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公开(公告)号：US08182464B2
公开(公告)日：2012-05-22
申请号：US12709551
申请日：2010-02-22
申请人： Heejin Lee , Karen Danielle Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
发明人： Heejin Lee , Karen Danielle Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
IPC分类号： A61M31/00 , A01N43/04 , A01N37/12 , A01N37/44 , A01N43/38 , A01N37/18 , A01N59/02 , A61K31/24 , A61K31/40 , A61K31/16 , A61K33/04
CPC分类号： A61M31/002 , A61K9/0034 , A61L29/06 , A61L29/16 , A61L2300/402 , A61L2300/406 , A61L2300/45 , A61L2300/63 , A61M2202/06 , A61M2205/0216 , A61M2210/1085 , C08L83/04
摘要： Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.
摘要翻译： 用于膀胱内给药和局部药物输送的植入装置。 该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。 该装置构造成用于微创地插入诸如膀胱的体腔中。 中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在 体腔。 身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。
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公开(公告)号：US08343516B2
公开(公告)日：2013-01-01
申请号：US12825238
申请日：2010-06-28
CPC分类号： A61K9/0004 , A61K9/0034 , A61K9/2004 , A61K9/2027 , A61K9/2031 , A61K9/2072 , A61K9/2095 , A61K31/16 , A61K31/165 , A61K31/167 , A61M31/002 , A61M31/007 , A61M2202/06 , B65B1/16
摘要： A drug dosage form is provided in the form of a solid tablet which is greater than 50% by weight the local anesthetic agent. The local anesthetic agent may be selected from the group consisting of an aminoamide, an aminoester, and a combination thereof. The drug tablet may be in the form of a mini-tablet which is greater than 70 wt % drug, with the balance being excipient. For example, the anesethetic agent may include lidocaine, in a salt or base form, combined with binder and lubricant excipients. Implantable drug delivery devices including the tablets are also provided, e.g., one or more of the drug tablets may be contained in a biocompatible housing. The drug tablets may be substantially cylindrical with flat end faces, and the device may have from 10 to 100 drug tablets aligned in the housing with the flat end faces of adjacent tablets abutting one another.
摘要翻译： 以固体片剂的形式提供药物剂型，其大于当量麻醉剂的50重量％。 局部麻醉剂可以选自氨基酰胺，氨基酯及其组合。 药片可以是大于70重量％的药物的微型片剂，其余为赋形剂。 例如，麻醉剂可以包括盐或碱形式的利多卡因，与粘合剂和润滑剂赋形剂组合。 还提供了包括片剂在内的可植入药物递送装置，例如药物片剂中的一种或多种可以包含在生物相容的壳体中。 药物片剂可以是具有平坦端面的大致圆柱形，并且该装置可以具有在壳体中对齐的10至100个药物片剂，相邻片剂的平坦端面彼此邻接。
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公开(公告)号：US20100330149A1
公开(公告)日：2010-12-30
申请号：US12825238
申请日：2010-06-28
IPC分类号： A61K31/167 , A61K9/00 , A61P13/10
CPC分类号： A61K9/0004 , A61K9/0034 , A61K9/2004 , A61K9/2027 , A61K9/2031 , A61K9/2072 , A61K9/2095 , A61K31/16 , A61K31/165 , A61K31/167 , A61M31/002 , A61M31/007 , A61M2202/06 , B65B1/16
摘要： A drug dosage form is provided in the form of a solid tablet which is greater than 50% by weight the local anesthetic agent. The local anesthetic agent may be selected from the group consisting of an aminoamide, an aminoester, and a combination thereof. The drug tablet may be in the form of a mini-tablet which is greater than 70 wt % drug, with the balance being excipient. For example, the anesethetic agent may include lidocaine, in a salt or base form, combined with binder and lubricant excipients. Implantable drug delivery devices including the tablets are also provided, e.g., one or more of the drug tablets may be contained in a biocompatible housing. The drug tablets may be substantially cylindrical with flat end faces, and the device may have from 10 to 100 drug tablets aligned in the housing with the flat end faces of adjacent tablets abutting one another.
摘要翻译： 以固体片剂的形式提供药物剂型，其大于当量麻醉剂的50重量％。 局部麻醉剂可以选自氨基酰胺，氨基酯及其组合。 药片可以是大于70重量％的药物的微型片剂，其余为赋形剂。 例如，麻醉剂可以包括盐或碱形式的利多卡因，与粘合剂和润滑剂赋形剂组合。 还提供了包括片剂在内的可植入药物递送装置，例如药物片剂中的一种或多种可以包含在生物相容的壳体中。 药物片剂可以是具有平坦端面的大致圆柱形，并且该装置可以具有在壳体中对齐的10至100个药物片剂，相邻片剂的平坦端面彼此邻接。
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