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    Fluorine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
    3.
    发明授权
    Fluorine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases 失效
    氟取代的联苯丁酸及其衍生物作为基质金属蛋白酶的抑制剂

    公开(公告)号：US06169103A

    公开(公告)日：2001-01-02

    申请号：US09256714

    申请日：1999-02-24

    申请人： Claude Forsey Purchase, Jr. ,  Bruce David Roth ,  Gerald Paul Schielke ,  Lary Craswell Walker ,  Andrew David White

    发明人： Claude Forsey Purchase, Jr. ,  Bruce David Roth ,  Gerald Paul Schielke ,  Lary Craswell Walker ,  Andrew David White

    IPC分类号： A61K3140

    CPC分类号： C07C327/58 ,  A61K31/275 ,  A61K31/40 ,  C07C251/48 ,  C07C255/64

    摘要： Fluorine-substituted biphenyl butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, stromelysin-1, and collagenase-3, and for the treatment of atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, osteoporosis, multiple sclerosis, renal disease, and other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.

    摘要翻译： 描述了氟取代的联苯基丁酸化合物和衍生物以及用于制备的酸法和其药物组合物，其可用作基质金属蛋白酶抑制剂，特别是明胶酶A，溶基质溶质素-1和胶原酶-3，并且对于 治疗动脉粥样硬化斑块破裂，主动脉瘤，心力衰竭，再狭窄，牙周病，角膜溃疡，烧伤治疗，褥疮溃疡，伤口愈合，癌症，炎症，疼痛，关节炎，骨质疏松症，多发性硬化，肾脏疾病和其他自身免疫或 依赖于白细胞或其他活化的迁移细胞的组织侵袭的炎性病症，急性和慢性神经变性疾病，包括中风，头部创伤，脊髓损伤，阿尔茨海默病，肌萎缩性侧索硬化，脑淀粉样血管病，艾滋病，帕金森病，亨廷顿病，朊病毒疾病 ，重症肌无力和Duchenne的肌营养不良症。

    Benzene butyric acids and their derivatives as inhibitors of matrix metalloproteinases
    5.
    发明授权
    Benzene butyric acids and their derivatives as inhibitors of matrix metalloproteinases 失效
    苯丁酸及其衍生物作为基质金属蛋白酶的抑制剂

    公开(公告)号：US06541521B1

    公开(公告)日：2003-04-01

    申请号：US09351549

    申请日：1999-07-12

    申请人： Claude Forsey Purchase, Jr. ,  Bruce David Roth ,  Andrew David White

    发明人： Claude Forsey Purchase, Jr. ,  Bruce David Roth ,  Andrew David White

    IPC分类号： A61K31195

    CPC分类号： C07D213/82 ,  C07C233/54 ,  C07C233/55 ,  C07C233/63 ,  C07C233/81 ,  C07C235/56 ,  C07C251/48 ,  C07C2601/14 ,  C07D333/38

    摘要： Benzene butyric acid compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurysm, heart failure, left ventricular dilation, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, osteoporosis, renal disease, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.

    摘要翻译： 苯丁酸化合物和衍生物以及其制备方法及其药物组合物的描述，其可用作基质金属蛋白酶抑制剂，特别是明胶酶A，胶原酶-3和溶基质溶解素-1以及用于治疗多发性硬化， 动脉粥样硬化斑块破裂，主动脉瘤，心力衰竭，左心室扩张，再狭窄，牙周病，角膜溃疡，烧伤治疗，褥疮溃疡，伤口愈合，癌症，炎症，疼痛，关节炎，骨质疏松症，肾脏疾病或其他自身免疫或炎症 依赖于白细胞或其他激活的迁移细胞的组织侵袭的疾病，急性和慢性神经变性疾病，包括中风，头部创伤，脊髓损伤，阿尔茨海默病，肌萎缩性侧索硬化，脑淀粉样血管病，艾滋病，帕金森病，亨廷顿病，朊病毒疾病， 重症肌无力和Duchenne肌营养不良症。

    Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
    7.
    发明授权
    Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases 失效
    杂芳基丁酸及其衍生物作为基质金属蛋白酶的抑制剂

    公开(公告)号：US06399612B1

    公开(公告)日：2002-06-04

    申请号：US09647400

    申请日：2000-10-23

    申请人： Claude Forsey Purchase, Jr. ,  Bruce David Roth ,  Gerald Paul Schielke ,  Lary Craswell Walker ,  Andrew David White

    发明人： Claude Forsey Purchase, Jr. ,  Bruce David Roth ,  Gerald Paul Schielke ,  Lary Craswell Walker ,  Andrew David White

    IPC分类号： A61K31495

    CPC分类号： C07D231/12 ,  C07D333/28

    摘要： Heteroaryl butyric acid compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, osteoporosis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.

    摘要翻译： 描述了杂芳基丁酸化合物和衍生物以及其制备方法及其药物组合物，其可用作基质金属蛋白酶抑制剂，特别是明胶酶A，胶原酶-3和溶基质蛋白溶解素-1以及用于治疗多发性硬化， 动脉粥样硬化斑块破裂，主动脉瘤，心力衰竭，再狭窄，牙周病，角膜溃疡，烧伤治疗，褥疮性溃疡，伤口愈合，癌症，炎症，疼痛，关节炎，骨质疏松症或依赖于白细胞组织侵袭的其他自身免疫性或炎症性疾病 或其他活化的迁移细胞，急性和慢性神经变性疾病，包括中风，头部创伤，脊髓损伤，阿尔茨海默病，肌萎缩性侧索硬化，脑淀粉样血管病，艾滋病，帕金森病，亨廷顿病，朊病毒疾病，重症肌无力和杜氏肌营养不良症 。

    Flourine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
    8.
    发明授权
    Flourine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases 失效
    氟取代的联苯丁酸及其衍生物作为基质金属蛋白酶的抑制剂

    公开(公告)号：US06265432B1

    公开(公告)日：2001-07-24

    申请号：US09503235

    申请日：2000-02-11

    申请人： Claude Forsey Purchase, Jr. ,  Bruce David Roth ,  Gerald Paul Schielke ,  Lary Craswell Walker ,  Andrew David White

    发明人： Claude Forsey Purchase, Jr. ,  Bruce David Roth ,  Gerald Paul Schielke ,  Lary Craswell Walker ,  Andrew David White

    IPC分类号： A61K3140

    CPC分类号： C07C327/58 ,  A61K31/275 ,  A61K31/40 ,  C07C251/48 ,  C07C255/64

    摘要： Fluorine-substituted biphenyl butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, stromelysin-1, and collagenase-3, and for the treatment of atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of bums, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, osteoporosis, multiple sclerosis, renal disease, and other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.

    摘要翻译： 描述了氟取代的联苯基丁酸化合物和衍生物以及用于制备的酸法和其药物组合物，其可用作基质金属蛋白酶抑制剂，特别是明胶酶A，溶基质溶质素-1和胶原酶-3，并且对于 治疗动脉粥样硬化斑块破裂，主动脉瘤，心力衰竭，再狭窄，牙周病，角膜溃疡，烧伤治疗，褥疮溃疡，伤口愈合，癌症，炎症，疼痛，关节炎，骨质疏松症，多发性硬化，肾脏疾病和其他自身免疫或 依赖于白细胞或其他活化的迁移细胞的组织侵袭的炎性病症，急性和慢性神经变性疾病，包括中风，头部创伤，脊髓损伤，阿尔茨海默病，肌萎缩性侧索硬化，脑淀粉样血管病，艾滋病，帕金森病，亨廷顿病，朊病毒疾病 ，重症肌无力和Duchenne的肌营养不良症。

    Biphenyl hydroxy imino butyric acids and their derivatives for treating arthritis
    9.
    发明授权
    Biphenyl hydroxy imino butyric acids and their derivatives for treating arthritis 失效
    联苯羟基亚氨基丁酸及其衍生物用于治疗关节炎

    公开(公告)号：US06239288B1

    公开(公告)日：2001-05-29

    申请号：US09254231

    申请日：1999-03-02

    申请人： Claude Forsey Purchase, Jr. ,  Bruce David Roth ,  Gerald Paul Schielke ,  Lary Craswell Walker ,  Andrew David White

    发明人： Claude Forsey Purchase, Jr. ,  Bruce David Roth ,  Gerald Paul Schielke ,  Lary Craswell Walker ,  Andrew David White

    IPC分类号： C07D20904

    CPC分类号： C07C323/63 ,  C07C59/56 ,  C07C59/84 ,  C07C59/88 ,  C07C59/90 ,  C07C69/738 ,  C07C251/48 ,  C07C251/86 ,  C07C255/64

    摘要： Biphenyl butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of bums, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.

    摘要翻译： 描述了联苯丁酸化合物和衍生物以及用于制备的酸法和其药物组合物，其可用作基质金属蛋白酶抑制剂，特别是明胶酶A（72kD明胶酶）和基质溶素-1和用于治疗多发性硬化症 ，动脉粥样硬化斑块破裂，主动脉瘤，心力衰竭，再狭窄，牙周病，角膜溃疡，治疗烧伤，褥疮溃疡，伤口愈合，癌症，炎症，疼痛，关节炎或依赖于白细胞组织侵袭的其他自身免疫性或炎症性疾病或 其他活化的迁移细胞，急性和慢性神经变性疾病，包括中风，头部创伤，脊髓损伤，阿尔茨海默病，肌萎缩性侧索硬化，脑淀粉样血管病，艾滋病，帕金森病，亨廷顿病，朊病毒疾病，重症肌无力和杜氏肌营养不良症。