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1.发明申请PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS AND METHODS OF TREATING KINASE-ASSOCIATED CONDITIONS THEREWITH 审中-公开吡咯烷酮化合物有效地作为激酶抑制剂和治疗与激素相关的条件的方法公开(公告)号：US20100137319A1
公开(公告)日：2010-06-03
申请号：US12701405
申请日：2010-02-05
IPC分类号： A61K31/53 , C07D487/04 , A61P35/00 , A61P37/08 , A61P11/06 , A61P31/10 , A61P31/12 , A61P19/08 , A61P25/28 , A61P25/00 , A61P3/00
CPC分类号： C07D487/04
摘要： The invention relates to at least one pyrrolotriazine derivative, at least one pharmaceutical composition comprising at least one pyrrolotriazine derivative, and at least one method of using at least one pyrrolotriazine derivative to treat at least one kinase associated condition.
摘要翻译： 本发明涉及至少一种吡咯并三嗪衍生物，至少一种包含至少一种吡咯并三嗪衍生物的药物组合物和至少一种使用至少一种吡咯并三嗪衍生物以治疗至少一种激酶相关病症的方法。
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2.发明申请PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS AND METHODS OF TREATING KINASE-ASSOCIATED CONDITIONS THEREWITH 审中-公开吡咯烷酮化合物有效地作为激酶抑制剂和治疗与激素相关的条件的方法公开(公告)号：US20090062288A1
公开(公告)日：2009-03-05
申请号：US12260051
申请日：2008-10-28
IPC分类号： A61K31/53 , C07D253/10 , A61P35/00
CPC分类号： C07D487/04
摘要： The invention relates to at least one pyrrolotriazine derivative, at least one pharmaceutical composition comprising at least one pyrrolotriazine derivative, and at least one method of using at least one pyrrolotriazine derivative to treat at least one kinase associated condition.
摘要翻译： 本发明涉及至少一种吡咯并三嗪衍生物，至少一种包含至少一种吡咯并三嗪衍生物的药物组合物和至少一种使用至少一种吡咯并三嗪衍生物以治疗至少一种激酶相关病症的方法。
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3.发明授权Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith 有权可用作激酶抑制剂的吡咯并嗪化合物及其与激素相关病症的治疗方法公开(公告)号：US07442700B2
公开(公告)日：2008-10-28
申请号：US11426693
申请日：2006-06-27
IPC分类号： C07D403/12 , C07D403/14 , C07D487/04 , A61K31/53 , A61P19/02 , A61P35/00
CPC分类号： C07D487/04
摘要： The invention relates to at least one pyrrolotriazine derivative, at least one pharmaceutical composition comprising at least one pyrrolotriazine derivative, and at least one method of using at least one pyrrolotriazine derivative to treat at least one kinase associated condition.
摘要翻译： 本发明涉及至少一种吡咯并三嗪衍生物，至少一种包含至少一种吡咯并三嗪衍生物的药物组合物和至少一种使用至少一种吡咯并三嗪衍生物以治疗至少一种激酶相关病症的方法。
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公开(公告)号：US07141571B2
公开(公告)日：2006-11-28
申请号：US11019901
申请日：2004-12-22
申请人： Brian E. Fink , Ashvinikumar V. Gavai , Gregory D. Vite , Ping Chen , Harold Mastalerz , Derek J. Norris , John S. Tokarski , Yufen Zhao , Wen-Ching Han
发明人： Brian E. Fink , Ashvinikumar V. Gavai , Gregory D. Vite , Ping Chen , Harold Mastalerz , Derek J. Norris , John S. Tokarski , Yufen Zhao , Wen-Ching Han
IPC分类号： C07D487/04 , A61K31/53
CPC分类号： C07D487/04
摘要： The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
摘要翻译： 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制生长因子受体如HER1，HER2和HER4的酪氨酸激酶活性，从而使其成为抗增殖剂。 式I化合物还可用于治疗与通过生长因子受体操作的信号转导途径相关的其它疾病。
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公开(公告)号：US06916815B2
公开(公告)日：2005-07-12
申请号：US10736476
申请日：2003-12-15
IPC分类号： A61K20060101 , A61K31/53 , A61P13/08 , A61P19/02 , A61P29/00 , A61P37/00 , C07D20060101 , C07D487/02 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
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公开(公告)号：US07064203B2
公开(公告)日：2006-06-20
申请号：US11019899
申请日：2004-12-22
申请人： Ashvinikumar V. Gavai , Wen-Ching Han , Ping Chen , Edward H. Ruediger , Harold Mastalerz , Brian E. Fink , Derek J. Norris
发明人： Ashvinikumar V. Gavai , Wen-Ching Han , Ping Chen , Edward H. Ruediger , Harold Mastalerz , Brian E. Fink , Derek J. Norris
IPC分类号： C07D487/04 , A61K31/53 , A61P19/02
CPC分类号： C07D487/04
摘要： The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The compounds of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.
摘要翻译： 本发明提供式I化合物及其药学上可接受的盐。 本发明的化合物抑制生长因子受体如HER1，HER2和HER4的酪氨酸激酶活性，从而使其可用作治疗癌症和其它疾病的抗增殖剂。
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公开(公告)号：US07846931B2
公开(公告)日：2010-12-07
申请号：US11869910
申请日：2008-09-24
申请人： Brian E. Fink , Ashvinikumar V. Gavai , Gregory D. Vite , Ping Chen , Harold Mastalerz , Derek J. Norris , John S. Tokarski , Yufen Zhao , Wen-Ching Han
发明人： Brian E. Fink , Ashvinikumar V. Gavai , Gregory D. Vite , Ping Chen , Harold Mastalerz , Derek J. Norris , John S. Tokarski , Yufen Zhao , Wen-Ching Han
IPC分类号： A61K31/53 , A61P35/00 , C07D401/06 , C07D401/14
CPC分类号： C07D487/04
摘要： The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
摘要翻译： 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制生长因子受体如HER1，HER2和HER4的酪氨酸激酶活性，从而使其成为抗增殖剂。 式I化合物还可用于治疗与通过生长因子受体操作的信号转导途径相关的其它疾病。
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公开(公告)号：US07148220B2
公开(公告)日：2006-12-12
申请号：US11143279
申请日：2005-06-02
IPC分类号： A61K31/53 , A61P35/00 , C07D403/12 , C07D403/14
CPC分类号： C07D487/04
摘要： The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
摘要翻译： 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制生长因子受体如HER1，HER2和HER4的酪氨酸激酶活性，从而使其成为抗增殖剂。 式I化合物还可用于治疗与通过生长因子受体操作的信号转导途径相关的其它疾病。
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公开(公告)号：US07297695B2
公开(公告)日：2007-11-20
申请号：US11426479
申请日：2006-06-26
申请人： Brian E. Fink , Ashvinikumar V. Gavai , Gregory D. Vite , Ping Chen , Harold Mastalerz , Derek J. Norris , John S. Tokarski , Yufen Zhao , Wen-Ching Han
发明人： Brian E. Fink , Ashvinikumar V. Gavai , Gregory D. Vite , Ping Chen , Harold Mastalerz , Derek J. Norris , John S. Tokarski , Yufen Zhao , Wen-Ching Han
IPC分类号： C07D487/04 , C07D401/06 , C07D401/14 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
摘要翻译： 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制生长因子受体如HER1，HER2和HER4的酪氨酸激酶活性，从而使其成为抗增殖剂。 式I化合物还可用于治疗与通过生长因子受体操作的信号转导途径相关的其它疾病。
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公开(公告)号：US07102003B2
公开(公告)日：2006-09-05
申请号：US11157460
申请日：2005-06-21
申请人： Ashvinikumar V. Gavai , Harold Mastalerz , Jean-Paul Daris , Pierre Dextraze , Philippe Lapointe , Edward H. Ruediger , Dolatrai M. Vyas , Guifen Zhang
发明人： Ashvinikumar V. Gavai , Harold Mastalerz , Jean-Paul Daris , Pierre Dextraze , Philippe Lapointe , Edward H. Ruediger , Dolatrai M. Vyas , Guifen Zhang
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The compounds of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
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