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公开(公告)号：US20080113015A1
公开(公告)日：2008-05-15
申请号：US11569514
申请日：2005-05-24
IPC分类号： A61K9/127 , A61K38/16 , A61K31/715 , A61P43/00
CPC分类号： A61K9/1271
摘要： The present invention relates to liposomes for drug delivery, wherein a liposome includes molecules of at least one desired drug distributed within an aqueous phase in the interior of the liposome and wherein the liposome further includes molecules of the same or of another drug attached to either or both sides of the liposomal membrane. More specifically, the invention relates to liposomes, wherein at least a part of the molecules of a desired drug bear a functional group that is reactive with a functional group present in at least one lipid fraction, and wherein the drug is covalently linked to the membrane lipids by chemical bonding, e.g. by ester bonding of a hydroxyl group of a lipid molecule and an acidic residue of the drug. In a preferred embodiment, the desired drug is a glycoprotein such as erythropoietin. The invention further relates to a method of manufacture of said liposomes and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及用于药物递送的脂质体，其中脂质体包括分布在脂质体内部的水相内的至少一种所需药物的分子，并且其中所述脂质体还包括与所述脂质体或其它药物相连接的分子， 脂质体膜两侧。 更具体地，本发明涉及脂质体，其中所需药物的至少一部分分子具有与存在于至少一种脂质部分中的官能团反应的官能团，并且其中所述药物与膜共价连接 脂质通过化学键合，例如 通过脂质分子的羟基和药物的酸性残基的酯键合。 在优选的实施方案中，所需药物是糖蛋白，例如红细胞生成素。 本发明还涉及制备所述脂质体的方法和含有它们的药物组合物。
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2.发明授权Liposomal composition comprising an active ingredient for relaxing smooth muscle, the production of this composition and the therapeutic use thereof 有权包含用于松弛平滑肌的活性成分的脂质体组合物，该组合物的制备及其治疗用途公开(公告)号：US08524274B2
公开(公告)日：2013-09-03
申请号：US11577488
申请日：2005-10-14
CPC分类号： A61K9/127 , A61K9/0034 , A61K9/06 , A61K9/1277 , A61K9/1278
摘要： The invention relates to a pharmaceutical composition made from an active ingredient included in liposomes for topical application, whereby the liposomes have an aqueous medium in the interior thereof and contain at least one active ingredient therein which exerts a direct or indirect relaxing effect on smooth musculature and is preferably selected from the group of prostaglandins, adenylate cyclases, cAMP, AMP, ATP, NO-synthetases, nitrogen monoxide (NO), NO compounds, nitrates, guanylate cyclases, cGMP, GMP, GTP and phosphodiesterases, in particular, Sildenafil. The invention further relates to a method for production of said composition, optionally, in sterile form and the use of the liposomes supporting the active ingredient in various galenic forms for external application in the genital region, for prophylaxis and/or therapy of sexual disorders in men or women and/or for increase of sexual sensitivity.
摘要翻译： 本发明涉及由用于局部应用的脂质体中包含的活性成分制成的药物组合物，其中所述脂质体在其内部具有水性介质并且含有其中的至少一种活性成分，其对平滑肌肉组织施加直接或间接的缓解作用， 优选选自前列腺素，腺苷酸环化酶，cAMP，AMP，ATP，NO-合成酶，一氧化氮（NO），NO化合物，硝酸盐，鸟苷酸环化酶，cGMP，GMP，GTP和磷酸二酯酶，特别是西地那非。 本发明进一步涉及用于生产所述组合物的方法，任选地以无菌形式，以及使用支持活性成分的各种盖仑样形式的外源性生物区域用于预防和/或治疗性障碍的用途 男性或女性和/或增加性敏感性。
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3.发明申请LIPOSOMAL COMPOSITION COMPRISING AN ACTIVE INGREDIENT FOR RELAXING SMOOTH MUSCLE, THE PRODUCTION OF THIS COMPOSITION AND THE THERAPEUTIC USE THEREOF 有权包含用于放松平滑肌肉的活性成分的脂质组合物，该组合物的生产及其治疗用途公开(公告)号：US20090324698A1
公开(公告)日：2009-12-31
申请号：US11577488
申请日：2005-10-14
IPC分类号： A61K9/127 , A61P15/00 , A61K31/519 , A61K31/4985
CPC分类号： A61K9/127 , A61K9/0034 , A61K9/06 , A61K9/1277 , A61K9/1278
摘要： The invention relates to a pharmaceutical composition made from an active ingredient included in liposomes for topical application, whereby the liposomes have an aqueous medium in the interior thereof and contain at least one active ingredient therein which exerts a direct or indirect relaxing effect on smooth musculature and is preferably selected from the group of prostaglandins, adenylate cyclases, cAMP, AMP, ATP, NO-synthetases, nitrogen monoxide (NO), NO compounds, nitrates, guanylate cyclases, cGMP, GMP, GTP and phosphodiesterases, in particular, Sildenafil. The invention further relates to a method for production of said composition, optionally, in sterile form and the use of the liposomes supporting the active ingredient in various galenic forms for external application in the genital region, for prophylaxis and/or therapy of sexual disorders in men or women and/or for increase of sexual sensitivity.
摘要翻译： 本发明涉及由用于局部应用的脂质体中包含的活性成分制成的药物组合物，其中所述脂质体在其内部具有水性介质并且含有其中的至少一种活性成分，其对平滑肌肉组织施加直接或间接的缓解作用， 优选选自前列腺素，腺苷酸环化酶，cAMP，AMP，ATP，NO-合成酶，一氧化氮（NO），NO化合物，硝酸盐，鸟苷酸环化酶，cGMP，GMP，GTP和磷酸二酯酶，特别是西地那非。 本发明进一步涉及用于生产所述组合物的方法，任选地以无菌形式，以及使用支持活性成分的各种盖仑样形式的外源性生物区域用于预防和/或治疗性障碍的用途 男性或女性和/或增加性敏感性。
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公开(公告)号：US06843942B2
公开(公告)日：2005-01-18
申请号：US10415414
申请日：2001-10-31
CPC分类号： A61K9/1277 , B01J13/02 , Y10T428/2984
摘要： The invention relates to a device for producing lipid vesicles, which is equipped with a line (1) for transporting a polar liquid phase, with a line (2) for transporting an organic liquid phase containing lipids, with a collecting receptacle (7) for accommodating produced lipid vesicles, and with means for conveying the liquid phases through lines (1) and (2). At at least one location, the outer side of line (1) forms a common contact surface with line (2) inside of which a common opening (3) is provided that permits the flow of liquid and joins the inside of line (2) to the inside of line (1). Lines (1) and (2) do not contain agitating or dispersing aids in the area of the opening (3). The invention also relates to a method for the careful production of lipid vesicles, wherein the lipid phase is sprayed under pressure perpendicular to the direction of flow of the polar phase and into the same, whereupon lipid vesicles having a narrow size distribution form spontaneously and without the action of mechanical agitating or dispersing aids.
摘要翻译： 本发明涉及一种用于生产脂质囊泡的装置，其装备有用于输送极性液相的管线（1）和用于输送含有脂质的有机液相的管线（2），其中收集容器（7）用于 容纳产生的脂质囊泡，以及用于通过管线（1）和（2）输送液相的装置。 在至少一个位置处，管线（1）的外侧与管线（2）形成共同的接触表面，内部具有允许液体流动并连接管线（2）内部的公共开口（3） 到线（1）的内部。 线（1）和（2）在开口（3）的区域不包含搅拌或分散助剂。 本发明还涉及一种仔细生产脂质囊泡的方法，其中脂质相在垂直于极性相流动方向的压力下喷雾并进入脂质囊泡，由此自发地形成具有窄尺寸分布的脂质囊泡 机械搅拌或分散助剂的作用。
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5.发明申请公开(公告)号：US20080031935A1
公开(公告)日：2008-02-07
申请号：US11578191
申请日：2005-04-21
申请人： Angelika Bodenteich , Josef Bockmann , Werner Frantsits , Eberhard Pirich , Andreas Wagner , Karola Vorauer-Uhl
发明人： Angelika Bodenteich , Josef Bockmann , Werner Frantsits , Eberhard Pirich , Andreas Wagner , Karola Vorauer-Uhl
IPC分类号： A61K9/127 , A61K31/27 , A61K31/407 , A61K31/435 , A61P25/00 , A61K31/4353 , A61K31/55 , A61K31/661
CPC分类号： A61K9/127
摘要： The invention relates to a pharmaceutical composition based on an active ingredient that is enclosed in liposomes for topical, transdermal application. The interior of said liposomes comprises an acidic, aqueous medium containing at least one cholinesterase inhibitor, preferably from the group containing donepezil, rivastigmine, galantamine, physostigmine, heptylphysostigmine, phenserine, tolserine, cymserine, thiatolserine, thiacymserine, neostigmine, huperzine, tacrine, metrifonate and dichlorvos, or an enantiomer or derivative of at least one of said compounds. In addition, the invention relates to a method for producing said composition, optionally in a sterile form and also to the use of the liposomes charged with the active ingredient in various galenic formulations for topical, transdermal application with a depot effect in the epidermis, for the prophylaxis and/or treatment of cutaneous neuropathic pain or the loss of cutaneous sensory function as a result of neuropathy.
摘要翻译： 本发明涉及一种基于活性成分的药物组合物，其被包封在用于局部，经皮施用的脂质体中。 所述脂质体的内部包含含有至少一种胆碱酯酶抑制剂的酸性水性培养基，优选来自含有多奈哌齐，利凡斯的明，加兰他敏，毒扁豆碱，庚基苯非司明，苯丝氨酸，丝氨酸，胞嘧磺酸，硫蛋白丝氨酸，硫柳汞，新斯的明，石杉碱，他克林， 和二氯葡聚糖，或至少一种所述化合物的对映异构体或衍生物。 此外，本发明涉及任选地以无菌形式生产所述组合物的方法，还涉及在各种盖仑制剂中装载活性成分的脂质体用于在表皮中具有贮库作用的局部，经皮施用的用途， 预防和/或治疗皮肤神经性疼痛或神经病变导致皮肤感觉功能丧失。
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公开(公告)号：US20130315982A1
公开(公告)日：2013-11-28
申请号：US13882344
申请日：2011-10-28
IPC分类号： A61K9/127 , A61K31/155
CPC分类号： A61K9/127 , A61K9/0019 , A61K9/1271 , A61K31/155 , A61K31/785
摘要： A liposomal drug composition comprising: a dimeric or polymeric guanidine derivative or a pharmaceutically acceptable salt thereof as drug substance, and a lipid modified by polyethylene glycole (PEG). The drug composition have cytostatic and antimicrobial activity.
摘要翻译： 一种脂质体药物组合物，其包含：作为药物物质的二聚或聚合的胍衍生物或其药学上可接受的盐，以及由聚乙二醇（PEG）改性的脂质。 药物组合物具有细胞抑制和抗微生物活性。
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公开(公告)号：US20130062301A1
公开(公告)日：2013-03-14
申请号：US13578951
申请日：2011-02-16
申请人： Andreas Wagner
发明人： Andreas Wagner
摘要： A luffing-jib tower crane, comprising a tower and a jib which is connected to the tower via a joint and is held by a luffing cable, wherein the length of the luffing cable can be changed by a drawing-in unit, by the luffing cable being wound onto or unwound from a cable drum of the drawing-in unit, wherein the angle of the jib with respect to the horizontal plane is measured by a first sensor winch is attached to the jib (first angular value), wherein a measuring device measures the length of the unwound part of the luffing cable, from which length the minimum angle of the jib with respect to the horizontal plane (second angular value) can be calculated, and the first angular value can be compared with the second angular value.
摘要翻译： 一种起重臂起重机，包括塔架和起重臂，其通过接头连接到塔架并且由变幅缆绳保持，其中变幅缆线的长度可以通过牵引单元通过变幅 电缆从牵引单元的电缆卷筒卷绕或退绕，其中，起重臂相对于水平面的角度由第一传感器绞盘测量，附接到起重臂（第一角度值），其中测量 装置测量变幅电缆的退绕部分的长度，从该长度可以计算起重臂相对于水平面的最小角度（第二角度值），并且可以将第一角度值与第二角度值进行比较 。
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8.发明申请Tank venting device for a fuel tank of a vehicle, and method for venting a fuel tank 有权用于车辆燃料箱的油箱排气装置，以及用于排出燃料箱的方法公开(公告)号：US20110284125A1
公开(公告)日：2011-11-24
申请号：US13112436
申请日：2011-05-20
申请人： HARALD HAGEN , Andreas Wagner
发明人： HARALD HAGEN , Andreas Wagner
IPC分类号： B67D7/04 , B67D7/36 , G05D7/06 , B60K15/035
CPC分类号： F02M25/089 , B60K15/03519 , B60K2015/03302 , B60K2015/03514 , B60K2015/03576 , F02M37/0076 , Y10T137/264 , Y10T137/86324
摘要： The invention relates to a tank venting system for a fuel tank (12) of a vehicle, having a vent line (14) for discharge of gaseous hydrocarbons from the fuel tank (12) during refueling thereof. Gaseous hydrocarbons originating from the fuel tank (12) can be introduced in a filler pipe (20) of the fuel tank (12) via a recirculation line (24). A control device (34) controls a proportional valve (32) and changes in this way a pass-through cross section of the recirculation line (24). In this way, a load of an activated charcoal filter (16) which is coupled with the vent line (14) can be minimized. The control device (34) can especially determine a pressure in the fuel tank (12). Furthermore, the invention relates to a method of venting a fuel tank (12) during refueling thereof.
摘要翻译： 本发明涉及一种用于车辆的燃料箱（12）的罐排放系统，具有用于在其加油期间从燃料箱（12）排出气态烃的排放管线（14）。 源自燃料箱（12）的气态烃可以经由再循环管线（24）引入燃料箱（12）的加注管（20）。 控制装置（34）控制比例阀（32）并以这种方式改变再循环管线（24）的通过横截面。 以这种方式，能够使与排气管线（14）联接的活性炭过滤器（16）的负载最小化。 控制装置（34）可以特别地确定燃料箱（12）中的压力。 此外，本发明涉及一种在加油期间排放燃料箱（12）的方法。
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公开(公告)号：US20100128072A1
公开(公告)日：2010-05-27
申请号：US12512068
申请日：2009-07-30
申请人： Andreas Wagner
发明人： Andreas Wagner
IPC分类号： B41J29/38
CPC分类号： G07B17/00193 , B41J3/36 , G07B2017/00217
摘要： A universally usable electronic manual stamping device has an inkjet print head that can be moved back and forth in a print window, the print window being arranged in a base plate facing toward a print medium during the printing. A control unit of the device is connected with a user interface, with an external interface and with an internal interface. The inkjet print head is operationally connected via the internal interface with an actuator to move the inkjet print head and with an internal power source to supply the control unit, the inkjet print head and its actuator, as well as the interfaces. The control unit includes a security processor that possesses at least one transaction module which is provided to implement cryptographic security and certification tasks in connection with the printing of an individually secured stamp imprint. The control unit is programmed to control the printing and a base station onto which the manual stamping device is fashioned to be placed for its maintenance and downloading with data.
摘要翻译： 普遍可用的电子手动冲压装置具有能够在打印窗口中来回移动的喷墨打印头，打印窗口在打印期间布置在面向打印介质的基板中。 设备的控制单元与用户界面，外部接口和内部接口连接。 喷墨打印头通过内部接口与致动器可操作地连接以移动喷墨打印头和内部电源，以供应控制单元，喷墨打印头及其致动器以及接口。 该控制单元包括一个安全处理器，该安全处理器具有至少一个交易模块，该交易模块被提供以实现与打印单独保密的印记印记有关的加密安全和认证任务。 控制单元被编程为控制打印以及将手动冲压装置制成的基站放置成用于其维护和下载的数据。
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公开(公告)号：US20060010000A1
公开(公告)日：2006-01-12
申请号：US11172774
申请日：2005-07-01
申请人： Joachim Jauert , Axel Ortmann , Tilmann Schilling , Torsten Schlaaff , Andreas Wagner , Dieter Wolm
发明人： Joachim Jauert , Axel Ortmann , Tilmann Schilling , Torsten Schlaaff , Andreas Wagner , Dieter Wolm
IPC分类号： G06Q99/00
CPC分类号： G07B17/00193 , G07B2017/00233
摘要： An arrangement for installing a communication unit in an apparatus having a security housing, such as a mail processing apparatus, including a cavity bay located at a non-secure region of the apparatus that is accessible by a cover that is non-destructibly detachable from the security housing. The bay receives a pluggable communication unit that has a connection element connectible by a plug-in movement with a connection element of a motherboard located in the secure region of the apparatus: The cavity has at least one further connection element that is electrically conductively and mechanically connected with a metal chassis part of the apparatus in the security housing. This further connection element protrudes into the cavity and establishes contact with the communication unit for grounding thereof.
摘要翻译： 一种用于将通信单元安装在具有诸如邮件处理设备的安全壳体的设备中的装置，该设备包括位于设备的非安全区域的空腔，所述空腔可由不可破坏地拆卸的盖可接近 安全住房。 隔间接收可插拔通信单元，该可插拔通信单元具有通过插入式移动连接的连接元件，该连接元件具有位于该设备的安全区域中的主板的连接元件：空腔具有至少一个导电和机械的另外的连接元件 与安全壳体中的装置的金属底盘部分连接。 该另外的连接元件突出到空腔中并与通信单元建立接触，用于接地。
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