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1.发明授权Cytotoxic agents comprising new tomaymycin derivatives and their therapeutic use 有权包含新的茅屋霉素衍生物的细胞毒剂及其治疗用途公开(公告)号：US08404678B2
公开(公告)日：2013-03-26
申请号：US12689797
申请日：2010-01-19
IPC分类号： C07D487/00 , C07D519/00 , A61K31/5517
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention relates to novel tomaymicine derivatives comprising a linker. It also relates to the conjugate molecules that comprise one or more of said tomaymicine derivatives covalently linked to a cell binding agent through a linking group that is present on the linker of the tomaymycin derivative. It also relates to the preparation of the tomaymicine derivatives and of the conjugate molecules.
摘要翻译： 本发明涉及包含连接体的新颖的甲氧基衍生物。 它还涉及包含一种或多种通过存在于茅屋霉素衍生物的接头上的连接基团与细胞结合剂共价连接的所述柚皮苷衍生物的缀合物分子。 它还涉及制备汤姆米明衍生物和共轭分子。
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公开(公告)号：US08163736B2
公开(公告)日：2012-04-24
申请号：US12174195
申请日：2008-07-16
申请人： Laurence Gauzy , Herve Bouchard , Ravi V. J. Chari , Alain Commercon , Robert Zhao , Yonghong Deng , Wei Li
发明人： Laurence Gauzy , Herve Bouchard , Ravi V. J. Chari , Alain Commercon , Robert Zhao , Yonghong Deng , Wei Li
IPC分类号： C07D519/00 , C07D487/00 , A61K31/5517
CPC分类号： C07D487/04
摘要： The present invention is related to new tomaymycin derivatives, their process of preparation and their therapeutic uses.
摘要翻译： 本发明涉及新的茅屋霉素衍生物，其制备方法及其治疗用途。
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3.发明申请CYTOTOXIC AGENTS COMPRISING NEW TOMAYMYCIN DERIVATIVES AND THEIR THERAPEUTIC USE 有权包含新型甲氧嘧啶衍生物及其治疗用途的细胞毒性剂公开(公告)号：US20100316656A1
公开(公告)日：2010-12-16
申请号：US12689797
申请日：2010-01-19
IPC分类号： A61K39/395 , C07D487/04 , A61K31/5517 , C07K16/00 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention relates to novel tomaymicine derivatives comprising a linker. It also relates to the conjugate molecules that comprise one or more of said tomaymicine derivatives covalently linked to a cell binding agent through a linking group that is present on the linker of the tomaymycin derivative. It also relates to the preparation of the tomaymicine derivatives and of the conjugate molecules.
摘要翻译： 本发明涉及包含连接体的新颖的甲氧基衍生物。 它还涉及包含一种或多种通过存在于茅屋霉素衍生物的接头上的连接基团与细胞结合剂共价连接的所述柚皮苷衍生物的缀合物分子。 它还涉及制备汤姆米明衍生物和共轭分子。
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公开(公告)号：US09624166B2
公开(公告)日：2017-04-18
申请号：US13391407
申请日：2010-08-27
申请人： Yonghong Deng , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Jingye Zhou , Joyce A. Sutcliffe , Magnus P. Ronn
发明人： Yonghong Deng , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Jingye Zhou , Joyce A. Sutcliffe , Magnus P. Ronn
IPC分类号： A61K31/65 , A61P31/04 , C07C237/26 , C07C311/08 , C07C307/10 , C07C311/09 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/44 , C07D205/04 , C07D207/12 , C07D207/16 , C07D209/44 , C07D209/52 , C07D211/54 , C07D211/60 , C07D213/70 , C07D213/74 , C07D213/82 , C07D223/06 , C07D231/18 , C07D233/60 , C07D233/84 , C07D295/15 , C07D307/64
CPC分类号： C07C311/08 , C07C237/26 , C07C307/10 , C07C311/09 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/44 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14 , C07C2103/40 , C07C2103/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2603/40 , C07C2603/44 , C07C2603/46 , C07D205/04 , C07D207/12 , C07D207/16 , C07D209/44 , C07D209/52 , C07D211/54 , C07D211/60 , C07D213/70 , C07D213/74 , C07D213/82 , C07D223/06 , C07D231/18 , C07D233/60 , C07D233/84 , C07D295/15 , C07D307/64
摘要： The present invention is directed to a compound represented by Structural Formula (1): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.
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公开(公告)号：US20120135968A1
公开(公告)日：2012-05-31
申请号：US13319298
申请日：2010-05-07
申请人： Chi-Li Chen , Roger B. Clark , Yonghong Deng , Minsheng He , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Magnus Rönn
发明人： Chi-Li Chen , Roger B. Clark , Yonghong Deng , Minsheng He , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Magnus Rönn
IPC分类号： A61K31/65 , C07D207/09 , C07D295/185 , C07D211/14 , C07D211/58 , C07D209/44 , C07D205/04 , C07D295/155 , C07D209/52 , C07D213/56 , C07D207/14 , C07D471/10 , C07D307/22 , C07D307/16 , C07D487/08 , C07D217/20 , C07D279/12 , C07D225/02 , C07D223/14 , C07D223/08 , C07D223/16 , A61P31/04 , C07D295/26 , C07D241/08 , C07D211/62 , C07D401/04 , C07D221/20 , C07D209/42 , C07C237/26
CPC分类号： C07D471/10 , C07C237/26 , C07C275/24 , C07C311/06 , C07C311/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/24 , C07C2602/42 , C07C2602/50 , C07C2603/46 , C07C2603/74 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/14 , C07D207/16 , C07D209/04 , C07D209/14 , C07D209/44 , C07D209/52 , C07D211/14 , C07D211/34 , C07D213/74 , C07D221/20 , C07D223/04 , C07D223/14 , C07D223/32 , C07D261/20 , C07D295/13 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/185 , C07D295/26 , C07D307/22 , C07D401/04 , C07D413/06
摘要： The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.
摘要翻译： 本发明涉及由结构式（I）表示的化合物或其药学上可接受的盐。 结构式I的变量在本文中定义。 还描述了包含结构式I的化合物及其治疗用途的药物组合物。
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公开(公告)号：US20120208788A1
公开(公告)日：2012-08-16
申请号：US13391407
申请日：2010-08-27
申请人： Yonghong Deng , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Jingye Zhou , Joyce A. Sutcliffe , Magnus P. Ronn
发明人： Yonghong Deng , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Jingye Zhou , Joyce A. Sutcliffe , Magnus P. Ronn
IPC分类号： A61K31/65 , A61P31/04 , C07C237/26
CPC分类号： C07C311/08 , C07C237/26 , C07C307/10 , C07C311/09 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/44 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14 , C07C2103/40 , C07C2103/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2603/40 , C07C2603/44 , C07C2603/46 , C07D205/04 , C07D207/12 , C07D207/16 , C07D209/44 , C07D209/52 , C07D211/54 , C07D211/60 , C07D213/70 , C07D213/74 , C07D213/82 , C07D223/06 , C07D231/18 , C07D233/60 , C07D233/84 , C07D295/15 , C07D307/64
摘要： The present invention is directed to a compound represented by Structural Formula (1): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.
摘要翻译： 本发明涉及由结构式（1）表示的化合物或其药学上可接受的盐。 结构式（I）的变量在本文中定义。 还描述了包含结构式（I）的化合物及其治疗用途的药物组合物。
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公开(公告)号：US09315451B2
公开(公告)日：2016-04-19
申请号：US13319298
申请日：2010-05-07
申请人： Chi-Li Chen , Roger B. Clark , Yonghong Deng , Minsheng He , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Magnus Rönn
发明人： Chi-Li Chen , Roger B. Clark , Yonghong Deng , Minsheng He , Louis Plamondon , Cuixiang Sun , Xiao-Yi Xiao , Magnus Rönn
IPC分类号： A61K31/65 , C07C237/26 , C07C275/24 , C07C311/06 , C07C311/19 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/10 , C07D209/04 , C07D209/44 , C07D211/14 , C07D211/34 , C07D213/74 , C07D221/20 , C07D223/04 , C07D223/32 , C07D295/13 , C07D295/15 , C07D295/155
CPC分类号： C07D471/10 , C07C237/26 , C07C275/24 , C07C311/06 , C07C311/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/24 , C07C2602/42 , C07C2602/50 , C07C2603/46 , C07C2603/74 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/14 , C07D207/16 , C07D209/04 , C07D209/14 , C07D209/44 , C07D209/52 , C07D211/14 , C07D211/34 , C07D213/74 , C07D221/20 , C07D223/04 , C07D223/14 , C07D223/32 , C07D261/20 , C07D295/13 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/185 , C07D295/26 , C07D307/22 , C07D401/04 , C07D413/06
摘要： The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.
摘要翻译： 本发明涉及由结构式（I）表示的化合物或其药学上可接受的盐。 结构式I的变量在本文中定义。 还描述了包含结构式I的化合物及其治疗用途的药物组合物。
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