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公开(公告)号：US5606054A
公开(公告)日：1997-02-25
申请号：US166440
申请日：1993-12-14
IPC分类号： C07D471/04 , C07D487/04 , C07D495/04 , A61K31/55
CPC分类号： C07D471/04 , C07D487/04 , C07D495/04
摘要： There are disclosed certain novel compounds identified as heterocyclic-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such heterocyclic-fused lactams as the active ingredient thereof are also disclosed.
摘要翻译： 公开了鉴定为杂环稠合内酰胺的某些新化合物，其促进人和动物中生长激素的释放。 该物质可用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人体中，增加受缺乏正常分泌天然生长激素影响的人的身高。 还公开了含有这样的杂环稠合内酰胺作为其活性成分的生长促进组合物。
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公开(公告)号：US5789587A
公开(公告)日：1998-08-04
申请号：US744296
申请日：1996-11-06
IPC分类号： C07D471/04 , C07D487/04 , C07D495/04 , A61K31/55
CPC分类号： C07D471/04 , C07D487/04 , C07D495/04
摘要： There are disclosed certain novel compounds identified as heterocyclic-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such heterocyclic-fused lactams as the active ingredient thereof are also disclosed.
摘要翻译： 公开了鉴定为杂环稠合内酰胺的某些新化合物，其促进人和动物中生长激素的释放。 该物质可用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人体中，增加受缺乏正常分泌天然生长激素影响的人的身高。 还公开了含有这样的杂环稠合内酰胺作为其活性成分的生长促进组合物。
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公开(公告)号：US5830875A
公开(公告)日：1998-11-03
申请号：US429919
申请日：1989-10-30
申请人： Helmut Mrozik , Thomas L. Shih
发明人： Helmut Mrozik , Thomas L. Shih
IPC分类号： C12P17/18 , A01N43/90 , A61K31/365 , A61K31/70 , A61P33/10 , C07D493/22 , C07F7/18 , C07H19/01 , C12R1/465 , A61K31/335 , C07H17/08 , C07D300/00
CPC分类号： C07H19/01
摘要： Novel avermectin and milbemycin derivatives are disclosed, where the C-24 and C-25 carbon atoms are substituted by hydrogen, alkyl, alkenyl, substituted alkyl or substituted alkenyl groups. These compounds can be further substituted at the 4"-, 5-, 13-, and 23-positions. The new C-24 and C-25 substituted avermect prepared by cleavage of known and suitably protected avermectin and milbemycin compounds. The new compounds are potent anti-parasitic agents, in particular, the compounds are anthelmintic, insecticidal and acaricidal agents.
摘要翻译： 公开了新的除虫菌素和米尔倍霉素衍生物，其中C-24和C-25碳原子被氢，烷基，烯基，取代的烷基或取代的烯基取代。 这些化合物可以在4“，5”，“13”和“23”位进一步取代。 通过裂解已知和适当保护的阿维菌素和米尔倍霉素化合物制备的新C-24和C-25取代的除虫剂。 新化合物是有效的抗寄生虫剂，特别是化合物是驱肠虫，杀虫剂和杀螨剂。
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公开(公告)号：US4831016A
公开(公告)日：1989-05-16
申请号：US925772
申请日：1986-10-31
申请人： Helmut Mrozik , Thomas L. Shih
发明人： Helmut Mrozik , Thomas L. Shih
IPC分类号： C07D493/22 , A01N43/90 , A01N47/18 , A01N47/24 , A01N47/34 , A01N51/00 , A01N55/00 , A23K1/16 , A23K1/17 , A61K31/365 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P33/00 , A61P33/10 , C07F7/18 , C07H17/08 , C07H19/01
CPC分类号： C07H19/01 , A01N43/90 , A23K20/195
摘要： There are disclosed novel avermectin reduction products. The compounds are prepared by selective catalytic hydrogenation of avermectin-like compounds or by reaction of selected double bonds with electrophylic reagents. The reduced avermectin compounds have utility as anti-parasitic agents and compositions for that use are also disclosed. The compounds are also highly potent insecticides against agricultural pests. The reduced avermectin compounds have increased stability towards light which prolongs their insecticidal activities when applied to field crops subject to irradiation by sunlight.
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公开(公告)号：US4906619A
公开(公告)日：1990-03-06
申请号：US222868
申请日：1988-07-22
申请人： Philip Eskola , Thomas L. Shih , Helmut Mrozik
发明人： Philip Eskola , Thomas L. Shih , Helmut Mrozik
IPC分类号： C07H17/08 , A01N43/90 , A61K31/365 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P33/10 , C07D493/22 , C07H19/01
摘要： There are disclosed avermectin derivatives with a hydroxy and hydrocarbon substituents at the 5, 10, 13, 23, 4' and 4" positions which are prepared by the reaction of the 5, 10, 13, 23, 4' or 4" ketone compound with an organo-metallic Grignard reagent. The compounds are potent antiparasitic and anthelmintic agents in human and animal therapy and are potent pesticidical agents against agricultural pests. Compositions containing such compounds as the active agent are also disclosed.
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公开(公告)号：US5411946A
公开(公告)日：1995-05-02
申请号：US21450
申请日：1993-02-24
申请人： Ronald C. Newbold , Thomas L. Shih
发明人： Ronald C. Newbold , Thomas L. Shih
CPC分类号： C07H19/01
摘要： Avermectin derivatives, wherein the C-17-21-25-dioxaspirane substructure has been modified to include substitutions of heteratomic nucleophilic thiols at the 23,24-.alpha.-epoxide. These compounds can be similarly substituted at the 4"-, 5-, 13, and 25-positions. The new C-23 and C-24 substituted avermectin derivatives are potent anthelmintic, insecticidal and acaricidal agents.
摘要翻译： 阿维菌素衍生物，其中C-17-21-25-二氧戊环亚结构已经被修饰为包括在23,24-α-环氧化物上的杂原子亲核硫醇的取代。 这些化合物可以在4“，5”，“13”和“25”位置被类似地取代。 新的C-23和C-24取代的阿维菌素衍生物是有效的驱虫剂，杀虫剂和杀螨剂。
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公开(公告)号：US06221894B1
公开(公告)日：2001-04-24
申请号：US09269010
申请日：1999-03-17
IPC分类号： A61K31403
CPC分类号： A01N43/90 , A01N47/12 , A01N47/16 , A01N47/18 , A01N47/28 , A01N47/38 , A01N47/40 , A01N49/00 , A61K31/405 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/505 , A61K31/70 , C07D491/14 , A61K2300/00
摘要： The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.
摘要翻译： 本发明涉及杀螨，抗寄生虫，杀虫剂和驱肠虫剂的新型节肢动物酸衍生物。
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