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公开(公告)号：US20120196789A1
公开(公告)日：2012-08-02
申请号：US13500040
申请日：2010-10-05
申请人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, JR.
发明人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, JR.
IPC分类号： A61K38/06 , A61P9/12 , A61P25/28 , A61P35/00 , A61P9/10 , A61P11/06 , A61P9/04 , A61P17/06 , A61P11/00 , A61P29/00 , A61P19/02 , A61P1/00 , A61P43/00 , A61P9/00 , A61P37/06 , A61P31/00 , A61P37/08 , A61P21/00 , A61P7/00 , A61P25/16 , C07K4/00 , C07K5/09 , A61P25/00
摘要： The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.
摘要翻译： 本发明提供具有式AA1-AA2-AA3的肽类过氧化物酶抑制剂，其中AA1为带正电荷的带负电荷或中性氨基酸，AA2为氧化还原活性氨基酸，AA3为具有还原电位的氨基酸 使得AA3能够与氨基酸AA2的基团或其逆反相或类似物进行氧化还原反应。 这种组合的结果是高度有效的过氧化物酶活性抑制剂，其在广泛多样化的血管疾病和损伤模型中具有有效的抗炎特性。 示例性三肽有效抑制过氧化物酶介导的LDL氧化，增加SCD小鼠的血管舒张，抑制哮喘小鼠嗜酸性粒细胞浸润和胶原蛋白沉积，抑制急性肺损伤，减少心脏缺血性损伤。
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公开(公告)号：US08937039B2
公开(公告)日：2015-01-20
申请号：US14081695
申请日：2013-11-15
申请人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, Jr.
发明人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, Jr.
CPC分类号： C07K5/0815 , A61K38/00 , C07K5/0821
摘要： The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.
摘要翻译： 本发明提供具有式AA1-AA2-AA3的肽类过氧化物酶抑制剂，其中AA1为带正电荷的带负电荷或中性氨基酸，AA2为氧化还原活性氨基酸，AA3为具有还原电位的氨基酸 使得AA3能够与氨基酸AA2的基团或其逆反相或类似物进行氧化还原反应。 这种组合的结果是高度有效的过氧化物酶活性抑制剂，其在广泛多样化的血管疾病和损伤模型中具有有效的抗炎特性。 示例性三肽有效抑制过氧化物酶介导的LDL氧化，增加SCD小鼠的血管舒张，抑制哮喘小鼠嗜酸性粒细胞浸润和胶原蛋白沉积，抑制急性肺损伤，减少心脏缺血性损伤。
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公开(公告)号：US20140194342A1
公开(公告)日：2014-07-10
申请号：US14081695
申请日：2013-11-15
申请人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, JR.
发明人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, JR.
IPC分类号： C07K5/09
CPC分类号： C07K5/0815 , A61K38/00 , C07K5/0821
摘要： The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.
摘要翻译： 本发明提供具有式AA1-AA2-AA3的肽类过氧化物酶抑制剂，其中AA1为带正电荷的带负电荷或中性氨基酸，AA2为氧化还原活性氨基酸，AA3为具有还原电位的氨基酸 使得AA3能够与氨基酸AA2的基团或其逆反相或类似物进行氧化还原反应。 这种组合的结果是高度有效的过氧化物酶活性抑制剂，其在广泛多样化的血管疾病和损伤模型中具有有效的抗炎特性。 示例性三肽有效抑制过氧化物酶介导的LDL氧化，增加SCD小鼠的血管舒张，抑制哮喘小鼠嗜酸性粒细胞浸润和胶原蛋白沉积，抑制急性肺损伤，减少心脏缺血性损伤。
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公开(公告)号：US08673847B2
公开(公告)日：2014-03-18
申请号：US13500040
申请日：2010-10-05
申请人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, Jr.
发明人： Hao Zhang , Yang Shi , Hao Xu , Kirkwood A. Pritchard, Jr.
摘要： The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.
摘要翻译： 本发明提供具有式AA1-AA2-AA3的肽类过氧化物酶抑制剂，其中AA1为带正电荷的带负电荷或中性氨基酸，AA2为氧化还原活性氨基酸，AA3为具有还原电位的氨基酸 使得AA3能够与氨基酸AA2的基团或其逆反相或类似物进行氧化还原反应。 这种组合的结果是高度有效的过氧化物酶活性抑制剂，其在广泛多样化的血管疾病和损伤模型中具有有效的抗炎特性。 示例性三肽有效抑制过氧化物酶介导的LDL氧化，增加SCD小鼠的血管舒张，抑制哮喘小鼠嗜酸性粒细胞浸润和胶原蛋白沉积，抑制急性肺损伤，减少心脏缺血性损伤。
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公开(公告)号：US11727583B2
公开(公告)日：2023-08-15
申请号：US17010372
申请日：2020-09-02
申请人： Hao Zhang , Stephen Dymmock , Nora Patricia Alarcon , Fei Le
发明人： Hao Zhang , Stephen Dymmock , Nora Patricia Alarcon , Fei Le
IPC分类号： G06T7/50 , E21B47/002 , G06T3/40 , E21B47/12
CPC分类号： G06T7/50 , E21B47/0025 , G06T3/4053 , E21B47/12
摘要： A method for characterizing a subsurface formation includes receiving image data of the subsurface formation obtained by a sensor tool and receiving a plurality of non-image data logs, each non-image data log being obtained by a different type of sensor tool. The method also includes performing an electrofacies analysis on the plurality of non-image data logs where the electrofacies analysis includes defining clusters wherein each cluster has a similar property to provide a plurality of electrofacies blocks with each electrofacies block representing a depth interval. The method further includes partitioning the image data into multiple high-resolution depth segments that share a similar property, feature, and/or pattern for each electrofacies block and assigning data from the plurality of non-image data logs into a corresponding high-resolution depth segment to provide a high-resolution data log that characterizes the subsurface formation.
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公开(公告)号：US11499686B1
公开(公告)日：2022-11-15
申请号：US17479736
申请日：2021-09-20
申请人： Daniel Machlis , Eva Lu , Hao Zhang
发明人： Daniel Machlis , Eva Lu , Hao Zhang
IPC分类号： F21S4/28 , F21V5/04 , F21Y103/10 , F21Y115/10
摘要： An x-axis curvable LED lighting system includes an elongated notched x-axis curved channel enclosed in a casing which can be freely bent without a machine having a bottom portion and one or more walls extending therefrom; an elongated lens to secure over a top of the elongated curved channel; and a flexible light strip, having a mounting strip to secure to one of the one or more walls of the elongated curved channel; LED lights attached to the mounting strip by an extension such that the LED lights are positioned within the elongated curved channel along the bottom portion; the LED lights emit light through the elongated lens.
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公开(公告)号：US20220017886A1
公开(公告)日：2022-01-20
申请号：US17497963
申请日：2021-10-10
申请人： Haiqin Chen , Bo Yang , He Gao , Jianxin Zhao , Yongquan Chen , Hao Zhang , Wei Chen
发明人： Haiqin Chen , Bo Yang , He Gao , Jianxin Zhao , Yongquan Chen , Hao Zhang , Wei Chen
摘要： Disclosed is linoleic acid isomerases and their application in production of conjugated linoleic acid, which belongs to the technical fields of protein engineering and microbial engineering. The linoleic acid isomerase derived from Bifidobacterium is used to produce the conjugated linoleic acid. The recombinant E. coli containing the linoleic acid isomerase of the invention is added into a reaction system containing linoleic acid and react for 3 h to produce conjugated linoleic acids. The conversion rate of the conjugated linoleic acid of the invented method ranges from 12.1% to 42.1%, and the percentage of cis9, trans11-CLA in the conjugated linoleic acid can reach 84.3% to 89.1%. The invention provides a method for using microorganisms to produce conjugated linoleic acids with high safety and yield where cis9, trans11-CLA isomer is the major form in the conjugated linoleic acid products.
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8.发明申请公开(公告)号：US20210403884A1
公开(公告)日：2021-12-30
申请号：US17469899
申请日：2021-09-09
申请人： Haiqin Chen , Wei Chen , Xin Tang , Jun Cao , Jianxin Zhao , Yongquan Chen , Hao Zhang
发明人： Haiqin Chen , Wei Chen , Xin Tang , Jun Cao , Jianxin Zhao , Yongquan Chen , Hao Zhang
摘要： Disclosed is a diacylglycerol acyltransferase 1, a recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1, and application thereof in production of triacylglycerol. The diacylglycerol acyltransferase 1 of the invention has a function of catalyzing synthesis of triacylglycerol. After the recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1 of the invention is subjected to induction culture for 48 h, the content of total fatty acid and triacylglycerol in the recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1 can be respectively increased by 1.94 folds and 12.09 folds as compared with those of Saccharomyces cerevisiae without the recombinant diacylglycerol acyltransferase 1. The instant invention provides a method for improving the ability of microorganisms to produce polyunsaturated fatty acids (PUFAs) by means of genetic engineering.
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公开(公告)号：US20190235109A1
公开(公告)日：2019-08-01
申请号：US15883817
申请日：2018-01-30
申请人： Hao Zhang , Alberto Mezzatesta
发明人： Hao Zhang , Alberto Mezzatesta
IPC分类号： G01V1/30 , E21B7/06 , G01V1/50 , C09K8/62 , E21B49/00 , G01V1/28 , G01V5/10 , G01V3/08 , G01V99/00
摘要： Examples of techniques for generating a high-resolution lithology model for subsurface formation evaluation are disclosed. In one example implementation according to aspects of the present disclosure, a computer-implemented method includes determining, by a processing device, a low-resolution lithology volumetric model. The method further includes comparing, by the processing device, the low-resolution lithology volumetric model to a high-resolution imaging log. The method further includes calculating, by the processing device, a dynamic boundary curve for each of a plurality of moving windows. The method further includes generating, by the processing device, the high-resolution lithology model based at least in part on the calculated dynamic boundary curve for each of the plurality of moving windows. The method further includes controlling a drilling operation based at least in part on the high-resolution lithology model.
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公开(公告)号：US09924563B2
公开(公告)日：2018-03-20
申请号：US12356438
申请日：2009-01-20
申请人： Sihai Ye , Xiaochun Cui , Bei Wang , Zhenhua Liu , Hualin Luo , Hao Zhang , Fudong Zeng
发明人： Sihai Ye , Xiaochun Cui , Bei Wang , Zhenhua Liu , Hualin Luo , Hao Zhang , Fudong Zeng
摘要： The disclosure provides a method for realizing a Mobile Switch Center (MSC) pool, a system for realizing an MSC pool and a Media Gateway (MGW). The method for realizing an MSC pool includes: connecting with a Base Station Controllers (BSC)/Radio Network Controller (RNC), by a Media Gateway (MGW) through the use of a common signaling point; and upon receipt of a message whose destination signaling point is the common signaling point from the BSC/RNC, determining, by the MGW, a destination MSC server of the message according to ID information carried in the message, and sending the received message to the destination MSC server. According to the present invention, the networking scheme for an MSC pool may be implemented without upgrading any BSC/RNC. The flexibility of the networking scheme for mobile communication systems may be improved, and the traffic load of the subscribers may be shared.
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