may include pharmaceutical compositions. Methods may also provide tolerogenic vaccines based on the administration of identified auto-antigens from individuals having or at risk of developing MetSyn and/or T2D.

摘要翻译： 使用刺激T细胞的活化和免疫调节以影响脂肪组织的免疫环境的T细胞活化抗体来治疗，抑制，预防代谢综合征（MetSyn）和/或2型糖尿病（T2D）的方法 并提高胰岛素敏感性。 还有使用白血病抑制因子（LIF）或其功能部分的代谢综合征（MetSyn）和/或2型糖尿病（T2D）的治疗，抑制，预防，改善，逆转等的方法。 对具有或有开发MetSyn和/或T2D风险的个体施用的组合物可包括药物组合物。 方法还可以提供基于从具有或有开发MetSyn和/或T2D风险的个体给予鉴定的自身抗原的耐受性疫苗。

公开(公告)号：US20090221511A1

公开(公告)日：2009-09-03

申请号：US12394261

申请日：2009-02-27

申请人： Hans-Michael DOSCH ,  Lan Tang ,  Yin Chan ,  Michael Salter

发明人： Hans-Michael DOSCH ,  Lan Tang ,  Yin Chan ,  Michael Salter

IPC分类号： A61K38/08 ,  A61K31/165 ,  A61P3/10

CPC分类号： A61K38/046 ,  Y10S514/866

摘要： A process is disclosed for controlling inflammatory tissue access through release of neuropeptides, such as substance P (sP), to insulin-responsive sensory neurons, whereby simultaneous control of insulin sensitivity/resistance is manifested. In models of Type 1 and Type 2 diabetes, sensory afferents, in particular TRPV1, have fundamental roles in insulin/glucose homeostasis, islet physiology and autoimmune tissue inflammation. By manipulation of the TRPV1 neuro-β-cell circuit or enhancement of pancreatic sP levels, normalization of insulin resistance, clearance of inflammation and prevention of both Type 1 and Type 2 diabetes is realized.

摘要翻译： 公开了一种通过将神经肽（例如物质P（sP））释放到胰岛素反应性感觉神经元来控制炎症组织进入的方法，由此表现出胰岛素敏感性/抗性的同时控制。 在1型和2型糖尿病模型中，感觉传入特别是TRPV1在胰岛素/葡萄糖体内平衡，胰岛生理和自身免疫组织炎症中具有重要作用。 通过操纵TRPV1神经 - β细胞电路或增强胰腺sP水平，实现胰岛素抵抗的正常化，炎症清除和预防1型和2型糖尿病。

公开(公告)号：US07544365B2

公开(公告)日：2009-06-09

申请号：US11638830

申请日：2006-12-14

申请人： Hans-Michael Dosch ,  Lan Tang ,  Yin Chan ,  Michael Salter

发明人： Hans-Michael Dosch ,  Lan Tang ,  Yin Chan ,  Michael Salter

IPC分类号： A61K45/00 ,  A61K39/00 ,  C07K5/00 ,  C07K14/00

CPC分类号： A61K38/046 ,  Y10S514/866

摘要： A process is disclosed for controlling inflammatory tissue access through release of neuropeptides, such as substance P (sP), to insulin-responsive sensory neurons, whereby simultaneous control of insulin sensitivity/resistance is manifested. In models of Type 1 and Type 2 diabetes, sensory afferents, in particular TRPV1, have fundamental roles in insulin/glucose homeostasis, islet physiology and autoimmune tissue inflammation. By manipulation of the TRPV1 neuro-β-cell circuit or enhancement of pancreatic sP levels, normalization of insulin resistance, clearance of inflammation and prevention of both Type 1 and Type 2 diabetes is realized.

摘要翻译： 公开了一种通过将神经肽（例如物质P（sP））释放到胰岛素反应性感觉神经元来控制炎症组织进入的方法，由此表现出胰岛素敏感性/抗性的同时控制。 在1型和2型糖尿病模型中，感觉传入特别是TRPV1在胰岛素/葡萄糖体内平衡，胰岛生理和自身免疫组织炎症中具有重要作用。 通过操纵TRPV1神经 - β细胞电路或增强胰腺sP水平，实现胰岛素抵抗的正常化，炎症清除和预防1型和2型糖尿病。

公开(公告)号：US20090312255A1

公开(公告)日：2009-12-17

申请号：US12478898

申请日：2009-06-05

申请人： Hans-Michael DOSCH ,  Lan Tang ,  Yin Chan ,  Michael Salter

发明人： Hans-Michael DOSCH ,  Lan Tang ,  Yin Chan ,  Michael Salter

IPC分类号： A61K31/165 ,  A61P3/10 ,  A61K38/17

CPC分类号： A61K38/046 ,  A61K31/165

摘要： The present invention provides a method of altering the function of TRPV1+ sensory afferent neurons in the pancreas as a way of treating, managing, alleviating, etc., the symptoms and/or underlying causes of diabetes or abnormal glucose metabolism by increasing the release of neuropeptides, such as substance P (sP) or other tachykinin peptide, in the pancreas. This may be achieved by injecting a TRPV1 agonist, such as a capsaicinoid compound or capsaicin analog, or a neuropeptide, such as sP or other tachykinin peptide, directly into the pancreas, or alternatively, by stimulating one or more intercostal and/or subcostal nerves of spinal nerves derived from one or more thoracic segments T8 through T12 by chemical, electrical, surgical, mechanical, etc., methods.

摘要翻译： 本发明提供了一种通过增加神经肽的释放来改变胰腺中TRPV1 +感觉传入神经元的功能的方法，作为治疗，控制，缓解等症状和/或糖尿病异常或糖代谢异常的原因的方法 ，例如胰岛中的物质P（sP）或其他速激肽肽。 这可以通过将TRPV1激动剂如辣椒素化合物或辣椒素类似物或神经肽如sP或其它速激肽肽直接注射到胰腺中，或者通过刺激一种或多种肋间和/或肋下神经来实现 通过化学，电气，手术，机械等方法从一个或多个胸段T8至T12衍生的脊神经。

公开(公告)号：US20080145386A1

公开(公告)日：2008-06-19

申请号：US11638830

申请日：2006-12-14

申请人： Hans-Michael Dosch ,  Lan Tang ,  Yin Chan ,  Michael Salter

发明人： Hans-Michael Dosch ,  Lan Tang ,  Yin Chan ,  Michael Salter

IPC分类号： A61K38/17 ,  A61K31/00

CPC分类号： A61K38/046 ,  Y10S514/866

摘要： A process is disclosed for controlling inflammatory tissue access through release of neuropeptides, such as substance P (sP), to insulin-responsive sensory neurons, whereby simultaneous control of insulin sensitivity/resistance is manifested. In models of Type 1 and Type 2 diabetes, sensory afferents, in particular TRPV1, have fundamental roles in insulin/glucose homeostasis, islet physiology and autoimmune tissue inflammation. By manipulation of the TRPV1 neuro-β-cell circuit or enhancement of pancreatic sP levels, normalization of insulin resistance, clearance of inflammation and prevention of both Type 1 and Type 2 diabetes is realized.

摘要翻译： 公开了一种通过将神经肽（例如物质P（sP））释放到胰岛素反应性感觉神经元来控制炎症组织进入的方法，由此表现出胰岛素敏感性/抗性的同时控制。 在1型和2型糖尿病模型中，感觉传入特别是TRPV1在胰岛素/葡萄糖体内平衡，胰岛生理和自身免疫组织炎症中具有重要作用。 通过操纵TRPV1神经 - β细胞电路或增强胰腺sP水平，实现胰岛素抵抗的正常化，炎症清除和预防1型和2型糖尿病。

公开(公告)号：US20060114960A1

公开(公告)日：2006-06-01

申请号：US11288321

申请日：2005-11-29

申请人： Preston Snee ,  Yin Chan ,  Daniel Nocera ,  Moungi Bawendi

发明人： Preston Snee ,  Yin Chan ,  Daniel Nocera ,  Moungi Bawendi

IPC分类号： H01S3/07 ,  H01S3/083

CPC分类号： H01S3/0627 ,  B82Y20/00 ,  G02F2202/36 ,  H01S3/0604 ,  H01S5/10 ,  H01S5/1042 ,  H01S5/1075

摘要： An optical resonator can include an optical feedback structure disposed on a substrate, and a composite including a matrix including a chromophore. The composite disposed on the substrate and in optical communication with the optical feedback structure. The chromophore can be a semiconductor nanocrystal. The resonator can provide laser emission when excited.

摘要翻译： 光学谐振器可以包括设置在基板上的光学反馈结构和包括发色团的矩阵的复合物。 复合材料设置在基板上并与光学反馈结构光学通信。 发色团可以是半导体纳米晶体。 谐振器在激发时可以提供激光发射。