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1.发明授权Inert matrix based on polycaprolactone for the oral administration of a drug, and method for the preparation of the galenic form comprising this matrix 失效用于口服给药的基于聚己内酯的惰性基质，以及制备包含该基质的盖仑型的方法
公开(公告)号：US4629624A
公开(公告)日：1986-12-16
申请号：US686214
申请日：1984-12-26
申请人： Herve Grouiller , Fabien Christ
发明人： Herve Grouiller , Fabien Christ
CPC分类号： A61K9/204 , Y10S514/951
摘要： The present invention relates to a new inert matrix having adjustable porosity and hardness.This matrix comprises polycaprolactone having an average molecular weight of between 2000 and 70,000, which is in the form of agglomerated grains having an average diameter of between 50 and 500 .mu.m and has a degree of crystallinity of at least 75%. The invention relates to the method for the preparation of a porous galenic form by means of the said matrix.
摘要翻译： 本发明涉及一种具有可调孔性和硬度的新的惰性基体。 该基质包含平均分子量为2000〜70,000的聚己内酯，其为平均直径为50〜500μm，结晶度为75％以上的凝聚颗粒的形式。 本发明涉及通过所述基质制备多孔盖仑形式的方法。
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2.发明授权Process of preparation of a new memory thermoplastic composition from polycaprolactone and polyurethane, product obtained by this process and its use particularly in orthopedics 失效从聚己内酯和聚氨酯制备新型记忆热塑性组合物的方法，通过该方法获得的产品及其在骨科中的应用
公开(公告)号：US4912174A
公开(公告)日：1990-03-27
申请号：US803605
申请日：1985-12-02
申请人： Herve Grouiller
发明人： Herve Grouiller
CPC分类号： C08G18/0842 , A61L15/125 , C08L67/04 , C08G2270/00 , C08G2280/00 , Y10S525/903
摘要： A process is disclosed for preparing a thermoplastic composition having elastic memory and containing polyurethane interlocked in a network of polycaprolactone. The product of the aforementioned process is particularly useful as orthopedic cast or immobilizing device.
摘要翻译： 公开了一种制备具有弹性记忆并含有在聚己内酯网络中互锁的聚氨酯的热塑性组合物的方法。 上述方法的产物特别可用作矫形铸造或固定装置。
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3.发明授权Process for preparing a polymer of three-dimensional structure of the cross-linked polyurethane type, product obtained according to this process and application thereof as swelling agent, particularly in therapeutics 失效用于制备交联聚氨酯类型的三维结构聚合物的方法，根据该方法获得的产物及其作为溶胀剂的应用，特别是治疗剂
公开(公告)号：US4340699A
公开(公告)日：1982-07-20
申请号：US278845
申请日：1981-06-29
申请人： Herve Grouiller
发明人： Herve Grouiller
IPC分类号： C08G18/00 , A61K8/72 , A61K8/87 , A61K31/785 , A61L15/26 , A61L15/60 , A61P1/00 , A61Q19/00 , C08G18/08 , C08G18/50 , C08G18/83 , C08G59/00 , C08G59/04 , C08G18/30
CPC分类号： C08G18/833 , A61K31/785 , A61K8/87 , A61L15/26 , A61L15/60 , A61Q19/00 , C08G18/0814
摘要： The present invention relates to a process for preparing a polymer of the cross-linked polyurethane type, whereby(1) the following are reacted:(a) a polyolether, chosen from the group constituted by the oxyalkylene polyols (I) and mixtures thereof, obtained by condensation of a polyol (II) containing at least 2 OH groups and preferably 3 to 6 OH groups with an alkylene oxide (III) at a rate of 1 to 20 moles of (III) per free OH group of (II), and(b) a polyisocyanate (IV),the reaction being effected with an excess of OH groups of (I) with respect to the NCO isocyanate groups of (IV) to obtain a polyurethane-polyol (V) having free OH groups; and(2) the polyurethane-polyol (V) thus obtained is reacted with epichlorhydrin (VI) and a polyamine (VII) chosen from the polyamines having at least two NH.sub.2 amino groups and mixtures thereof. The invention also relates to this polymer as new industrial product and to its application as swelling agent.
摘要翻译： 本发明涉及一种制备交联聚氨酯类聚合物的方法，其中（1）使下列物质反应：（a）选自氧化烯多元醇（I）及其混合物的聚烯烃， 通过使含有至少2个OH基团，优选3〜6个OH基团的多元醇（II）与环氧烷（III）以（ii）的每个游离OH基团为1〜20摩尔（III）的比例缩合得到， 和（b）多异氰酸酯（IV），相对于（IV）的NCO异氰酸酯基，过量的（I）的OH基进行反应，得到具有游离OH基团的聚氨酯 - 多元醇（V） 和（2）由此获得的聚氨酯 - 多元醇（V）与选自具有至少两个NH 2氨基的多胺和其混合物的表氯醇（VI）和多胺（VII）反应。 本发明还涉及这种聚合物作为新的工业产品和它作为溶胀剂的应用。
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