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公开(公告)号：US10426752B2
公开(公告)日：2019-10-01
申请号：US13258142
申请日：2009-04-01
申请人： Harsh M. Trivedi , Tao Xu , Davide Miksa , Cortney Worrell , Chanda Macias , Ying Yang , Yanan Hu
发明人： Harsh M. Trivedi , Tao Xu , Davide Miksa , Cortney Worrell , Chanda Macias , Ying Yang , Yanan Hu
摘要： The present invention discloses novel uses of specific menthol-derivative compounds of Formula 1, and compositions thereof, for methods of providing oral and systemic health care benefits, and methods of up-regulating or down-regulating periodontal disease metabolites: Formula 1 wherein, X is an oxygen atom or an NH radical; and R is an unsubstituted or substituted aryl or aliphatic radical. In some embodiments, the oral and systemic health care benefits include biofilm anti-attachment, anti-inflammation, anti-oxidant, anti-bone loss, and anti-microbial benefits. In some embodiments, the periodontal disease metabolites correspond to healthy and/or diseased oral status and allow differential diagnosis of oral health.
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2.发明申请MENTHOL-DERIVATIVE COMPOUNDS AND USE THEREOF AS ORAL AND SYSTEMIC ACTIVE AGENTS 审中-公开MENTHOL衍生化合物及其作为口服和系统活性剂的用途公开(公告)号：US20120014884A1
公开(公告)日：2012-01-19
申请号：US13258142
申请日：2009-04-01
申请人： Harsh M. Trivedi , Tao Xu , Davide Miksa , Cortney Worrell , Chanda Macias , Ying Yang , Yanan Hu
发明人： Harsh M. Trivedi , Tao Xu , Davide Miksa , Cortney Worrell , Chanda Macias , Ying Yang , Yanan Hu
IPC分类号： A61K31/27 , A61P31/00 , A61P19/08 , A61Q11/00 , A61P29/00 , A61P3/00 , A61P3/02 , A61P31/04 , A61K31/265 , A61P39/06
摘要： The present invention discloses novel uses of specific menthol-derivative compounds of Formula 1, and compositions thereof, for methods of providing oral and systemic health care benefits, and methods of up-regulating or down-regulating periodontal disease metabolites: Formula 1 wherein, X is an oxygen atom or an NH radical; and R is an unsubstituted or substituted aryl or aliphatic radical. In some embodiments, the oral and systemic health care benefits include biofilm anti-attachment, anti-inflammation, anti-oxidant, anti-bone loss, and anti-microbial benefits. In some embodiments, the periodontal disease metabolites correspond to healthy and/or diseased oral status and allow differential diagnosis of oral health.
摘要翻译： 本发明公开了具体的式1的薄荷醇衍生物化合物及其组合物的新用途，用于提供口服和全身保健益处的方法，以及上调或下调牙周病代谢物的方法：式1其中X 是氧原子或NH基; 并且R是未取代或取代的芳基或脂族基团。 在一些实施方案中，口服和全身保健益处包括生物膜抗附着，抗炎，抗氧化，抗骨丢失和抗微生物益处。 在一些实施方案中，牙周疾病代谢物对应于健康和/或患病的口腔状态并且允许口腔健康的鉴别诊断。
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3.发明授权Particles that disrupt or impede bacterial adhesion, related compositions and methods 失效破坏或阻碍细菌粘附的颗粒，相关组合物和方法公开(公告)号：US08211452B2
公开(公告)日：2012-07-03
申请号：US13358941
申请日：2012-01-26
申请人： Davide Miksa , Harsh M. Trivedi , Tao Xu
发明人： Davide Miksa , Harsh M. Trivedi , Tao Xu
IPC分类号： A61K8/02
CPC分类号： A61Q11/00 , A61K8/11 , A61K8/23 , A61K8/24 , A61K8/25 , A61K8/27 , A61K8/585 , A61K8/73 , A61K8/731 , A61K8/732 , A61K8/735 , A61K8/736 , A61K8/8129 , A61K8/8147 , A61K8/8176 , A61K8/87 , A61K8/88 , A61K2800/412 , A61K2800/413
摘要： Oral care and other compositions comprising particles having cores attached to bioadhesive polymers for inhibition of pellicle formation, plaque formation, biofilm formation, biofouling, and microbial adhesion or attachment are described. Methods using said compositions to treat surfaces, such as oral surfaces.
摘要翻译： 描述了包含具有连接到生物粘附聚合物的核心的颗粒的口腔护理和其它组合物，用于抑制防护薄膜形成，斑块形成，生物膜形成，生物结垢和微生物附着或附着。 使用所述组合物处理表面如口腔表面的方法。
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4.发明申请PARTICLES THAT DISRUPT OR IMPEDE BACTERIAL ADHESION, RELATED COMPOSITIONS AND METHODS 失效破坏或抑制细菌粘附的颗粒，相关组合物和方法公开(公告)号：US20120121672A1
公开(公告)日：2012-05-17
申请号：US13358941
申请日：2012-01-26
申请人： Davide Miksa , Harsh M. Trivedi , Tao Xu
发明人： Davide Miksa , Harsh M. Trivedi , Tao Xu
CPC分类号： A61Q11/00 , A61K8/11 , A61K8/23 , A61K8/24 , A61K8/25 , A61K8/27 , A61K8/585 , A61K8/73 , A61K8/731 , A61K8/732 , A61K8/735 , A61K8/736 , A61K8/8129 , A61K8/8147 , A61K8/8176 , A61K8/87 , A61K8/88 , A61K2800/412 , A61K2800/413
摘要： Oral care and other compositions comprising particles having cores attached to bioadhesive polymers for inhibition of pellicle formation, plaque formation, biofilm formation, biofouling, and microbial adhesion or attachment are described. Methods using said compositions to treat surfaces, such as oral surfaces.
摘要翻译： 描述了包含具有连接到生物粘附聚合物的核心的颗粒的口腔护理和其它组合物，用于抑制防护薄膜形成，斑块形成，生物膜形成，生物结垢和微生物附着或附着。 使用所述组合物处理表面如口腔表面的方法。
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公开(公告)号：US08119162B2
公开(公告)日：2012-02-21
申请号：US11271306
申请日：2005-11-10
申请人： Davide Miksa , Harsh M. Trivedi , Tao Xu
发明人： Davide Miksa , Harsh M. Trivedi , Tao Xu
CPC分类号： A61Q11/00 , A61K8/11 , A61K8/23 , A61K8/24 , A61K8/25 , A61K8/27 , A61K8/585 , A61K8/73 , A61K8/731 , A61K8/732 , A61K8/735 , A61K8/736 , A61K8/8129 , A61K8/8147 , A61K8/8176 , A61K8/87 , A61K8/88 , A61K2800/412 , A61K2800/413
摘要： Oral care and other compositions comprising particles having cores attached to bioadhesive polymers for inhibition of pellicle formation, plaque formation, biofilm formation, biofouling, and microbial adhesion or attachment are described. Methods using said compositions to treat surfaces, such as oral surfaces.
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公开(公告)号：US08617523B2
公开(公告)日：2013-12-31
申请号：US13260920
申请日：2009-04-01
申请人： Harsh M. Trivedi , Tao Xu , Davide Miksa
发明人： Harsh M. Trivedi , Tao Xu , Davide Miksa
IPC分类号： A61K8/00
CPC分类号： A61K31/265 , A61K8/37 , A61Q11/00
摘要： The present invention includes oral care compositions and methods for inhibiting growth and formation of oral biofilms by quorum sensing inhibition and/or bactericidal activity. In some embodiments, the present invention discloses an oral care composition including a therapeutically effective amount of at least one carbonate compound of Formula (1) and at least one excipient: wherein, R1 and R2 are independently: an aliphatic radical; a hydroxyaliphatic radical; or an aryl radical. In some embodiments, the present invention discloses a method of providing oral care benefits including applying to an oral cavity an oral care composition containing a therapeutically effective amount of at least one carbonate compound of Formula (1) and at least one excipient. In some embodiments, the present invention discloses a method of up-regulating or down-regulating periodontal disease metabolites including applying to an oral cavity an oral care composition containing a therapeutically effective amount of at least on carbonate compound of Formula (1) and at least one excipient.
摘要翻译： 本发明包括口腔护理组合物和通过群体感测抑制和/或杀菌活性抑制口腔生物膜生长和形成的方法。 在一些实施方案中，本发明公开了一种口腔护理组合物，其包含治疗有效量的至少一种式（1）的碳酸酯化合物和至少一种赋形剂：其中，R 1和R 2独立地为：脂族基团; 羟基脂肪族基团; 或芳基。 在一些实施方案中，本发明公开了一种提供口腔护理益处的方法，包括向口腔施用含有治疗有效量的至少一种式（1）的碳酸酯化合物和至少一种赋形剂的口腔护理组合物。 在一些实施方案中，本发明公开了一种上调或降低牙周病代谢物的方法，包括向口腔施用含有治疗有效量的至少一种式（1）的碳酸酯化合物的口腔护理组合物，并且至少 一种赋形剂
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公开(公告)号：US20120020896A1
公开(公告)日：2012-01-26
申请号：US13260920
申请日：2009-04-01
申请人： Harsh M. Trivedi , Davide Miksa , Tao Xu
发明人： Harsh M. Trivedi , Davide Miksa , Tao Xu
CPC分类号： A61K31/265 , A61K8/37 , A61Q11/00
摘要： The present invention includes oral care compositions and methods for inhibiting growth and formation of oral biofilms by quorum sensing inhibition and/or bactericidal activity. In some embodiments, the present invention discloses an oral care composition including a therapeutically effective amount of at least one carbonate compound of Formula (1) and at least one excipient: wherein, R1 and R2 are independently: an aliphatic radical; a hydroxyaliphatic radical; or an aryl radical. In some embodiments, the present invention discloses a method of providing oral care benefits including applying to an oral cavity an oral care composition containing a therapeutically effective amount of at least one carbonate compound of Formula (1) and at least one excipient. In some embodiments, the present invention discloses a method of up-regulating or down-regulating periodontal disease metabolites including applying to an oral cavity an oral care composition containing a therapeutically effective amount of at least on carbonate compound of Formula (1) and at least one excipient.
摘要翻译： 本发明包括口腔护理组合物和通过群体感测抑制和/或杀菌活性抑制口腔生物膜生长和形成的方法。 在一些实施方案中，本发明公开了一种口腔护理组合物，其包含治疗有效量的至少一种式（1）的碳酸酯化合物和至少一种赋形剂：其中，R 1和R 2独立地为：脂族基团; 羟基脂肪族基团; 或芳基。 在一些实施方案中，本发明公开了一种提供口腔护理益处的方法，包括向口腔施用含有治疗有效量的至少一种式（1）的碳酸酯化合物和至少一种赋形剂的口腔护理组合物。 在一些实施方案中，本发明公开了一种上调或降低牙周病代谢物的方法，包括向口腔施用含有治疗有效量的至少一种式（1）的碳酸酯化合物的口腔护理组合物，并且至少 一种赋形剂
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8.发明授权Protein biomarkers for soft tissue disease diagnosis and as therapeutic targets for oral care intervention 有权用于软组织疾病诊断的蛋白质生物标志物和用于口腔护理干预的治疗靶标公开(公告)号：US08753820B2
公开(公告)日：2014-06-17
申请号：US13262038
申请日：2010-04-01
申请人： Harsh M. Trivedi , Tao Xu , Ying Yang
发明人： Harsh M. Trivedi , Tao Xu , Ying Yang
CPC分类号： G01N33/56955 , G01N2333/96486 , G01N2800/60
摘要： Methods for identifying compounds useful for treating diseases or conditions of the oral cavity are described herein.
摘要翻译： 本文描述了用于鉴定可用于治疗口腔疾病或病症的化合物的方法。
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9.发明申请PROTEIN BIOMARKERS FOR SOFT TISSUE DISEASE DIAGNOSIS AND AS THERAPEUTIC TARGETS FOR ORAL CARE INTERVENTION 有权蛋白质生物标记物用于软组织病害诊断和用于口腔护理干预的治疗目标公开(公告)号：US20120028261A1
公开(公告)日：2012-02-02
申请号：US13262038
申请日：2010-04-01
申请人： Harsh M. Trivedi , Tao Xu , Ying Yang
发明人： Harsh M. Trivedi , Tao Xu , Ying Yang
IPC分类号： C12Q1/68 , G01N33/566 , G01N33/573
CPC分类号： G01N33/56955 , G01N2333/96486 , G01N2800/60
摘要： Methods for identifying compounds useful for treating diseases or conditions of the oral cavity are described herein.
摘要翻译： 本文描述了用于鉴定可用于治疗口腔疾病或病症的化合物的方法。
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公开(公告)号：US20120294915A1
公开(公告)日：2012-11-22
申请号：US13518103
申请日：2010-12-21
申请人： Wei Wang , Virginia Barnes , Harsh M. Trivedi , Tao Xu
发明人： Wei Wang , Virginia Barnes , Harsh M. Trivedi , Tao Xu
IPC分类号： A61K8/42 , A61P19/08 , A61K36/45 , B65D85/00 , A61K9/68 , A61K9/00 , A61Q11/00 , A61K31/265 , A61K8/02
CPC分类号： A61K8/42 , A61K8/347 , A61K8/368 , A61K8/37 , A61K8/97 , A61K31/05 , A61K31/19 , A61K31/265 , A61K31/27 , A61K36/324 , A61K36/45 , A61Q11/00 , C07C69/96 , C07C271/38
摘要： Described herein are compositions comprising a MMP-13 inhibitor, and methods of using the same.
摘要翻译： 本文描述的是包含MMP-13抑制剂的组合物及其使用方法。
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