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1.发明授权Thiazol-2-yl-oxamic acid derivatives, and therapeutic agents containing these compounds 失效噻唑-2-基 - 恶唑酸衍生物和含有这些化合物的治疗剂
公开(公告)号：US4407810A
公开(公告)日：1983-10-04
申请号：US282661
申请日：1981-07-13
IPC分类号： C07D277/20 , A61K31/425 , A61K31/426 , A61P37/08 , C07D277/44 , C07D277/46
CPC分类号： C07D277/46
摘要： Novel 2-substituted thiazol-2-yl-oxamic acid esters, processes for their preparation, and therapeutic agents which contain these compounds and are useful in the treatment of allergic disorders.
摘要翻译： 新的2-取代的噻唑-2-基 - 恶唑酸酯，其制备方法和含有这些化合物并可用于治疗过敏性疾病的治疗剂。
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2.再颁专利6-(alkanolaminoaryl)-3(2H)-pyridazinone derivatives, and their use 失效6-（链烷醇氨基芳基）-3（2H） - 哒嗪酮衍生物及其用途
公开(公告)号：USRE33476E
公开(公告)日：1990-12-04
申请号：US189136
申请日：1988-05-02
申请人： Phillip A. Rossy , Marco Thyes , Albrecht Franke , Horst Koenig , Hans D. Lehmann , Josef Gries , Ludwig Friedrich , Dieter Lenke
发明人： Phillip A. Rossy , Marco Thyes , Albrecht Franke , Horst Koenig , Hans D. Lehmann , Josef Gries , Ludwig Friedrich , Dieter Lenke
IPC分类号： A61K31/50 , A61K31/502 , A61K31/535 , A61K31/55 , A61P1/04 , A61P7/02 , A61P9/12 , C07D237/04 , C07D237/14 , C07D237/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/14 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D237/04 , C07D237/14 , C07D237/26 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Novel 6-(acylaminoaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described.[.and inhibiting thrombocyte aggregation and gastric secretion.]..The compounds are useful for treating disorders .Iadd.and inhibiting thrombocyte aggregation and gastric secretion.Iaddend..
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3.发明授权Triazoloquinazolinones, and compositions and methods for treating allergic disorders with them 失效三唑并喹唑啉酮，以及用它们治疗过敏性疾病的组合物和方法
公开(公告)号：US4463007A
公开(公告)日：1984-07-31
申请号：US441805
申请日：1982-11-15
申请人： Rainer Schlecker , Ludwig Friedrich , Dieter Lenke
发明人： Rainer Schlecker , Ludwig Friedrich , Dieter Lenke
IPC分类号： A61K31/505 , A61P37/08 , C07D239/95 , C07D487/04 , C07D491/04 , C07D491/14 , C07D491/147
CPC分类号： C07D487/04 , C07D239/95 , C07D491/04 , C07D491/14
摘要： 1,2,4-Triazolo[1,5-c]-quinazolinones of the general formula I ##STR1## and their pharmaceutically tolerated salts, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful drugs in the treatment of allergic disorders.
摘要翻译： 具有通式I（I）的1,2,4-三唑并[1,5-c] - 喹唑啉酮及其药学上可耐受的盐，其制备方法和含有这些化合物的药物制剂，并且是其中有用的药物 治疗过敏性疾病。
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4.发明授权Gastric acid secretion inhibiting N-(imidazol-1-ylalkyl)thiourea derivatives 失效抑制N-（咪唑-1-基烷基）硫脲衍生物的胃酸分泌
公开(公告)号：US4514413A
公开(公告)日：1985-04-30
申请号：US482790
申请日：1983-04-07
申请人： Bernd Ostersehlt , Albrecht Franke , Fritz-Frieder Frickel , Marco Thyes , Ludwig Friedrich , Josef Gries , Dieter Lenke
发明人： Bernd Ostersehlt , Albrecht Franke , Fritz-Frieder Frickel , Marco Thyes , Ludwig Friedrich , Josef Gries , Dieter Lenke
IPC分类号： C07D405/12 , A61K31/415 , A61P1/04 , A61P43/00 , C07D233/61 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： N-substituted imidazole derivatives of the formula I ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are identical or different and are each hydrogen or alkyl with 1 or 3 carbon atoms and Alk is an alkylene chain of 2 to 4 carbon atoms, and their salts with physiologically tolerated acids, processes for their preparation, drugs containing a compound of the formula I or one of its salts, and their use for treating disorders associated with gastric hyperacidity.
摘要翻译： 其中R 1，R 2和R 3相同或不同并且各自为氢或具有1或3个碳原子的烷基，Alk为2至4个碳原子的亚烷基链的式I的N-取代的咪唑衍生物 原子及其盐与生理学耐受的酸，其制备方法，含有式I化合物或其盐的药物及其用于治疗与胃酸过多相关的疾病的用途。
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5.发明授权5,6-Dihydro-11-methylenemorphanthridin-6-ones, their preparation and drugs containing these compounds 失效5,6-二氢-11-亚甲基呋喃-6-酮，其制备方法和含有这些化合物的药物
公开(公告)号：US4477451A
公开(公告)日：1984-10-16
申请号：US482004
申请日：1983-04-05
申请人： Gerd Steiner , Ludwig Friedrich , Dieter Lenke
发明人： Gerd Steiner , Ludwig Friedrich , Dieter Lenke
IPC分类号： A61K31/55 , A61P1/04 , C07D223/20 , C07D403/06
CPC分类号： C07D223/20 , Y10S514/926
摘要： 5,6-Dihydro-11-methylenemorphanthridin-6-ones of the formula I ##STR1## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meanings given in the description, and their preparation and use.The novel substances are particularly useful for treating gastric and duodenal ulcers.
摘要翻译： 其中R 1，R 2，R 3和R 4具有本说明书中给出的含义及其制备和用途的式I的化合物5,6-二氢-11-亚甲基大戟素-6-酮。 新型物质特别适用于治疗胃十二指肠溃疡。
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6.发明授权5,6-Dihydro-11-alkylene-morphanthridin-6-ones, their pharmaceutical compositions and method of use 失效5,6-二氢-11-亚烷基 - 异佛尔酮-6-酮，其药物组合物和使用方法
公开(公告)号：US4399139A
公开(公告)日：1983-08-16
申请号：US359936
申请日：1982-03-19
申请人： Gerd Steiner , Ludwig Friedrich , Dieter Lenke
发明人： Gerd Steiner , Ludwig Friedrich , Dieter Lenke
IPC分类号： A61K31/00 , A61K31/55 , A61P1/04 , C07D223/20 , C07F9/59 , C07D403/06
CPC分类号： C07F9/591 , C07D223/20 , Y10S514/926
摘要： Novel 5,6-dihydro-11-alkylene-morphanthridin-6-ones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meanings given in the description, their preparation and their use.The novel compounds are particularly useful in the treatment of gastric and duodenal ulcers.
摘要翻译： 其中R 1，R 2，R 3和R 4具有本说明书中给出的含义及其制备方法及其用途的新颖的5,6-二氢-11-亚烷基 - 异恶唑-6-酮。 新型化合物特别可用于治疗胃和十二指肠溃疡。
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7.发明授权
公开(公告)号：US4873246A
公开(公告)日：1989-10-10
申请号：US916843
申请日：1986-10-08
申请人： Philip A. Rossy , Marco Thyes , Albrecht Franke , Horst Koenig , Hans D. Lehmann , Josef Gries , Ludwig Friedrich , Dieter Lenke
发明人： Philip A. Rossy , Marco Thyes , Albrecht Franke , Horst Koenig , Hans D. Lehmann , Josef Gries , Ludwig Friedrich , Dieter Lenke
IPC分类号： A61K31/50 , A61K31/502 , A61K31/535 , A61K31/55 , A61P1/04 , A61P7/02 , A61P9/12 , C07D237/04 , C07D237/14 , C07D237/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/14 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D237/04 , C07D237/14 , C07D237/26 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Novel 6-(acylaminaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described.The compounds have thrombocyte aggregation-inhibiting activity.
摘要翻译： 其中R 1，R 2，R 3，R 4，A和B具有本说明书中给出的含义的新颖的6-（酰基氨基芳基）-3（2H） - 哒嗪酮及其制备。 该化合物具有血细胞聚集抑制活性。
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8.发明授权
公开(公告)号：US4636504A
公开(公告)日：1987-01-13
申请号：US571675
申请日：1984-01-17
申请人： Phillip A. Rossy , Marco Thyes , Albrecht Franke , Horst Koenig , Hans Dieter Lehmann , Josef Gries , Ludwig Friedrich , Dieter Lenke
发明人： Phillip A. Rossy , Marco Thyes , Albrecht Franke , Horst Koenig , Hans Dieter Lehmann , Josef Gries , Ludwig Friedrich , Dieter Lenke
IPC分类号： A61K31/50 , A61K31/502 , A61K31/535 , A61K31/55 , A61P1/04 , A61P7/02 , A61P9/12 , C07D237/04 , C07D237/14 , C07D237/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/14 , C07D521/00 , C07D237/06
CPC分类号： C07D231/12 , C07D233/56 , C07D237/04 , C07D237/14 , C07D237/26 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Novel 6-(acylaminoaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described and inhibiting thrombocyte aggregation and gastric secretion.The compounds are useful for treating disorders.
摘要翻译： 式（Ⅰ）的新型6-（酰基氨基芳基）-3（2H） - 哒嗪酮其中R 1，R 2，R 3，R 4，A和B具有说明书中给出的含义及其制备，并描述并抑制血小板 聚集和胃分泌。 该化合物可用于治疗疾病。
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9.发明授权Tricyclic thiazolyloxamic acids and their derivatives, their preparation, and therapeutic agents containing these compounds 失效三环噻唑氧酸及其衍生物，其制备方法和含有这些化合物的治疗剂
公开(公告)号：US4517196A
公开(公告)日：1985-05-14
申请号：US411612
申请日：1982-08-26
申请人： Rainer Schlecker , Ludwig Friedrich , Dieter Lenke
发明人： Rainer Schlecker , Ludwig Friedrich , Dieter Lenke
IPC分类号： A61K31/425 , A61K31/428 , A61P37/08 , C07D277/60 , C07D277/84
CPC分类号： C07D277/60 , C07D277/84
摘要： Thiazolyloxamic acids and their derivatives of the general formula I ##STR1## processes for their preparation, and pharmaceutical formulations which contain these compounds and are useful as drugs for treating allergic disorders.
摘要翻译： 通式Ⅰ“IMAGE”的噻唑基氧基酸及其衍生物的制备方法以及含有这些化合物并可用作治疗过敏性疾病的药物的药物制剂。
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10.发明授权Aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones, their preparation and therapeutic agents containing these compounds 失效2-羟基-β-苯基 - 苯丙酮的氨基丙醇衍生物，它们的制备和含有这些化合物的治疗剂
公开(公告)号：US4571409A
公开(公告)日：1986-02-18
申请号：US733631
申请日：1985-05-13
申请人： Albrecht Franke , Josef Mueller , Helmut Lietz , Walter-Wielant Wiersdorff , Hans-Guenther Hege , Claus D. Mueller , Josef Gries , Dieter Lenke , Gerda von Philipsborn , Manfred Raschack
发明人： Albrecht Franke , Josef Mueller , Helmut Lietz , Walter-Wielant Wiersdorff , Hans-Guenther Hege , Claus D. Mueller , Josef Gries , Dieter Lenke , Gerda von Philipsborn , Manfred Raschack
IPC分类号： C07C45/62 , C07C45/71 , C07C45/73 , C07C45/74 , C07C49/83 , C07C49/835 , C07C49/84 , C07D211/46 , C07D211/52 , C07D295/092 , C07D303/22 , C07D303/24 , A61K31/135 , C07C97/10
CPC分类号： C07D295/088 , C07C45/62 , C07C45/71 , C07C45/73 , C07C45/74 , C07C49/83 , C07C49/835 , C07C49/84 , C07D211/46 , C07D211/52 , C07D303/22 , C07D303/24
摘要： Novel aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.
摘要翻译： 2-羟基-β-苯基 - 苯丙酮的新型氨基丙醇衍生物及其生理上可接受的酸加成化合物，其制备方法和含有这些衍生物的治疗剂，可用作抗心律失常药物。
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