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公开(公告)号:US08637511B2
公开(公告)日:2014-01-28
申请号:US12796297
申请日:2010-06-08
申请人: Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sham Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
发明人: Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sham Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
IPC分类号: A61K31/506 , A61K31/5355 , A61P29/00 , A61P19/08 , A61P3/00 , A61P25/28 , A61P35/00 , A61P9/00 , A61P37/08
CPC分类号: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病,病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号:US20120142660A1
公开(公告)日:2012-06-07
申请号:US13309970
申请日:2011-12-02
申请人: Hayley Binch , Michael Mortimore , Damien Fraysse , Chris Davis , Michael O'Donnell , Simon Everitt , Daniel Robinson , Joanne Pinder , Andrew Miller
发明人: Hayley Binch , Michael Mortimore , Damien Fraysse , Chris Davis , Michael O'Donnell , Simon Everitt , Daniel Robinson , Joanne Pinder , Andrew Miller
IPC分类号: A61K31/506 , A61P35/00 , C07D403/14
CPC分类号: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病,病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号:US20070259869A1
公开(公告)日:2007-11-08
申请号:US11592114
申请日:2006-11-03
申请人: Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sharn Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
发明人: Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sharn Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
IPC分类号: A61K31/506 , A61K31/496 , A61K31/517 , A61K31/5377 , A61P35/00 , A61P35/02 , C07D239/47 , C07D239/48 , C07D239/50 , C07D413/14 , C12N5/02
CPC分类号: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病,病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号:US20070249031A1
公开(公告)日:2007-10-25
申请号:US11592119
申请日:2006-11-03
申请人: Hayley Binch , Michael Mortimore , Damien Fraysse , Chris Davis , Michael O'Donnell , Simon Everitt , Daniel Robinson , Joanne Pinder , Andrew Miller
发明人: Hayley Binch , Michael Mortimore , Damien Fraysse , Chris Davis , Michael O'Donnell , Simon Everitt , Daniel Robinson , Joanne Pinder , Andrew Miller
IPC分类号: A61K31/505 , A61P35/00 , C07D239/02 , C12N9/99
CPC分类号: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
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公开(公告)号:US07767672B2
公开(公告)日:2010-08-03
申请号:US11592114
申请日:2006-11-03
申请人: Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sharn Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
发明人: Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sharn Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
IPC分类号: A61K31/506 , A61K31/5355 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14 , C07D205/04 , C07D215/36 , C07D209/34 , C07C225/06 , A61P29/00 , A61P35/00 , A61P27/14
CPC分类号: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病,病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号:US08129399B2
公开(公告)日:2012-03-06
申请号:US12410553
申请日:2009-03-25
申请人: Hayley Binch , Michael Mortimore , Damien Fraysse , Chris Davis , Michael O'Donnell , Simon Everitt , Daniel Robinson , Joanne Pinder , Andrew Miller
发明人: Hayley Binch , Michael Mortimore , Damien Fraysse , Chris Davis , Michael O'Donnell , Simon Everitt , Daniel Robinson , Joanne Pinder , Andrew Miller
IPC分类号: C07D403/14 , A61K31/4155
CPC分类号: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病,病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号:US20100310675A1
公开(公告)日:2010-12-09
申请号:US12796297
申请日:2010-06-08
申请人: Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sharn Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
发明人: Hayley Binch , Michael Mortimore , Chris Davis , Dean Boyall , Simon Everitt , Daniel Robinson , Sharn Ramaya , Damien Fraysse , John Studley , Andrew Miller , Michael O'Donnell , Alistair Rutherford , Joanne Pinder
IPC分类号: A61K31/506 , A61K31/5377 , A61K31/517 , A61K33/24 , A61K31/704 , A61P35/00 , A61P35/02 , C12N9/99 , A61K31/397
CPC分类号: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病,病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号:US20090181938A1
公开(公告)日:2009-07-16
申请号:US12410553
申请日:2009-03-25
申请人: Hayley Binch , Michael Mortimore , Damien Fraysse , Chris Davis , Michael O'Donnell , Simon Everitt , Daniel Robinson , Joanne Pinder , Andrew Miller
发明人: Hayley Binch , Michael Mortimore , Damien Fraysse , Chris Davis , Michael O'Donnell , Simon Everitt , Daniel Robinson , Joanne Pinder , Andrew Miller
IPC分类号: A61K31/506 , C07D403/14 , A61P35/00
CPC分类号: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病,病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号:US07528142B2
公开(公告)日:2009-05-05
申请号:US11592119
申请日:2006-11-03
申请人: Hayley Binch , Michael Mortimore , Damien Fraysse , Chris Davis , Michael O'Donnell , Simon Everitt , Daniel Robinson , Joanne Pinder , Andrew Miller
发明人: Hayley Binch , Michael Mortimore , Damien Fraysse , Chris Davis , Michael O'Donnell , Simon Everitt , Daniel Robinson , Joanne Pinder , Andrew Miller
IPC分类号: C07D403/14 , A61K31/4155
CPC分类号: C07D403/12 , C07D239/38 , C07D401/14 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病,病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号:US20100137305A1
公开(公告)日:2010-06-03
申请号:US12562181
申请日:2009-09-18
申请人: Hayley Binch , Stephen Young , Christopher Davis , Michael Mortimore , John Studley , Daniel Robinson , Michael O'Donnell , Dean Boyall , Joanne Pinder , Simon Everitt , Julian Golec
发明人: Hayley Binch , Stephen Young , Christopher Davis , Michael Mortimore , John Studley , Daniel Robinson , Michael O'Donnell , Dean Boyall , Joanne Pinder , Simon Everitt , Julian Golec
IPC分类号: A61K31/5377 , A61K31/506 , C07D413/14 , A61P35/00 , C07D403/14 , A61P35/02
CPC分类号: C07D471/04 , C07D403/14 , C07D413/14 , C07D417/14
摘要: The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
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