公开(公告)号：US20100094316A1

公开(公告)日：2010-04-15

申请号：US12448110

申请日：2007-12-10

申请人： Heinz Rupp ,  Bernhard Maisch ,  Thomas Philipp Rupp ,  Ekkehard Schüler ,  Karin Rupp

发明人： Heinz Rupp ,  Bernhard Maisch ,  Thomas Philipp Rupp ,  Ekkehard Schüler ,  Karin Rupp

IPC分类号： A61B17/08

CPC分类号： A61B17/3478 ,  A61B17/320016 ,  A61B2017/00243 ,  A61B2017/00269 ,  A61B2017/306

摘要： The invention concerns a device for the fixation and manipulation of those tissues which are at least temporarily suitable for being fixed by suction.Hereby, tissues are understood to be, in addition to organic tissues, such as e.g. tissues of animals and humans, also inorganic tissues, such as films or textiles.In particular, the invention concerns a device for the fixation and manipulation of tissues which surround sensitive organs, such as e.g. the pericardium in humans.Furthermore, the invention concerns a method for the fixation and manipulation and, in particular, for puncturing of such tissues or the underlying areas.

摘要翻译： 本发明涉及用于固定和操纵那些至少临时适于通过抽吸固定的那些组织的装置。 因此，除了有机组织之外，组织也被理解为是例如。 动物和人类的组织，以及无机组织，例如膜或纺织品。 特别地，本发明涉及用于固定和操纵围绕敏感器官的组织的装置，例如， 人心包膜。 此外，本发明涉及一种用于固定和操纵的方法，特别涉及用于刺穿这些组织或下面区域的方法。

公开(公告)号：US20100016663A1

公开(公告)日：2010-01-21

申请号：US12085464

申请日：2006-11-30

申请人： Bernhard Maisch ,  Heinz Rupp ,  Thomas Philipp Rupp

发明人： Bernhard Maisch ,  Heinz Rupp ,  Thomas Philipp Rupp

IPC分类号： A61B1/01

CPC分类号： A61B1/01 ,  A61B1/00087 ,  A61B1/0051

摘要： The invention relates to an arrangement which can be fixed to the inside of a cavity by means of fixing means which are associated with said arrangement. Said fixing means fix the arrangement in relation to at least one part of the wall of the cavity which is to be examined, wherein the arrangement must at least partially be inserted. Said arrangement enables the instruments, which are used to examine/manipulate cavities, even when the arrangement and/or the instrument is displaced in a translatory and/or rotational manner, in particular, in angled cavities, to be guided in a reliable manner.

摘要翻译： 本发明涉及一种能够通过与所述装置相关联的固定装置固定到空腔内部的装置。 所述固定装置相对于待检查的腔的壁的至少一部分固定该装置，其中该装置必须至少部分地被插入。 所述布置使得即使当布置和/或器械以平移和/或旋转方式（特别是在成角度的空腔中）移动以便以可靠的方式被引导时，用于检查/操纵空腔的器械也是可以的。

公开(公告)号：US07309706B2

公开(公告)日：2007-12-18

申请号：US11013326

申请日：2004-12-17

申请人： Heinz Rupp ,  Bernd Eisele ,  Dieter Ziegler ,  Bodo Jaeger ,  Bernhard Maisch

发明人： Heinz Rupp ,  Bernd Eisele ,  Dieter Ziegler ,  Bodo Jaeger ,  Bernhard Maisch

IPC分类号： A61K31/513 ,  A61K31/498

CPC分类号： A61K31/4178 ,  A61K31/421 ,  A61K31/47 ,  A61K31/496 ,  A61K31/506

摘要： The use of selective imidazoline receptor agonists, such as moxonidine, rilmenidine, LNP-509, S-23515, PMS-812, PMS-847 and BU-98008, and their physiologically compatible acid addition salts in pharmaceutical preparations for the treatment and/or inhibition of functional disorders and/or diseases in larger mammals or humans which require inhibition or reduction of the activity of proteins which regulate the intracellular pH value and which belong to the superfamily of bicarbonate transporters, in particular the treatment or inhibition of clinical conditions of bones which are caused by an undesirable amount of bone resorption, such as osteoporosis; of diseases of the gastrointestinal tract, such as gastric ulcers; and of neuronal and/or neuropsychiatric diseases associated with a pathologically altered (especially increased) neuronal activity, such as depression, Alzheimer's disease, eating disorders and schizophrenia.

摘要翻译： 在药物制剂中使用选择性咪唑啉受体激动剂如莫索尼定，利妥替尼，LNP-509，S-23515，PMS-812，PMS-847和BU-98008及其生理上相容的酸加成盐用于治疗和/或 需要抑制或降低调节细胞内pH值的蛋白质的活性并且属于碳酸氢盐转运蛋白超家族的大型哺乳动物或人类的功能障碍和/或疾病的抑制，特别是治疗或抑制骨骼临床状况 其由不期望的骨吸收量例如骨质疏松引起; 的胃肠道疾病，如胃溃疡; 以及与病理改变（特别是增加的）神经元活动相关的神经元和/或神经精神疾病，例如抑郁症，阿尔茨海默病，进食障碍和精神分裂症。

公开(公告)号：US20070198041A1

公开(公告)日：2007-08-23

申请号：US10568430

申请日：2004-08-12

申请人： Heinz Rupp ,  Bernhard Maisch ,  Ekkehard Schuler ,  Michael Koch

发明人： Heinz Rupp ,  Bernhard Maisch ,  Ekkehard Schuler ,  Michael Koch

IPC分类号： A61B17/32

CPC分类号： A61B17/3478 ,  A61B2017/00243 ,  A61B2017/00269 ,  A61B2017/00473 ,  A61B2017/306 ,  A61B2090/064 ,  A61B2090/373 ,  A61B2090/378 ,  A61N1/0587

摘要： The invention relates to apparatus puncturing, or manipulating in some other way, human or animal tissues, tissue attachment being reliably detected and communicated. In particular the apparatus of the invention allows accessing the cardiac sac after the pericardium has been pierced. The apparatus of the invention is applicable to any human or animal or organ tissue, foremost within the scope of minimally invasive surgery lacking direct visual monitoring and where it is necessary to make sure that tissue/organs be attached for purposes of manipulation, in particular puncturing, to a special, for instance puncturing apparatus. The invention is not restricted to living tissue/organs.

摘要翻译： 本发明涉及设备穿刺或以某种其他方式操纵人或动物组织，可靠地检测和传达组织附着。 特别地，本发明的装置允许在心包穿刺后进入心囊。 本发明的装置可应用于任何人或动物或器官组织，其首先在微创手术的范围内，其缺乏直接的视觉监测，并且在需要确保组织/器官被附着以用于操作，特别是穿刺 到一个特殊的例如穿刺装置。 本发明不限于活体组织/器官。

公开(公告)号：US20050165080A1

公开(公告)日：2005-07-28

申请号：US11013326

申请日：2004-12-17

申请人： Heinz Rupp ,  Bernd Eisele ,  Dieter Ziegler ,  Bodo Jaeger ,  Bernhard Maisch

发明人： Heinz Rupp ,  Bernd Eisele ,  Dieter Ziegler ,  Bodo Jaeger ,  Bernhard Maisch

IPC分类号： A61K31/4178 ,  A61K31/421 ,  A61K31/47 ,  A61K31/496 ,  A61K31/506 ,  A61P1/00 ,  A61P19/00 ,  A61P25/00

CPC分类号： A61K31/4178 ,  A61K31/421 ,  A61K31/47 ,  A61K31/496 ,  A61K31/506

摘要： The use of selective imidazoline receptor agonists, such as moxonidine, rilmenidine, LNP-509, S-23515, PMS-812, PMS-847 and BU-98008, and their physiologically compatible acid addition salts in pharmaceutical preparations for the treatment and/or inhibition of functional disorders and/or diseases in larger mammals or humans which require inhibition or reduction of the activity of proteins which regulate the intracellular pH value and which belong to the superfamily of bicarbonate transporters, in particular the treatment or inhibition of clinical conditions of bones which are caused by an undesirable amount of bone resorption, such as osteoporosis; of diseases of the gastrointestinal tract, such as gastric ulcers; and of neuronal and/or neuropsychiatric diseases associated with a pathologically altered (especially increased) neuronal activity, such as depression, Alzheimer's disease, eating disorders and schizophrenia.

摘要翻译： 在药物制剂中使用选择性咪唑啉受体激动剂如莫索尼定，利妥替尼，LNP-509，S-23515，PMS-812，PMS-847和BU-98008及其生理上相容的酸加成盐用于治疗和/或 需要抑制或降低调节细胞内pH值的蛋白质的活性并且属于碳酸氢盐转运蛋白超家族的大型哺乳动物或人类的功能障碍和/或疾病的抑制，特别是治疗或抑制骨骼临床状况 其由不期望的骨吸收量例如骨质疏松引起; 的胃肠道疾病，如胃溃疡; 以及与病理改变（特别是增加的）神经元活动相关的神经元和/或神经精神疾病，例如抑郁症，阿尔茨海默病，进食障碍和精神分裂症。