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    Methods of preparing new taxoids and pharmaceutical compositions containing them
    2.
    发明授权
    Methods of preparing new taxoids and pharmaceutical compositions containing them 失效
    制备新紫杉烷和含有它们的药物组合物的方法

    公开(公告)号：US06232477B1

    公开(公告)日：2001-05-15

    申请号：US09528448

    申请日：2000-03-17

    申请人： Hervé Bouchard ,  Jean-Dominique Bourzat ,  Alain Commerçon

    发明人： Hervé Bouchard ,  Jean-Dominique Bourzat ,  Alain Commerçon

    IPC分类号： C07D30514

    CPC分类号： C07D305/14

    摘要： Methods of preparing new taxoids of general formula (I) are presented: in which: R4 represents an alkanoyloxy radical in which the alkanoyl portion contains 2 to 6 carbon atoms in an unbranched or branched chain, this radical unsubstituted or substituted with one or more halogen atoms, an alkoxy radical containing 1 to 4 carbon atoms, or alternatively R4 represents a cycloalkanoyloxy radical in which the cycloalkanoyl portion contains 4 to 8 carbon atoms, or alternatively R4 represents a benzoyloxy radical; R5 represents an alkoxy radical containing 1 to 4 carbon atoms, substituted by an alkylthio radical containing 1 to 4 carbon atoms; and Z represents a hydrogen atom or a radical of general formula:

    摘要翻译： 提供了制备通式（I）的新紫杉烷的方法：其中：R4表示烷酰氧基，其中链烷酰基部分在无支链或支链上含有2-6个碳原子，该未取代的基团或被一个或多个卤素 原子，含有1至4个碳原子的烷氧基，或者R4表示环烷酰氧基，其中环烷酰基部分含有4至8个碳原子，或者R4表示苯甲酰氧基; R5表示含有1至4个碳原子的烷氧基 被含有1至4个碳原子的烷硫基取代; 和Z表示氢原子或通式如下的基团：

    Taxoids, their preparation and pharmaceutical composition containing them
    6.
    发明授权
    Taxoids, their preparation and pharmaceutical composition containing them 失效
    紫杉烷，它们的制备和含有它们的药物组合物

    公开(公告)号：US07074821B1

    公开(公告)日：2006-07-11

    申请号：US08162984

    申请日：1993-12-08

    申请人： Hervé Bouchard ,  Jean-Dominique Bourzat ,  Alain Commercon

    发明人： Hervé Bouchard ,  Jean-Dominique Bourzat ,  Alain Commercon

    IPC分类号： C07D305/00 ,  A61K31/335

    CPC分类号： C07D305/14 ,  Y02P20/55

    摘要： New taxoids of general formula (I), their preparation and pharmaceutical compositions containing them.In general formula (I), Ar represents an aryl radical, R represents a hydrogen atom or an acetyl, alkoxyacetyl or alkyl radical, R1 represents a benzoyl radical or a radical of formula R2—O—CO— in which R2 represents an optionally substituted alkyl radical, an alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl radical. The new products of general formula (I) have a remarkable antitumor activity.

    摘要翻译： 通式（I）的新紫杉烷类，其制备方法和含有它们的药物组合物。 在通式（I）中，Ar表示芳基，R表示氢原子或乙酰基，烷氧基乙酰基或烷基，R 1表示苯甲酰基或式R 2的基团 其中R 2表示任选取代的烷基，烯基，炔基，环烷基，环烯基，双环烷基，苯基或杂环基。 通式（I）的新产品具有显着的抗肿瘤活性。

    Taxoids, their preparation and pharmaceutical compositions containing them
    7.
    发明授权
    Taxoids, their preparation and pharmaceutical compositions containing them 失效
    紫杉烷类，它们的制备方法和含有它们的药物组合物

    公开(公告)号：US06194582B1

    公开(公告)日：2001-02-27

    申请号：US09126590

    申请日：1998-07-31

    申请人： Hervé Bouchard ,  Jean-Dominique Bourzat ,  Alain Commercon

    发明人： Hervé Bouchard ,  Jean-Dominique Bourzat ,  Alain Commercon

    IPC分类号： C07D26304

    CPC分类号： C07D305/14

    摘要： New taxoids of general formula (I), their preparation, and pharmaceutical compounds containing them. In general formula (I), for example, Ar represents an aryl radical, R represents an alkoxyacetyl radical, R1 represents a benzoyl radical or a radical of formula R2—O—CO— in which R2 represents an optionally substituted alkyl radical, an alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl radical. The new products of general formula (I) have a remarkable antitumor activity.

    摘要翻译： 通式（I）的新紫杉烷类，其制备方法和含有它们的药物化合物。在通式（I）中，例如，Ar表示芳基，R表示烷氧基乙酰基，R 1表示苯甲酰基或式 R2-O-CO-，其中R2表示任选取代的烷基，烯基，炔基，环烷基，环烯基，双环烷基，苯基或杂环基。 通式（I）的新产品具有显着的抗肿瘤活性。

    Taxoids, their preparation and pharmaceutical compositions containing them
    8.
    发明授权
    Taxoids, their preparation and pharmaceutical compositions containing them 失效
    紫杉烷类，它们的制备方法和含有它们的药物组合物

    公开(公告)号：US06384071B2

    公开(公告)日：2002-05-07

    申请号：US09759449

    申请日：2001-01-16

    申请人： Hervé Bouchard ,  Jean-Dominique Bourzat ,  Alain Commercon

    发明人： Hervé Bouchard ,  Jean-Dominique Bourzat ,  Alain Commercon

    IPC分类号： A61K31337

    CPC分类号： C07D305/14

    摘要： New taxoids of general formula (I), their preparation, and pharmaceutical compounds containing them. In general formula (I), for example, Ar represents an aryl radical, R represents an alkoxyacetyl radical, R1 represents a benzoyl radical or a radical of formula R2—O—CO— in which R2 represents an optionally substituted alkyl radical, an alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl radical. The new products of general formula (I) have a remarkable antitumor activity.

    摘要翻译： 通式（I）的新紫杉烷类，其制备方法和含有它们的药物化合物。在通式（I）中，例如，Ar表示芳基，R表示烷氧基乙酰基，R 1表示苯甲酰基或式 R2-O-CO-，其中R2表示任选取代的烷基，烯基，炔基，环烷基，环烯基，双环烷基，苯基或杂环基。通式（I）的新产物具有显着的抗肿瘤活性。