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    Modified Hydrocyanine Dyes for the Detection of Reactive Oxygen Species
    1.
    发明申请
    Modified Hydrocyanine Dyes for the Detection of Reactive Oxygen Species 审中-公开
    用于检测活性氧物质的改性水解染料

    公开(公告)号：US20130287689A1

    公开(公告)日：2013-10-31

    申请号：US13881672

    申请日：2011-11-01

    申请人： Hee Chol Kang ,  Kyle Gee ,  Bhaskar Mandavilli ,  Lai-Qiang Ying ,  Bruce Branchaud

    发明人： Hee Chol Kang ,  Kyle Gee ,  Bhaskar Mandavilli ,  Lai-Qiang Ying ,  Bruce Branchaud

    IPC分类号： G01N21/64 ,  C09B57/00

    CPC分类号： G01N21/6486 ,  C09B23/06 ,  C09B23/08 ,  C09B23/083 ,  C09B57/00

    摘要： The present invention is directed to compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced dyes, including Cy-based hydrocyanine dyes and Cy-based deuterocyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits.

    摘要翻译： 本发明涉及通过常规荧光显微镜，荧光光谱，流式细胞术和/或高含量成像检测活性氧（ROS）的化合物，组合物，方法和试剂盒。 本文公开的化合物是新的还原染料，包括基于Cy的氢化花青染料和Cy-基氘异氰染料，其染料是用于检测ROS的探针和测量体外和/或体内细胞中的氧化应激。 本文还描述了用于制备用于所公开的组合物，方法和试剂盒的新型还原染料即ROS探针的方法。

    Nanocrystals with functional ligands
    8.
    发明授权
    Nanocrystals with functional ligands 有权
    具有功能性配体的纳米晶体

    公开(公告)号：US08901333B2

    公开(公告)日：2014-12-02

    申请号：US13122094

    申请日：2009-09-30

    申请人： Eric Tulsky ,  Eric Welch ,  Bruce Branchaud ,  Roman Rozhkov

    发明人： Eric Tulsky ,  Eric Welch ,  Bruce Branchaud ,  Roman Rozhkov

    IPC分类号： C07F9/02 ,  B32B5/16 ,  C09K11/02

    CPC分类号： C09K11/025 ,  C09K11/883 ,  Y10T428/2998

    摘要： Coated fluorescent semiconductor nanoparticles having an organic surface layer of multi-functional surface ligands that include a nanocrystal binding center and one or more covalently attached functional groups or reactive functional groups are described as well as water-dispersible nanoparticles having an organic surface layer or multi-functional surface ligands and methods for the preparation and use of such coated nanoparticles.

    摘要翻译： 描述了具有包括纳米晶体结合中心和一个或多个共价连接的官能团或反应性官能团的多功能表面配体的有机表面层的涂覆的荧光半导体纳米颗粒以及具有有机表面层或多层结构的水分散性纳米颗粒， 功能性表面配体和用于制备和使用这种包被的纳米颗粒的方法。

    Compositions and methods for stabilizing susceptible compounds
    10.
    发明授权
    Compositions and methods for stabilizing susceptible compounds 审中-公开

    公开(公告)号：US10669522B2

    公开(公告)日：2020-06-02

    申请号：US13984263

    申请日：2012-02-07

    申请人： Richard Fike ,  Bruce Branchaud ,  Shawn Barrett

    发明人： Richard Fike ,  Bruce Branchaud ,  Shawn Barrett

    IPC分类号： C12N5/00

    摘要： Methods for increasing the stability of, or protecting, labile components, such as ethanolamine, growth factors, vitamins, etc., in compositions such as a cell culture medium, are described. Stability of the labile compound is increased either, by derivatization or by sequestering the labile compound. Sequestering can be done either by encapsulation within a microcapsule or by the use of sequestering agents. Encapsulation can provide controlled release of the susceptible compound being protected. These methods may improve or extend the storage conditions, the shipping and handling of media compositions comprising the labile compounds at room temperature rather than at lower temperatures, thereby decreasing shipping costs.