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    Ruthenium-phosphine complex
    2.
    发明授权
    Ruthenium-phosphine complex 失效
    钌膦络合物

    公开(公告)号：US4764629A

    公开(公告)日：1988-08-16

    申请号：US125280

    申请日：1987-11-25

    申请人： Noboru Sayo ,  Takanao Taketomi ,  Hidenori Kumobayashi ,  Susumu Akutagawa

    发明人： Noboru Sayo ,  Takanao Taketomi ,  Hidenori Kumobayashi ,  Susumu Akutagawa

    IPC分类号： B01J31/24 ,  B01J31/00 ,  C07B61/00 ,  C07F15/00

    CPC分类号： C07F15/0053

    摘要： A ruthenium-phosphine complex represented by formula (I): ##STR1## wherein R represents a hydrogen atom, a methyl group, or a methoxy group; S represents a tertiary amine; when y is 0, then x is 2, z is 4, and p is 1; and when y is 1, then x is 1, z is 1, and p is 0. The complex is inexpensive and exhibits excellent performance as a catalyst for various organic syntheses, and particularly asymmetric hydrogenation.

    摘要翻译： 由式（I）表示的钌膦络合物：其中R表示氢原子，甲基或甲氧基; S表示叔胺; 当y为0时，x为2，z为4，p为1; 当y为1时，x为1，z为1，p为0.该复合物价格便宜，作为各种有机合成催化剂，特别是不对称氢化，表现出优异的性能。

    Iridium-optically active phosphine complex and process for producing optically active alcohols using the same
    4.
    发明授权
    Iridium-optically active phosphine complex and process for producing optically active alcohols using the same 失效
    铱 - 光学活性膦配合物和使用其制备光学活性醇的方法

    公开(公告)号：US5210332A

    公开(公告)日：1993-05-11

    申请号：US856403

    申请日：1992-03-20

    申请人： Takanao Taketomi ,  Susumu Akutagawa ,  Hidenori Kumobayashi ,  Hidemasa Takaya ,  Kazushi Mashima

    发明人： Takanao Taketomi ,  Susumu Akutagawa ,  Hidenori Kumobayashi ,  Hidemasa Takaya ,  Kazushi Mashima

    IPC分类号： C07F15/00

    CPC分类号： C07F15/004

    摘要： An iridium-optically active phosphine complex represented by formula (I):[H.sub.2 Ir(L.sup.1)(L.sup.2)]Y (I)wherein L.sup.1 represents an optically active phosphine compound represented by formula (II): ##STR1## wherein Ar represents a phenyl group or a p- and/or m-lower alkyl-substituted phenyl group, or formula (III): ##STR2## L.sup.2 represents a tertiary phosphine compound represented by formula (IV): ##STR3## wherein Z represents a lower alkoxy group or a di-lower alkylamino group; and A represents an integer of from 1 to 3; Y represents BF.sub.4, PF.sub.6, ClO.sub.4, or BPh.sub.4, wherein Ph represents a phenyl group,and a process for producing an optically active alcohol using the above complex as an enantioselective catalyst are disclosed. The complex exhibits excellent catalytic activity to give high enantioselective yields in enantioselective synthesis, particularly enantioselective hydrogenation.

    摘要翻译： 由式（I）表示的铱光学活性膦配合物：[H2Ir（L1）（L2）] Y（I）其中L1表示由式（II）表示的光学活性膦化合物：其中Ar （III）表示式（IV）表示的叔膦化合物：（IV）表示的叔膦化合物：其中， ）其中Z表示低级烷氧基或二低级烷基氨基; A表示1〜3的整数， Y表示BF4，PF6，ClO4或BPh4，其中Ph表示苯基，并且公开了使用上述络合物作为对映选择性催化剂制备光学活性醇的方法。 复合物显示出优异的催化活性，以在对映选择性合成，特别是对映选择性氢化中提供高对映选择性的产率。

    Ruthenium-phosphine complex
    6.
    发明授权
    Ruthenium-phosphine complex 失效
    钌膦络合物

    公开(公告)号：US4766225A

    公开(公告)日：1988-08-23

    申请号：US130577

    申请日：1987-12-09

    申请人： Noboru Sayo ,  Takanao Taketomi ,  Hidenori Kumobayashi ,  Susumu Akutagawa

    发明人： Noboru Sayo ,  Takanao Taketomi ,  Hidenori Kumobayashi ,  Susumu Akutagawa

    IPC分类号： B01J31/24 ,  C07B61/00 ,  C07C51/36 ,  C07F15/00

    CPC分类号： C07F15/0053 ,  C07C51/36

    摘要： A ruthenium-phosphine complex represented by formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, a methyl group, or a methoxy group; and R.sup.2 represents a lower alkyl group, a halogenated lower alkyl group, a phenyl group, or a phenyl group substituted with a lower alkyl group. The complex is inexpensive and exhibits excellent performance as a catalyst for various organic syntheses, particularly for asymmetric hydrogenation.

    摘要翻译： 由式（I）表示的钌膦络合物：其中R 1表示氢原子，甲基或甲氧基; R 2表示低级烷基，卤代低级烷基，苯基或被低级烷基取代的苯基。 该复合物是便宜的，并且作为各种有机合成的催化剂表现出优异的性能，特别是用于不对称氢化。

    Process for preparing optically active carnitine ester
    8.
    发明授权
    Process for preparing optically active carnitine ester 失效
    制备光学活性肉碱酯的方法

    公开(公告)号：US06197996B1

    公开(公告)日：2001-03-06

    申请号：US08139861

    申请日：1993-10-22

    申请人： Takanao Taketomi ,  Toshiaki Sakaguchi ,  Hidenori Kumobayashi

    发明人： Takanao Taketomi ,  Toshiaki Sakaguchi ,  Hidenori Kumobayashi

    IPC分类号： C07C22900

    CPC分类号： C07C227/32

    摘要： A process for preparing an optically active carnitine ester represented by formula (I): wherein R represents a lower alkyl group; and X represents a halogen atom, is disclosed, comprises asymmetrically hydrogenating a &ggr;-trimethylammonium-3-oxobutanoic ester halide represented by formula (II): wherein R and X are as defined above, in the presence of a ruthenium-optically active phosphine complex as a catalyst. An optically active carnitine ester of any desired isomerism can be obtained through simple operation in high yield at high optical purity. The substrate used is easily available.

    摘要翻译： 一种制备由式（I）表示的光学活性肉碱酯的方法：其中R表示低级烷基; 并且X表示卤素原子，包括在钌光学活性膦配合物存在下不对称地氢化由式（II）表示的γ-三甲基铵-3-氧代丁酸酯卤化物：其中R和X如上所定义 作为催化剂。 可以通过在高光学纯度下以高产率的简单操作获得任何所需异构体的光学活性肉碱酯。 使用的基材很容易获得。

    Process for preparing optically active threonine
    9.
    发明授权
    Process for preparing optically active threonine 失效
    光学活性苏氨酸制备方法

    公开(公告)号：US4906773A

    公开(公告)日：1990-03-06

    申请号：US287434

    申请日：1988-12-21

    申请人： Takanao Taketomi ,  Hidenori Kumobayashi

    发明人： Takanao Taketomi ,  Hidenori Kumobayashi

    IPC分类号： B01J27/185 ,  B01J27/00 ,  C07B61/00 ,  C07C67/00 ,  C07C227/00 ,  C07C227/18 ,  C07C227/20 ,  C07C227/32 ,  C07C229/22 ,  C07C231/18 ,  C07C269/06

    CPC分类号： C07C227/32 ,  C07C231/18 ,  C07C269/06

    摘要： A process for preparing optically active threonine is disclosed, which comprises asymmetrically hydrogenating a 2-N-acylaminoacetoacetic ester represented by formula (I): ##STR1## wherein R.sup.1 represents a lower alkyl group, a phenyl group, a phenyl group substituted with a lower alkyl group or a lower alkoxy group, a benzyl group, or a benzyl group substituted with a lower alkyl group or a lower alkoxy group; R.sup.2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a phenyl group, a phenyl group substituted with a lower alkyl group or a lower alkoxy group, a benzyloxy group, or a benzyloxy group substituted with a lower alkyl group or a lower alkoxy group, in the presence of a ruthenium-optically active phosphine complex as a catalyst to obtain an optically active threonine derivative represented by formula (II): ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, and then hydrolyzing the compound of formula (II). The 2-N-acylaminoacetoacetic ester intermediate can be selectively prepared in a high yield. Either natural type threonine or non-natural type threonine can be prepared selectively by selecting the absolute configuration of the ligand of the ruthenium-optically active phosphine complex.