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公开(公告)号：US20120196789A1
公开(公告)日：2012-08-02
申请号：US13500040
申请日：2010-10-05
申请人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, JR.
发明人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, JR.
IPC分类号： A61K38/06 , A61P9/12 , A61P25/28 , A61P35/00 , A61P9/10 , A61P11/06 , A61P9/04 , A61P17/06 , A61P11/00 , A61P29/00 , A61P19/02 , A61P1/00 , A61P43/00 , A61P9/00 , A61P37/06 , A61P31/00 , A61P37/08 , A61P21/00 , A61P7/00 , A61P25/16 , C07K4/00 , C07K5/09 , A61P25/00
摘要： The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.
摘要翻译： 本发明提供具有式AA1-AA2-AA3的肽类过氧化物酶抑制剂，其中AA1为带正电荷的带负电荷或中性氨基酸，AA2为氧化还原活性氨基酸，AA3为具有还原电位的氨基酸 使得AA3能够与氨基酸AA2的基团或其逆反相或类似物进行氧化还原反应。 这种组合的结果是高度有效的过氧化物酶活性抑制剂，其在广泛多样化的血管疾病和损伤模型中具有有效的抗炎特性。 示例性三肽有效抑制过氧化物酶介导的LDL氧化，增加SCD小鼠的血管舒张，抑制哮喘小鼠嗜酸性粒细胞浸润和胶原蛋白沉积，抑制急性肺损伤，减少心脏缺血性损伤。
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公开(公告)号：US08937039B2
公开(公告)日：2015-01-20
申请号：US14081695
申请日：2013-11-15
申请人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, Jr.
发明人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, Jr.
CPC分类号： C07K5/0815 , A61K38/00 , C07K5/0821
摘要： The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.
摘要翻译： 本发明提供具有式AA1-AA2-AA3的肽类过氧化物酶抑制剂，其中AA1为带正电荷的带负电荷或中性氨基酸，AA2为氧化还原活性氨基酸，AA3为具有还原电位的氨基酸 使得AA3能够与氨基酸AA2的基团或其逆反相或类似物进行氧化还原反应。 这种组合的结果是高度有效的过氧化物酶活性抑制剂，其在广泛多样化的血管疾病和损伤模型中具有有效的抗炎特性。 示例性三肽有效抑制过氧化物酶介导的LDL氧化，增加SCD小鼠的血管舒张，抑制哮喘小鼠嗜酸性粒细胞浸润和胶原蛋白沉积，抑制急性肺损伤，减少心脏缺血性损伤。
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公开(公告)号：US20140194342A1
公开(公告)日：2014-07-10
申请号：US14081695
申请日：2013-11-15
申请人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, JR.
发明人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, JR.
IPC分类号： C07K5/09
CPC分类号： C07K5/0815 , A61K38/00 , C07K5/0821
摘要： The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.
摘要翻译： 本发明提供具有式AA1-AA2-AA3的肽类过氧化物酶抑制剂，其中AA1为带正电荷的带负电荷或中性氨基酸，AA2为氧化还原活性氨基酸，AA3为具有还原电位的氨基酸 使得AA3能够与氨基酸AA2的基团或其逆反相或类似物进行氧化还原反应。 这种组合的结果是高度有效的过氧化物酶活性抑制剂，其在广泛多样化的血管疾病和损伤模型中具有有效的抗炎特性。 示例性三肽有效抑制过氧化物酶介导的LDL氧化，增加SCD小鼠的血管舒张，抑制哮喘小鼠嗜酸性粒细胞浸润和胶原蛋白沉积，抑制急性肺损伤，减少心脏缺血性损伤。
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公开(公告)号：US08673847B2
公开(公告)日：2014-03-18
申请号：US13500040
申请日：2010-10-05
申请人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, Jr.
发明人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, Jr.
摘要： The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.
摘要翻译： 本发明提供具有式AA1-AA2-AA3的肽类过氧化物酶抑制剂，其中AA1为带正电荷的带负电荷或中性氨基酸，AA2为氧化还原活性氨基酸，AA3为具有还原电位的氨基酸 使得AA3能够与氨基酸AA2的基团或其逆反相或类似物进行氧化还原反应。 这种组合的结果是高度有效的过氧化物酶活性抑制剂，其在广泛多样化的血管疾病和损伤模型中具有有效的抗炎特性。 示例性三肽有效抑制过氧化物酶介导的LDL氧化，增加SCD小鼠的血管舒张，抑制哮喘小鼠嗜酸性粒细胞浸润和胶原蛋白沉积，抑制急性肺损伤，减少心脏缺血性损伤。
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公开(公告)号：US20070219129A1
公开(公告)日：2007-09-20
申请号：US11505036
申请日：2006-08-16
申请人： Kirkwood Pritchard , Hao Xu , Yang Shi
发明人： Kirkwood Pritchard , Hao Xu , Yang Shi
IPC分类号： A61K38/17
CPC分类号： A61K38/17
摘要： A method of inhibiting hsp90 association with eNOS in a patient, comprising the step of treating a patient with an effective amount of a pharmaceutical composition comprising an hsp90 decoy peptide.
摘要翻译： 一种抑制患者中与eNOS的hsp90结合的方法，包括用有效量的包含hsp90诱饵肽的药物组合物治疗患者的步骤。
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公开(公告)号：US08971061B2
公开(公告)日：2015-03-03
申请号：US12687035
申请日：2010-01-13
申请人： En Li , Yang Shi , Huanyu Lu , Junming Zhang , Yuancheng Ren
发明人： En Li , Yang Shi , Huanyu Lu , Junming Zhang , Yuancheng Ren
IPC分类号： H02M3/335
CPC分类号： H02M3/33507
摘要： The present invention provides an off time control method and switching regulator using it. The current flowing through a switch is compared with a current threshold, and the switch is turned off if the current flowing through the switch is larger than the current threshold. The off time of the switch is determined by the load. The current threshold is variable at light load to prevent generating the audible noise and improve the whole efficiency.
摘要翻译： 本发明提供一种关闭时间控制方法和使用它的开关调节器。 将流过开关的电流与电流阈值进行比较，并且如果流过开关的电流大于电流阈值，则开关断开。 开关的关闭时间由负载决定。 电流阈值在轻负载时可变，防止产生可听噪声，提高整体效率。
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7.发明授权Frequency limitation method with time hysteresis used in quasi-resonant control 有权用于准谐振控制的时滞的频率限制方法公开(公告)号：US08238123B2
公开(公告)日：2012-08-07
申请号：US12817002
申请日：2010-06-16
申请人： Junming Zhang , Yuanchang Ren , Jin Hu , Huanyu Lu , Yang Shi
发明人： Junming Zhang , Yuanchang Ren , Jin Hu , Huanyu Lu , Yang Shi
IPC分类号： H02M3/335
CPC分类号： H02M3/338 , H02M3/1563 , Y02B70/1425 , Y02B70/1433
摘要： A frequency limitation method used in quasi-resonant control of a switching regulator is disclosed. The switching frequency is limited through setting a minimum time limit, such as a minimum switching period or a minimum OFF time. The minimum time limit may be a first time limit or a second time limit. The minimum time limit is changed into another value if the minimum voltage point approaches the minimum time limit point, so as to eliminate the audible noise.
摘要翻译： 公开了一种用于开关调节器的准谐振控制的频率限制方法。 通过设置最小时间限制（例如最小切换周期或最小关闭时间）来限制开关频率。 最小时限可以是第一时限或第二时间限制。 如果最小电压点接近最小时限，则将最小时间限制改为另一个值，以消除可听见的噪声。
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公开(公告)号：US08223348B2
公开(公告)日：2012-07-17
申请号：US12332648
申请日：2008-12-11
申请人： Thomas D. Pawlik , Yang Shi , David J. Glacherio , John S. Badger
发明人： Thomas D. Pawlik , Yang Shi , David J. Glacherio , John S. Badger
CPC分类号： B41J11/009 , B41J2/1752 , B41J2/1753 , G03G15/6508 , G03G2215/00616 , G03G2215/00751
摘要： A printing system includes a media input location for storing a recording medium prior to transport within the printing system for subsequent printing; a light source directed toward an extended region of the media input location; an array of photosensors restricted to only a substantially perpendicular movement relative to a plane of the media input location; and an optical path including a first optical path section from the light source to the extended region of the media input location and a second optical path section from the extended region of the media input location to the array of photosensors.
摘要翻译： 打印系统包括用于在打印系统内传送之前存储记录介质以用于随后打印的介质输入位置; 指向所述媒体输入位置的扩展区域的光源; 光传感器阵列仅限于相对于介质输入位置的平面的基本上垂直的运动; 以及光路，其包括从介质输入位置的光源到扩展区域的第一光路部分和从介质输入位置的延伸区域到光电传感器阵列的第二光路部分。
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公开(公告)号：US20110218144A1
公开(公告)日：2011-09-08
申请号：US12971678
申请日：2010-12-17
申请人： John E. Baker , Yang Shi
发明人： John E. Baker , Yang Shi
CPC分类号： A61K38/196
摘要： A therapeutic or prophylactic treatment method of ischemia, such as due to myocardial infarction, by administering thrombopoietin, alone or in combination with other drugs, to a patient suffering from or at risk of cardiac injury, such as myocardial ischemia. The thrombopoietin is administered in a concentration such that the subject's platelet count or production of platelets is not significantly affected.
摘要翻译： 通过将血小板生成素单独或与其它药物组合施用于患有或有心脏损伤风险的患者（例如心肌缺血）的局部缺血的治疗或预防治疗方法，例如由于心肌梗塞。 血小板生成素的给药浓度使得受试者的血小板计数或血小板的产生不受显着影响。
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10.发明授权Method of reducing the effects of ischemia by administration of a thrombopoietin receptor ligand 有权通过给予血小板生成素受体配体减少缺血的作用的方法公开(公告)号：US07879318B2
公开(公告)日：2011-02-01
申请号：US11624030
申请日：2007-01-17
申请人： John E. Baker , Yang Shi
发明人： John E. Baker , Yang Shi
IPC分类号： C07K14/475 , C07K14/52 , C07K14/715
CPC分类号： A61K38/196
摘要： A therapeutic or prophylactic treatment method of ischemia, such as due to myocardial infarction, by administering thrombopoietin, alone or in combination with other drugs, to a patient suffering from or at risk of cardiac injury, such as myocardial ischemia. The thrombopoietin is administered in a concentration such that the subject's platelet count or production of platelets is not significantly affected.
摘要翻译： 通过将血小板生成素单独或与其它药物组合施用于患有或有心脏损伤风险的患者（例如心肌缺血）的局部缺血的治疗或预防治疗方法，例如由于心肌梗塞。 血小板生成素的给药浓度使得受试者的血小板计数或血小板的产生不受显着影响。
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