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公开(公告)号:US08592597B2
公开(公告)日:2013-11-26
申请号:US13061078
申请日:2009-08-26
IPC分类号: C07D401/14
CPC分类号: A61K31/444 , C07D401/14
摘要: The present invention relates to a compound represented by the formula: wherein A is pyridyl group having at least one substituent wherein R1, R2 and R3 are each a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally substituted by halogen or a C1-6 alkoxy group optionally substituted by halogen, R4 and R6 are each a hydrogen atom, a halogen atom or a C1-6 alkyl group optionally substituted by halogen, R5 is a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally substituted by halogen or a C1-6 alkoxy group optionally substituted by halogen, and R7 is a hydrogen atom or a C1-6 alkyl group optionally substituted by halogen or a salt thereof, or a pharmaceutical composition containing the same.
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公开(公告)号:US20100056577A1
公开(公告)日:2010-03-04
申请号:US12547778
申请日:2009-08-26
IPC分类号: A61K31/444 , C07D401/14 , A61P1/04
CPC分类号: A61K31/444 , C07D401/14
摘要: The present invention relates to a compound represented by the formula: wherein A is pyridyl group having at least one substituent wherein R1, R2 and R3 are each a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally substituted by halogen or a C1-6 alkoxy group optionally substituted by halogen, R4 and R6 are each a hydrogen atom, a halogen atom or a C1-6 alkyl group optionally substituted by halogen, R5 is a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally substituted by halogen or a C1-6 alkoxy group optionally substituted by halogen, and R7 is a hydrogen atom or a C1-6 alkyl group optionally substituted by halogen or a salt thereof, or a pharmaceutical composition containing the same.
摘要翻译: 本发明涉及由下式表示的化合物:其中A是具有至少一个取代基的吡啶基,其中R 1,R 2和R 3各自为氢原子,卤素原子,任选被卤素取代的C 1-6烷基或 任选被卤素取代的C 1-6烷氧基,R 4和R 6各自为氢原子,卤素原子或任选被卤素取代的C 1-6烷基,R 5为氢原子,卤素原子,C 1-6烷基 任选被卤素取代或被卤素任意取代的C 1-6烷氧基,R 7是氢原子或任选被卤素或其盐取代的C 1-6烷基,或含有它们的药物组合物。
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公开(公告)号:US08969387B2
公开(公告)日:2015-03-03
申请号:US12547778
申请日:2009-08-26
IPC分类号: A61K31/4439 , C07D401/14 , A61K31/444
CPC分类号: A61K31/444 , C07D401/14
摘要: The present invention relates to a compound represented by the formula: wherein A is pyridyl group having at least one substituent wherein R1, R2 and R3 are each a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally substituted by halogen or a C1-6 alkoxy group optionally substituted by halogen, R4 and R6 are each a hydrogen atom, a halogen atom or a C1-6 alkyl group optionally substituted by halogen, R5 is a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally substituted by halogen or a C1-6 alkoxy group optionally substituted by halogen, and R7 is a hydrogen atom or a C1-6 alkyl group optionally substituted by halogen or a salt thereof, or a pharmaceutical composition containing the same.
摘要翻译: 本发明涉及由下式表示的化合物:其中A是具有至少一个取代基的吡啶基,其中R 1,R 2和R 3各自为氢原子,卤素原子,任选被卤素取代的C 1-6烷基或 任选被卤素取代的C 1-6烷氧基,R 4和R 6各自为氢原子,卤素原子或任选被卤素取代的C 1-6烷基,R 5为氢原子,卤素原子,C 1-6烷基 任选被卤素取代或被卤素任意取代的C 1-6烷氧基,R 7是氢原子或任选被卤素或其盐取代的C 1-6烷基,或含有它们的药物组合物。
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公开(公告)号:US20110172275A1
公开(公告)日:2011-07-14
申请号:US13061078
申请日:2009-08-26
IPC分类号: C07D401/14 , A61K31/444 , A61P1/00 , A61P1/04 , A61P35/04
CPC分类号: A61K31/444 , C07D401/14
摘要: The present invention relates to a compound represented by the formula: wherein A is pyridyl group having at least one substituent wherein R1, R2 and R3 are each a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally substituted by halogen or a C1-6 alkoxy group optionally substituted by halogen, R4 and R6 are each a hydrogen atom, a halogen atom or a C1-6 alkyl group optionally substituted by halogen, R5 is a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally substituted by halogen or a C1-6 alkoxy group optionally substituted by halogen, and R7 is a hydrogen atom or a C1-6 alkyl group optionally substituted by halogen or a salt thereof, or a pharmaceutical composition containing the same.
摘要翻译: 本发明涉及由下式表示的化合物:其中A是具有至少一个取代基的吡啶基,其中R 1,R 2和R 3各自为氢原子,卤素原子,任选被卤素取代的C 1-6烷基或 任选被卤素取代的C 1-6烷氧基,R 4和R 6各自为氢原子,卤素原子或任选被卤素取代的C 1-6烷基,R 5为氢原子,卤素原子,C 1-6烷基 任选被卤素取代或被卤素任意取代的C 1-6烷氧基,R 7是氢原子或任选被卤素或其盐取代的C 1-6烷基,或含有它们的药物组合物。
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公开(公告)号:US08895588B2
公开(公告)日:2014-11-25
申请号:US13260507
申请日:2010-03-25
申请人: Haruyuki Nishida , Ikuo Fujimori
发明人: Haruyuki Nishida , Ikuo Fujimori
IPC分类号: A61K31/4439 , C07D401/04
CPC分类号: C07D401/04
摘要: Provided is a compound having a superior acid secretion suppressive action, antiulcer activity and the like.A compound represented by the formula wherein R1 is a substituent, R2 is (i) a hydrogen atom, (ii) a C1-6 alkyl group optionally having a halogen atom or (iii) a cyano group, R3 is (i) a hydrogen atom, (ii) a halogen atom, (iii) a cyano group, (iv) a C1-6 alkyl group optionally having a halogen atom or a C1-6 alkoxy group optionally having a halogen atom, one of R2 and R3 is a hydrogen atom, and the other is a substituent other than a hydrogen atom, or a salt thereof.
摘要翻译: 提供具有优异的酸分泌抑制作用,抗溃疡活性等的化合物。 由下式表示的化合物其中R1是取代基,R2是(i)氢原子,(ii)任选具有卤素原子的C1-6烷基或(iii)氰基,R3是(i)氢 原子,(ii)卤素原子,(iii)氰基,(iv)任选具有卤素原子的C 1-6烷基或任选具有卤素原子的C 1-6烷氧基,R 2和R 3中的一个是 氢原子,另一个是氢原子以外的取代基或其盐。
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公开(公告)号:US20120095057A1
公开(公告)日:2012-04-19
申请号:US13260507
申请日:2010-03-25
申请人: Haruyuki Nishida , Ikuo Fujimori
发明人: Haruyuki Nishida , Ikuo Fujimori
IPC分类号: A61K31/4439 , A61P1/04 , A61P35/00 , C07D401/04
CPC分类号: C07D401/04
摘要: Provided is a compound having a superior acid secretion suppressive action, antiulcer activity and the like.A compound represented by the formula wherein R1 is a substituent, R2 is (i) a hydrogen atom, (ii) a C1-6 alkyl group optionally having a halogen atom or (iii) a cyano group, R3 is (i) a hydrogen atom, (ii) a halogen atom, (iii) a cyano group, (iv) a C1-6 alkyl group optionally having a halogen atom or (v) a C1-6 alkoxy group optionally having a halogen atom, one of R2 and R3 is a hydrogen atom, and the other is a substituent other than a hydrogen atom, or a salt thereof.
摘要翻译: 提供具有优异的酸分泌抑制作用,抗溃疡活性等的化合物。 由下式表示的化合物其中R1是取代基,R2是(i)氢原子,(ii)任选具有卤素原子的C1-6烷基或(iii)氰基,R3是(i)氢 原子,(ii)卤素原子,(iii)氰基,(iv)任选具有卤素原子的C 1-6烷基或(v)任选具有卤素原子的C 1-6烷氧基,R 2和 R3是氢原子,另一个是氢原子以外的取代基或其盐。
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公开(公告)号:US08703758B2
公开(公告)日:2014-04-22
申请号:US13094015
申请日:2011-04-26
申请人: Tohru Yamashita , Makoto Kamata , Hideki Hirose , Masataka Murakami , Takuya Fujimoto , Zenichi Ikeda , Tsuneo Yasuma , Ikuo Fujimori , Ryo Mizojiri , Tomoya Yukawa
发明人: Tohru Yamashita , Makoto Kamata , Hideki Hirose , Masataka Murakami , Takuya Fujimoto , Zenichi Ikeda , Tsuneo Yasuma , Ikuo Fujimori , Ryo Mizojiri , Tomoya Yukawa
IPC分类号: A01N43/00 , A61K31/00 , A01N43/42 , A61K31/44 , A01N43/76 , A61K31/42 , A01N43/56 , A61K31/415 , A01N43/08 , A61K31/34 , C07D413/14 , C07D405/02 , C07D401/02 , C07D401/14 , C07D403/02 , C07D491/048 , A61K31/41 , A61K31/439 , A61K31/444 , A61K31/4439
CPC分类号: C07D413/14 , A61K31/41 , A61K31/415 , A61K31/439 , A61K31/4439 , A61K31/444 , C07D231/54 , C07D263/56 , C07D263/58 , C07D307/81 , C07D401/02 , C07D401/14 , C07D403/02 , C07D405/02 , C07D413/04 , C07D417/04 , C07D487/08 , C07D491/048 , C07D498/04
摘要: The present invention provides to a compound having an ACC inhibitory action, which is useful as an agent for the prophylaxis or treatment of obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia, cancer and the like, and has superior efficacy.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification.
摘要翻译: 本发明提供具有ACC抑制作用的化合物,其可用作预防或治疗肥胖症,糖尿病,高血压,高脂血症,心力衰竭,糖尿病并发症,代谢综合征,肌肉减少症,癌症等的药剂,以及 具有优越的疗效。 本发明涉及由式(I)表示的化合物:其中每个符号如说明书中所定义。
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公开(公告)号:US08722662B2
公开(公告)日:2014-05-13
申请号:US13253293
申请日:2011-10-05
申请人: Yuji Ishichi , Masami Yamada , Taku Kamei , Ikuo Fujimori , Yoshihisa Nakada , Tomoya Yukawa , Nobuki Sakauchi , Yusuke Ohba , Tetsuya Tsukamoto
发明人: Yuji Ishichi , Masami Yamada , Taku Kamei , Ikuo Fujimori , Yoshihisa Nakada , Tomoya Yukawa , Nobuki Sakauchi , Yusuke Ohba , Tetsuya Tsukamoto
IPC分类号: A61K31/55 , C07D267/10 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/14
CPC分类号: C07D267/10 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/08
摘要: Provided is a compound having a monoamine reuptake inhibitory activity, which is represented by the formula (I) wherein ring A is an optionally substituted 6-membered aromatic ring, ring B is the substituents on ring A are optionally bonded to form, together with ring A, an optionally substituted 9- or 10-membered aromatic fused ring, and other symbols are as defined in the specification, or a salt thereof.
摘要翻译: 提供具有单胺再摄取抑制活性的化合物,其由式(I)表示,其中环A是任选取代的6元芳环,环B是环A上的取代基任选地键合以与环一起形成 A,任选取代的9元或10元芳族稠环,以及其它符号如说明书中所定义,或其盐。
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公开(公告)号:US20110263562A1
公开(公告)日:2011-10-27
申请号:US13094015
申请日:2011-04-26
申请人: Tohru Yamashita , Makoto Kamata , Hideki Hirose , Masataka Murakami , Takuya Fujimoto , Zenichi Ikeda , Tsuneo Yasuma , Ikuo Fujimori , Ryo Mizojiri , Tomoya Yukawa
发明人: Tohru Yamashita , Makoto Kamata , Hideki Hirose , Masataka Murakami , Takuya Fujimoto , Zenichi Ikeda , Tsuneo Yasuma , Ikuo Fujimori , Ryo Mizojiri , Tomoya Yukawa
IPC分类号: A61K31/423 , A61K31/438 , A61K31/439 , C07D417/04 , A61K31/454 , A61K31/416 , A61K31/34 , C07D498/04 , C07D413/14 , C07D413/04 , C07D263/56 , C07D231/56 , C07D307/87 , A61P35/04 , A61P3/04 , A61P3/06 , A61P9/12 , A61P9/00 , A61P3/10 , A61P3/00 , A61K31/497
CPC分类号: C07D413/14 , A61K31/41 , A61K31/415 , A61K31/439 , A61K31/4439 , A61K31/444 , C07D231/54 , C07D263/56 , C07D263/58 , C07D307/81 , C07D401/02 , C07D401/14 , C07D403/02 , C07D405/02 , C07D413/04 , C07D417/04 , C07D487/08 , C07D491/048 , C07D498/04
摘要: The present invention provides to a compound having an ACC inhibitory action, which is useful as an agent for the prophylaxis or treatment of obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia, cancer and the like, and has superior efficacy.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification.
摘要翻译: 本发明提供具有ACC抑制作用的化合物,其可用作预防或治疗肥胖症,糖尿病,高血压,高脂血症,心力衰竭,糖尿病并发症,代谢综合征,肌肉减少症,癌症等的药剂,以及 具有优越的疗效。 本发明涉及由式(I)表示的化合物:其中每个符号如说明书中所定义。
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公开(公告)号:US20130267494A1
公开(公告)日:2013-10-10
申请号:US13877810
申请日:2011-10-05
申请人: Yuji Ishichi , Masami Yamada , Taku Kamei , Ikuo Fujimori , Yoshihisa Nakada , Tomoya Yukawa , Nobuki Sakauchi , Yusuke Ohba , Tetsuya Tsukamoto
发明人: Yuji Ishichi , Masami Yamada , Taku Kamei , Ikuo Fujimori , Yoshihisa Nakada , Tomoya Yukawa , Nobuki Sakauchi , Yusuke Ohba , Tetsuya Tsukamoto
IPC分类号: C07D267/10 , C07D413/06 , C07D413/12 , C07D417/12 , C07D413/14 , C07D498/08
CPC分类号: C07D267/10 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/08
摘要: Provided is a compound having a monoamine reuptake inhibitory activity, which is represented by the formula (I) wherein ring A is an optionally substituted 6-membered aromatic ring, ring B is the substituents on ring A are optionally bonded to form, together with ring A, an optionally substituted 9- or 10-membered aromatic fused ring, and other symbols are as defined in the specification, or a salt thereof.
摘要翻译: 提供具有单胺再摄取抑制活性的化合物,其由式(I)表示,其中环A是任选取代的6元芳环,环B是环A上的取代基任选地键合以与环一起形成 A,任选取代的9元或10元芳族稠环,以及其它符号如说明书中所定义,或其盐。
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