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    Implantable Drug Delivery Device with Bladder Retention Feature
    5.
    发明申请
    Implantable Drug Delivery Device with Bladder Retention Feature 有权
    具有膀胱保留特征的可植入药物输送装置

    公开(公告)号：US20120089121A1

    公开(公告)日：2012-04-12

    申请号：US13267469

    申请日：2011-10-06

    申请人： Heejin Lee ,  Hong Linh Ho Duc

    发明人： Heejin Lee ,  Hong Linh Ho Duc

    IPC分类号： A61M31/00

    CPC分类号： A61M31/002 ,  A61K9/0034 ,  A61K9/0065 ,  A61K9/20 ,  A61K31/167 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/402 ,  A61M2210/1085

    摘要： Implantable devices and methods for controlled drug delivery are provided. The device includes a device structure deformable between a retention shape and a low profile shape for deployment in the bladder of a patient and has a drug reservoir lumen in which a drug formulation is housed. The device also includes a buoyancy retention portion, which includes a volume of entrapped air or a gas-generating or effervescent powder Which will generate a volume of entrapped air following contact with urine in the bladder. The buoyancy retention portion may include a water permeable and/or biodegradable wall, which can release the entrapped air following drug release, to cause the device to sink into the bladder neck to facilitate device expulsion without the need for a device retrieval medical procedure.

    摘要翻译： 提供了用于受控药物递送的可植入装置和方法。 该装置包括可在保持形状和低轮廓形状之间变形的装置结构，用于展开在患者的膀胱中，并且具有容纳药物制剂的药物储存器腔。 该装置还包括浮力保持部分，其包括一定量的夹带空气或气体产生或泡腾粉末，其将在与膀胱中的尿液接触之后产生一定量的夹带空气。 浮力保持部分可以包括水可渗透的和/或可生物降解的壁，其可以在药物释放之后释放夹带的空气，以使得装置沉入膀胱颈部以促进装置排出而不需要装置取回医学程序。

    Implantable drug delivery device with bladder retention feature
    6.
    发明授权
    Implantable drug delivery device with bladder retention feature 有权
    具有膀胱保留功能的植入式药物输送装置

    公开(公告)号：US09457176B2

    公开(公告)日：2016-10-04

    申请号：US13267469

    申请日：2011-10-06

    申请人： Heejin Lee ,  Hong Linh Ho Duc

    发明人： Heejin Lee ,  Hong Linh Ho Duc

    IPC分类号： A61M31/00 ,  A61K9/00

    CPC分类号： A61M31/002 ,  A61K9/0034 ,  A61K9/0065 ,  A61K9/20 ,  A61K31/167 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/402 ,  A61M2210/1085

    摘要： Implantable devices and methods for controlled drug delivery are provided. The device includes a device structure deformable between a retention shape and a low profile shape for deployment in the bladder of a patient and has a drug reservoir lumen in which a drug formulation is housed. The device also includes a buoyancy retention portion, which includes a volume of entrapped air or a gas-generating or effervescent powder which will generate a volume of entrapped air following contact with urine in the bladder. The buoyancy retention portion may include a water permeable and/or biodegradable wall, which can release the entrapped air following drug release, to cause the device to sink into the bladder neck to facilitate device expulsion without the need for a device retrieval medical procedure.

    摘要翻译： 提供了用于受控药物递送的可植入装置和方法。 该装置包括可在保持形状和低轮廓形状之间变形的装置结构，用于展开在患者的膀胱中，并且具有容纳药物制剂的药物储存器腔。 该装置还包括浮力保持部分，其包括一定量的夹带的空气或气体产生或泡腾的粉末，其将在与膀胱中的尿液接触之后产生一定量的夹带的空气。 浮力保持部分可以包括水可渗透的和/或可生物降解的壁，其可以在药物释放之后释放夹带的空气，以使得装置沉入膀胱颈部以促进装置排出而不需要装置取回医学程序。

    IMPLANTABLE DEVICE FOR CONTROLLED DISSOLUTION AND DIFFUSION OF LOW SOLUBILITY DRUG
    7.
    发明申请
    IMPLANTABLE DEVICE FOR CONTROLLED DISSOLUTION AND DIFFUSION OF LOW SOLUBILITY DRUG 有权
    用于控制溶解性和低溶解性药物扩散的可植入装置

    公开(公告)号：US20120203203A1

    公开(公告)日：2012-08-09

    申请号：US13366981

    申请日：2012-02-06

    申请人： Heejin Lee ,  Hong Linh Ho Duc ,  Matthew Sansone

    发明人： Heejin Lee ,  Hong Linh Ho Duc ,  Matthew Sansone

    IPC分类号： A61M31/00

    CPC分类号： A61K9/0024 ,  A61K9/0034 ,  A61K31/337 ,  A61K31/407 ,  A61K31/46 ,  A61K31/555 ,  A61K31/7064 ,  A61K33/24 ,  A61M31/002 ,  A61M37/0069 ,  A61M2210/1085 ,  A61M2210/1089

    摘要： Implantable drug delivery devices are provided that are deformable between a relatively straightened shape suitable for deployment and a retention shape suited to retain the device within the bladder or other body cavity. While in the body cavity, the devices release drug from solid drug units housed in the devices. The devices are designed to house the solid drug units in a way that exposes one or more sides of the solid drug units to the fluid at the in vivo site of deployment. Methods for using the devices for administering drug and making the devices also are provided.

    摘要翻译： 提供可植入药物递送装置，其可在适于展开的相对矫直形状和适于将装置保持在囊或其它体腔内的保持形状之间变形。 在体腔中，装置将药物从容纳在装置中的固体药物单元释放出来。 这些装置被设计成以固定药物单元的一侧或多侧将暴露在体内部位的液体的方式容纳固体药物单元。 还提供了使用用于给药的装置和制造装置的方法。