摘要:
The present invention relates to compounds of the formula wherein R1 through R4, X, Y, m and n are defined as in the specification. Such compounds are useful exhibit activity as serotonin, norepinephrine and dopamine reuptake inhibitors, and their pharmaceutically acceptable salts, and their use in the treatment of central nervous system and other disorders.
摘要:
A tool for crimping work pieces to one another is disclosed. The tool is mounted on a power actuator having a reciprocating ram for effecting crimping. The tool includes a body engageable with the workpiece. A movable head is mounted on the body and receives the ram. A jaw is pivotably mounted on the body. A link connects the head to the jaw, which pivots in response to the ram engaging and moving the head. The jaw has a tooth that penetrates the work pieces upon pivoting of the jaw. Penetration of the work pieces by the tooth crimps the pieces to one another. A receiver is mounted on the body to permit its engagement with the actuator by means of an attachment device adapted to a particular actuator. The tool may be removably attachable to the actuator or permanently attached thereto.
摘要:
The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-�2-(4-fluorophenyl)ethyl!-4-piperidinemethanol, and its use in the treatment of a number of disease states.
摘要:
The present invention is directed to 5-HT.sub.2 antagonists and their use as agents in the treatment of obsessive-compulsive disorders (OCD). The invention is particularly directed to the compound (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol which is a member of a class of 5-HT.sub.2 antagonists known as N-aralkyl piperidinemethanol derivatives which are potent and selective inhibitors of the binding of serotonin at the 5-HT.sub.2 receptor site.
摘要:
The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol, and its use in the treatment of a number of disease states.
摘要:
The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-�2-(4-fluorophenyl)ethyl!-4-piperidinemethanol, and its use in the treatment of a number of disease states.
摘要:
The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol, and its use in the treatment of a number of disease states.