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23 条记录 (耗时 0.029 秒)

    Process for the production of methionine
    2.
    发明授权
    Process for the production of methionine 有权
    生产甲硫氨酸的方法

    公开(公告)号：US06545179B2

    公开(公告)日：2003-04-08

    申请号：US09782416

    申请日：2001-02-13

    申请人： Herve Ponceblanc ,  Jean-Christophe Rossi ,  Phillippe Laval ,  Georges Gros

    发明人： Herve Ponceblanc ,  Jean-Christophe Rossi ,  Phillippe Laval ,  Georges Gros

    IPC分类号： C07C32100

    CPC分类号： C07C319/20 ,  C07C323/52 ,  C07C323/58 ,  C07C323/60

    摘要： A process for the production of methionine which comprises (a) hydrolysing the methionine amide in the presence of a catalyst comprising titanium to produce ammonium methioninate, said catalyst having a porosity of from 5 to 1000 nm, a total pore volume of from 0.2 to 0.55 cm3/g and a surface area of from 30 to 150 m2/g, and (b) a second step of recuperating methionine from the ammonium methioninate salt by removing ammonia. Also claimed is an industrial process for the production of methionine incorporating the aforementioned hydrolysis.

    摘要翻译： 一种生产甲硫氨酸的方法，其包括（a）在包含钛的催化剂存在下水解甲硫氨酰胺以产生甲硫氨酸铵，所述催化剂的孔隙率为5-1000nm，总孔体积为0.2-0.55 cm 3 / g，表面积为30〜150m 2 / g，（b）通过除去氨将来自甲硫氨酸铵盐的甲硫氨酸回收的第二工序。 还要求的是用于生产掺入上述水解的甲硫氨酸的工业方法。

    Process for the preparation of malathion
    8.
    发明授权
    Process for the preparation of malathion 失效
    马拉硫磷的制备过程

    公开(公告)号：US4367180A

    公开(公告)日：1983-01-04

    申请号：US242539

    申请日：1981-03-11

    申请人： Noel Rouy ,  Georges Gros

    发明人： Noel Rouy ,  Georges Gros

    IPC分类号： C07F9/165

    CPC分类号： C07F9/1651

    摘要： Process for the preparation of malathion by reacting O,O-dimethyl-dithiophosphoric acid with ethyl maleate in the presence of a solvent which forms a heterogeneous azeotrope with the O,O-dimethyl-dithiophosphoric acid.

    摘要翻译： 在与O，O-二甲基 - 二硫代磷酸形成非均相共沸物的溶剂的存在下，通过使O，O-二甲基 - 二硫代磷酸与马来酸乙酯反应制备马拉硫磷的方法。

    Cephalosporin derivatives
    9.
    发明授权
    Cephalosporin derivatives 失效
    头孢菌素衍生物

    公开(公告)号：US4034090A

    公开(公告)日：1977-07-05

    申请号：US592096

    申请日：1975-06-30

    申请人： Christian Berger ,  Daniel Farge ,  Georges Gros ,  Mayer Naoum Messer ,  Claude Moutonnier

    发明人： Christian Berger ,  Daniel Farge ,  Georges Gros ,  Mayer Naoum Messer ,  Claude Moutonnier

    IPC分类号： C07D501/06 ,  A61K31/546 ,  C07D257/04 ,  C07D285/12 ,  C07D285/125 ,  C07D285/13 ,  C07D501/20 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  A61K31/545

    CPC分类号： C07D257/04 ,  C07C329/00 ,  C07D285/125 ,  C07D285/13 ,  C07D501/20

    摘要： New cephalosporin derivatives of the formula: ##STR1## in which either (a) R.sub.1 is hydrogen, acetoxy, azido or heterocyclylthio or heterocyclylcarbonylthio which is (1,3,4-thiadiazol-2-yl)-thio which is unsubstituted or substituted by straight or branched chain C.sub.1-4 alkyl or alkoxy, straight or branched chain C.sub.1-4 alkylthio, straight or branched chain C.sub.1-4 alkylsulphonyl, amino or acetylamino; (1,2,3,4-tetrazol-5-yl)-thio which is unsubstituted or substituted in the 1-position by straight or branched chain C.sub.1-4 alkyl, hydroxy straight or branched chain C.sub.1-4 alkyl, phenyl or hydroxyphenyl, or in the 2-position by straight or branched chain C.sub.1-4 alkyl or hydroxy straight or branched chain C.sub.1-4 alkyl; (1,2,4-triazol-3-yl)-thio, (4-methyl-1,3-thiazol-2-yl)-thio, (3-methyl-1,2,4-thiadiazol-5-yl)-thio or (1,2,3-thiadiazol-4-yl)-carbonylthio, and R.sub.2 is carboxy or a radical of the formula: ##STR2## in which the radical: ##STR3## is a radical which can be easily removed enzymatically, and in which R.sub.3 is hydrogen or straight or branched chain C.sub.1-4 alkyl and R.sub.4 is straight or branched chain C.sub.1-4 alkyl or cyclohexyl; or (b) R.sub.1 is a pyridinio ion and R.sub.2 is a carboxylato ion, and pharmaceutically acceptable non-toxic metal salts thereof and addition salts thereof with nitrogen containing bases possess valuable anti-bacterial properties, showing activity against both Gram-positive and Gram-negative bacteria.

    摘要翻译： 下式的新型头孢菌素衍生物：其中（a）R 1是氢，乙酰氧基，叠氮基或杂环基硫基或杂环基羰基硫基，其是未取代的（1,3,4-噻二唑-2-基） - 硫基 直链或支链C 1-4烷基或烷氧基，直链或支链C 1-4烷硫基，直链或支链C 1-4烷基磺酰基，氨基或乙酰氨基; （1,2,3,4-四唑-5-基） - 硫基，其未被取代或在1-位被直链或支链C 1-4烷基取代，羟基直链或支链C 1-4烷基，苯基或羟基苯基 或2-位的直链或支链C 1-4烷基或羟基直链或支链C 1-4烷基; （1,2,4-三唑-3-基） - 硫代，（4-甲基-1,3-噻唑-2-基） - 硫代，（3-甲基-1,2,4-噻二唑-5-基） ） - 硫代或（1,2,3-噻二唑-4-基） - 羰基硫基，并且R 2是羧基或下式的基团：其中基团：（III）是 其可以容易地被酶除去，其中R 3是氢或直链或支链C 1-4烷基，R 4是直链或支链C 1-4烷基或环己基; 或（b）R 1是吡啶鎓离子，R 2是羧基离子，其药学上可接受的无毒金属盐和其与含氮碱基的加成盐具有有价值的抗菌性质，显示出对革兰氏阳性和革兰氏阴性菌的活性， 阴性细菌。

    1,4-Dithiin (and oxathiin)-yl cephalosporin derivatives, and compositions containing them
    10.
    发明授权
    1,4-Dithiin (and oxathiin)-yl cephalosporin derivatives, and compositions containing them 失效
    1,4-二硫辛（和氧硫辛酸） - 基头孢菌素衍生物和含有它们的组合物

    公开(公告)号：US4029781A

    公开(公告)日：1977-06-14

    申请号：US617066

    申请日：1975-09-26

    申请人： Christian Berger ,  Daniel Farge ,  Georges Gros ,  Mayer Naoum Messer ,  Claude Moutonnier

    发明人： Christian Berger ,  Daniel Farge ,  Georges Gros ,  Mayer Naoum Messer ,  Claude Moutonnier

    IPC分类号： C07D501/22 ,  A61K31/546 ,  C03C17/28 ,  C07D501/06 ,  C07D501/20 ,  C07D501/34 ,  A61K31/54

    CPC分类号： C07D501/20 ,  C03C17/28 ,  Y02P20/55

    摘要： New cephalosporin compounds of the formula: ##STR1## in which A is oxygen or sulphur, R.sub.1 is hydrogen or acetoxy and R.sub.2 is carboxy or a radical of the formula: ##STR2## in which the radical ##STR3## is a radical which can be easily removed enzymatically, and in which R.sub.3 is hydrogen or straight or branched chain C.sub.1-4 alkyl and R.sub.4 is straight or branched chain C.sub.1-4, alkyl or cyclohexyl, together with its diastereoisomeric forms and mixtures thereof, its acid addition salts and, where appropriate, its pharmaceutically acceptable non-toxic metal salts and addition salts with nitrogen-containing bases other than ammonia, exhibit valuable anti-bacterial properties, in particular against Gram-positive and Gram-negative bacteria.

    摘要翻译： 下式的新型头孢菌素化合物：其中A是氧或硫，R1是氢或乙酰氧基，R2是羧基或下式的基团：其中基团（I） （III）是可以容易地酶促去除的基团，其中R3是氢或直链或支链C1-4烷基，R4是直链或支链C1-4，烷基或环己基，以及它们的非对映异构形式和混合物 其酸加成盐，并且在适当的情况下，其药学上可接受的无毒金属盐和与氨以外的含氮碱的加成盐显示出有价值的抗菌性质，特别是抗革兰氏阳性和革兰氏阴性菌。