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    PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING AN HYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID
    2.
    发明申请
    PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING AN HYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID 有权
    生产包含水溶性2-O-ALPHA-D-葡萄糖-L-抗坏血酸的颗粒组合物的方法

    公开(公告)号：US20160024131A1

    公开(公告)日：2016-01-28

    申请号：US14879280

    申请日：2015-10-09

    申请人： Hayashibara Co., Ltd.

    发明人： Takashi SHIBUYA ,  Seisuke IZAWA ,  Tomoyuki NISHIMOTO ,  Shigeharu FUKUDA ,  Toshio MIYAKE

    IPC分类号： C07H17/04

    CPC分类号： A61K31/7048 ,  A61K9/16 ,  C07H17/04 ,  C12P19/18 ,  C12P19/60 ,  C12Y204/01019

    摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.

    摘要翻译： 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

    PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING AN HYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID
    4.
    发明申请
    PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING AN HYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID 有权
    生产包含水溶性2-O-ALPHA-D-葡萄糖-L-抗坏血酸的颗粒组合物的方法

    公开(公告)号：US20140348922A1

    公开(公告)日：2014-11-27

    申请号：US14295546

    申请日：2014-06-04

    申请人： Hayashibara Co., Ltd.

    发明人： Takashi SHIBUYA ,  Seisuke IZAWA ,  Tomoyuki NISHIMOTO ,  Shigeharu FUKUDA ,  Toshio MIYAKE

    IPC分类号： A61K31/7048 ,  A61K9/16

    CPC分类号： A61K31/7048 ,  A61K9/16 ,  C07H17/04 ,  C12P19/18 ,  C12P19/60 ,  C12Y204/01019

    摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.

    摘要翻译： 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

    EXTERNAL DERMATOLOGICAL AGENT FOR ANTI-AGEING
    6.
    发明申请
    EXTERNAL DERMATOLOGICAL AGENT FOR ANTI-AGEING 审中-公开
    外用抗真菌剂

    公开(公告)号：US20170035676A1

    公开(公告)日：2017-02-09

    申请号：US15304181

    申请日：2015-04-13

    申请人： Hayashibara Co., Ltd.

    发明人： Keizo KOHNO ,  Satomi MIYATA ,  Toshiharu HANAYA ,  Shigeharu FUKUDA

    IPC分类号： A61K8/60 ,  A61K8/44 ,  A61Q19/08

    CPC分类号： A61K8/606 ,  A61K8/44 ,  A61K8/498 ,  A61K8/676 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7076 ,  A61Q19/02 ,  A61Q19/08

    摘要： The present invention aims to provide an external dermal composition for anti-ageing, which prevents or improves apparent skin problems such as age-related or senescent wrinkles, fine wrinkles, saggings, spots, etc., as well as maintaining or enhancing the skin barrier functions. The object is solved by providing an external dermal agent for anti-ageing, which contains as an effective ingredient(s) one or more members selected from the group consisting of adenosine N1-oxide 5′-phosphate, analogues thereof, and their salts.

    摘要翻译： 本发明的目的在于提供一种用于抗衰老的外用皮肤组合物，其可防止或改善诸如年龄相关或衰老皱纹，细纹，皱纹，斑点等的明显皮肤问题，以及维持或增强皮肤屏障 功能。 该目的通过提供一种抗衰老的外用皮肤试剂来解决，该外用皮肤试剂含有一种或多种选自下列的一种或多种成分：腺苷N-氧化物5'-磷酸酯，其类似物及其盐。

    FLUID FOR PERITONEAL DIALYSIS
    8.
    发明申请
    FLUID FOR PERITONEAL DIALYSIS 有权
    流体用于透析

    公开(公告)号：US20140148409A1

    公开(公告)日：2014-05-29

    申请号：US14169518

    申请日：2014-01-31

    申请人： HAYASHIBARA CO. LTD

    发明人： Hitomi OHTA ,  Toshiharu HANAYA ,  Shigeharu FUKUDA ,  Yoshikatsu MIWA ,  Toshio MIYAKE

    IPC分类号： A61K31/716

    CPC分类号： A61K31/716 ,  A61K31/702 ,  A61K31/7048 ,  A61M1/287 ,  A61K2300/00

    摘要： The present invention has an object to provide a fluid for peritoneal dialysis with satisfactory body fluid removability, high biocompatibility, and improved storage stability, and the object is attained by a fluid for peritoneal dialysis containing one or more saccharides selected from cyclonigerosylnigerose, cyclomaltosylmaltose, and L-ascorbic acid 2-glucoside.

    摘要翻译： 本发明的目的是提供一种用于腹膜透析的流体，其具有令人满意的体液清除性，高生物相容性和改善的储存稳定性，并且目的是通过含有一种或多种选自旋风黑素糖， L-抗坏血酸2-葡萄糖苷。