公开(公告)号：US20090082594A1

公开(公告)日：2009-03-26

申请号：US11719122

申请日：2005-11-14

申请人： Hideki Murata ,  Ikuhiro Nakatani ,  Mariko Shitashige ,  Kenji Tajima

发明人： Hideki Murata ,  Ikuhiro Nakatani ,  Mariko Shitashige ,  Kenji Tajima

IPC分类号： C07C229/26

CPC分类号： C07C227/42 ,  C07C229/26

摘要： The present invention provides crystals of L-ornithine and a process for producing the crystals of L-ornithine including the steps of (i) exposing L-ornithine or a salt thereof, a composition comprising L-ornithine or a salt thereof, or a solution containing L-ornithine, a salt thereof, or the composition to a cation exchange resin to adsorb L-ornithine onto the cation exchange resin; (ii) eluting L-ornithine from the cation exchange resin on which L-ornithine is adsorbed with an aqueous alkaline solution, and removing an alkaline component from the resulting eluate to prepare an aqueous L-ornithine solution; and (iii) mixing the aqueous L-ornithine solution with a hydrophilic organic solvent, and crystallizing L-ornithine from the resulting mixed solution.

摘要翻译： 本发明提供L-鸟氨酸的晶体和L-鸟氨酸晶体的制造方法，其特征在于，包括以下步骤：（i）使L-鸟氨酸或其盐，包含L-鸟氨酸或其盐的组合物或溶液 将含有L-鸟氨酸的盐或其组合物或阳离子交换树脂，将L-鸟氨酸吸附到阳离子交换树脂上; （ii）从碱性水溶液中吸附L-鸟氨酸的阳离子交换树脂中洗脱L-鸟氨酸，从得到的洗脱液中除去碱性成分，制备L-鸟氨酸水溶液; 和（iii）将L-鸟氨酸水溶液与亲水性有机溶剂混合，并从所得混合溶液中结晶L-鸟氨酸。

公开(公告)号：US07772280B2

公开(公告)日：2010-08-10

申请号：US11719122

申请日：2005-11-14

申请人： Hideki Murata ,  Ikuhiro Nakatani ,  Mariko Shitashige ,  Kenji Tajima

发明人： Hideki Murata ,  Ikuhiro Nakatani ,  Mariko Shitashige ,  Kenji Tajima

IPC分类号： A61K31/195 ,  C07C227/00 ,  C07C229/00

CPC分类号： C07C227/42 ,  C07C229/26

摘要： The present invention provides crystals of L-ornithine and a process for producing the crystals of L-ornithine including the steps of (i) exposing L-ornithine or a salt thereof, a composition comprising L-ornithine or a salt thereof, or a solution containing L-ornithine, a salt thereof, or the composition to a cation exchange resin to adsorb L-ornithine onto the cation exchange resin; (ii) eluting L-ornithine from the cation exchange resin on which L-ornithine is adsorbed with an aqueous alkaline solution, and removing an alkaline component from the resulting eluate to prepare an aqueous L-ornithine solution; and (iii) mixing the aqueous L-ornithine solution with a hydrophilic organic solvent, and crystallizing L-ornithine from the resulting mixed solution.

摘要翻译： 本发明提供L-鸟氨酸的晶体和L-鸟氨酸晶体的制造方法，其特征在于包括以下步骤：（i）使L-鸟氨酸或其盐，包含L-鸟氨酸或其盐的组合物或溶液 将含有L-鸟氨酸的盐或其组合物或阳离子交换树脂，将L-鸟氨酸吸附到阳离子交换树脂上; （ii）从碱性水溶液中吸附L-鸟氨酸的阳离子交换树脂中洗脱L-鸟氨酸，从得到的洗脱液中除去碱性成分，制备L-鸟氨酸水溶液; 和（iii）将L-鸟氨酸水溶液与亲水性有机溶剂混合，并从所得混合溶液中结晶L-鸟氨酸。

公开(公告)号：US5629180A

公开(公告)日：1997-05-13

申请号：US496098

申请日：1995-06-28

申请人： Tetsuo Nakano ,  Motokazu Nakayama ,  Mariko Shitashige ,  Masato Ikeda ,  Satoru Furukawa

发明人： Tetsuo Nakano ,  Motokazu Nakayama ,  Mariko Shitashige ,  Masato Ikeda ,  Satoru Furukawa

IPC分类号： C12N1/20 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08 ,  C12R1/185 ,  C12R1/19

CPC分类号： C12P13/06 ,  C12P13/04 ,  C12P13/08 ,  C12R1/19

摘要： Disclosed is a process for producing an L-amino acid which comprises culturing a microorganism belonging to the genus Escherichia, having resistance to 2-ketobutyric acid and ability to produce the L-amino acid in a medium until the L-amino acid is accumulated in the medium, and recovering the L-amino acid therefrom.

摘要翻译： 公开了一种L-氨基酸的制备方法，其包括培养属于埃希氏杆菌属的微生物，具有对2-酮丁酸的抗性和在培养基中产生L-氨基酸的能力，直到L-氨基酸被积聚 培养基，并从中回收L-氨基酸。