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公开(公告)号：US20060003921A1
公开(公告)日：2006-01-05
申请号：US11218406
申请日：2005-09-02
IPC分类号： A61K38/37
CPC分类号： A61K38/37
摘要： Described is a pharmaceutical preparation for treating blood coagulation disorders comprising an effective amount of vWF propeptide as well as a method for producing such a preparation.
摘要翻译： 描述了一种用于治疗凝血障碍的药物制剂，其包含有效量的vWF前肽以及制备这种制剂的方法。
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2.发明申请Diagnostic test for determining the concentration of transient proteolytic activity in composite biological media 有权用于确定复合生物培养基中瞬时蛋白水解活性浓度的诊断试验公开(公告)号：US20060051828A1
公开(公告)日：2006-03-09
申请号：US10514269
申请日：2003-05-01
摘要： A method is provided for determining in real time the course of thrombin activity in a sample of blood or plasma as it appears in and disappears from the simple which comprises adding a thrombin substrate to the sample that, per unit time, produces a detectable signal in a quantity that bears relation to the amount of thrombin present. Simultaneously, in a control sample of the same blood or plasma in which thrombin generation is not triggered, the activity of a standard preparation with invariable thrombin activity is measured. The exact molar amount of thrombin present at any moment is obtained by comparison of the activity measured in clotting blood and the simultaneously measured calibrator. The method is useful inter alia for diagnosing hyper- and hypo-coaguable states, either congenital, acquired or drug-induced in humans and animals. Also provided is a kit for use in this method.
摘要翻译： 提供了一种方法，用于实时测定血液或血浆样品中凝血酶活性的过程，因为其在简单中出现并消失，其包括向样品中加入凝血酶底物，每单位时间产生可检测的信号 与存在凝血酶量有关的数量。 同时，在没有引发凝血酶生成的相同血液或血浆的对照样品中，测定具有不变凝血酶活性的标准制剂的活性。 通过比较在凝血血液和同时测量的校准物中测量的活性，可以获得随时存在的凝血酶的确切摩尔量。 该方法尤其用于诊断在人和动物中先天性，获得性或药物诱导的超和不可凝结状态。 还提供了用于该方法的试剂盒。
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公开(公告)号：US20090311730A1
公开(公告)日：2009-12-17
申请号：US11919431
申请日：2006-04-26
申请人： Hendrik Coenraad Hemker , Suzette Beguin , Raed Al-Dieri , Robert Wagenvoord , Sebastiaan Nijhuis , Peter Giesen
发明人： Hendrik Coenraad Hemker , Suzette Beguin , Raed Al-Dieri , Robert Wagenvoord , Sebastiaan Nijhuis , Peter Giesen
IPC分类号： C12Q1/56
CPC分类号： C12Q1/56 , G01N2333/974
摘要： The invention relates to a method for in vitro determining thrombin activity in a sample wherein the sample is a blood sample and thrombin generation is measured by the steps of: —contacting a layer of said sample with a fluorogenic substrate of thrombin, wherein said layer has a thickness within a range of 0.05 to 5 mm and a surface within a range of 10 to 500 mm2; —allowing thrombin to generate in said sample; —measuring the fluorescence emitted from the surface of the layer, by the fluorescent group released from the fluorogenic substrate as a result of enzymatic action of generated thrombin on said fluorogenic substrate.
摘要翻译： 本发明涉及一种用于体外测定样品中凝血酶活性的方法，其中样品是血液样品，并且通过以下步骤测量凝血酶产生： - 用凝血酶的荧光底物接触所述样品层，其中所述层具有 厚度在0.05〜5mm的范围内，表面在10〜500mm 2的范围内; - 使凝血酶在所述样品中产生; - 通过荧光基质释放的荧光基团测定从该表面发射的荧光，这是由于在所述荧光底物上产生的凝血酶的酶作用的结果。
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公开(公告)号：US08916356B2
公开(公告)日：2014-12-23
申请号：US11919431
申请日：2006-04-26
申请人： Hendrik Coenraad Hemker , Suzette Beguin , Raed Al-Dieri , Robert Wagenvoord , Sebastiaan Nijhuis , Peter Giesen
发明人： Hendrik Coenraad Hemker , Suzette Beguin , Raed Al-Dieri , Robert Wagenvoord , Sebastiaan Nijhuis , Peter Giesen
IPC分类号： C12Q1/56
CPC分类号： C12Q1/56 , G01N2333/974
摘要： The invention relates to a method for in vitro determining thrombin activity in a sample wherein the sample is a blood sample and thrombin generation is measured by the steps of: —contacting a layer of said sample with a fluorogenic substrate of thrombin, wherein said layer has a thickness within a range of 0.05 to 5 mm and a surface within a range of 10 to 500 mm2; —allowing thrombin to generate in said sample; —measuring the fluorescence emitted from the surface of the layer, by the fluorescent group released from the fluorogenic substrate as a result of enzymatic action of generated thrombin on said fluorogenic substrate.
摘要翻译： 本发明涉及一种用于体外测定样品中凝血酶活性的方法，其中样品是血液样品，并且通过以下步骤测量凝血酶产生： - 用凝血酶的荧光底物接触所述样品层，其中所述层具有 厚度在0.05〜5mm的范围内，表面在10〜500mm 2的范围内; - 使凝血酶在所述样品中产生; - 通过荧光基质释放的荧光基团测定从该表面发射的荧光，这是由于在所述荧光底物上产生的凝血酶的酶作用的结果。
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