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    Phosphine compound, complex containing the phosphine compound as ligand, process for producing optically active aldehyde using the phosphine compound or the complex, and 4-[(R)-1'-formylethyl]azetidin-2-one derivatives
    1.
    发明授权
    Phosphine compound, complex containing the phosphine compound as ligand, process for producing optically active aldehyde using the phosphine compound or the complex, and 4-[(R)-1'-formylethyl]azetidin-2-one derivatives 失效
    膦化合物，含膦化合物作为配体的络合物，使用膦化合物或络合物制备旋光醛的方法，以及4 - [（R）-1'-甲酰基乙基]氮杂环丁-2-酮衍生物

    公开(公告)号：US5530150A

    公开(公告)日：1996-06-25

    申请号：US323492

    申请日：1994-10-12

    申请人： Hidemasa Takaya ,  Nozomu Sakai ,  Kyoko Tamao ,  Satoshi Mano ,  Hidenori Kumobayashi ,  Tetsuo Tomita ,  Takao Saito ,  Kazuhiko Matsumura ,  Yasushi Kato ,  Noboru Sayo

    发明人： Hidemasa Takaya ,  Nozomu Sakai ,  Kyoko Tamao ,  Satoshi Mano ,  Hidenori Kumobayashi ,  Tetsuo Tomita ,  Takao Saito ,  Kazuhiko Matsumura ,  Yasushi Kato ,  Noboru Sayo

    IPC分类号： C07F9/02 ,  C07F15/00

    CPC分类号： C07F9/02 ,  C07F15/00

    摘要： A phosphine compound represented by one of the formulas: ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, each represent a phenyl group or a phenyl group substituted with a halogen atom or a lower alkyl group or taken together form a divalent hydrocarbon group; and R.sup.3 and R.sup.4, which may be the same or different, each represent a lower alkyl group, a phenyl group or a phenyl group substituted with a halogen atom, a lower alkyl group or a lower alkoxy group or taken together form a divalent hydrocarbon group, and wherein R.sup.6 and R.sup.6' which may be the same or different, each represent a hydrogen atom, a lower alkyl group or a lower alkoxy group; R.sup.5, R.sup.5', R.sup.11 and R.sup.11' which may be the same or different, each represent a hydrogen atom, a lower alkyl group, a lower alkoxy group or a halogen atom; or a pair of R.sup.5 and R.sup.6 or a pair of R.sup.5' and R.sup.6' may form a ring; R.sup.7 and R.sup.8, which may be the same or different, each represent a phenyl group or a phenyl group substituted with a lower alkyl group, a halogen atom or a lower alkoxy group; and R.sup.9 and R.sup.10, which may be the same or different, each represent a phenyl group or a phenyl group substituted with a lower alkyl group, a lower alkoxy group or a halogen atom; or R.sup.9 and R.sup.10 may be taken together to form a divalent hydrocarbon group.

    摘要翻译： 由下式之一表示的膦化合物：其中R 1和R 2可以相同或不同，各自表示苯基或苯基（III），其中R 1和R 2可以相同或不同， 被卤素原子或低级烷基取代或一起形成二价烃基; 和可以相同或不同的R 3和R 4各自表示低级烷基，苯基或被卤素原子，低级烷基或低级烷氧基取代的苯基或一起形成二价烃基 并且其中可以相同或不同的R6和R6'各自表示氢原子，低级烷基或低级烷氧基; R5，R5'，R11和R11'可以相同或不同，分别表示氢原子，低级烷基，低级烷氧基或卤素原子; 或一对R 5和R 6或一对R 5'和R 6'可以形成环; R 7和R 8可以相同或不同，表示苯基或被低级烷基，卤原子或低级烷氧基取代的苯基; 和R 9和R 10可以相同或不同，各自表示苯基或被低级烷基，低级烷氧基或卤素原子取代的苯基; 或者R 9和R 10可以一起形成二价烃基。

    Iridium-optically active phosphine complex and process for producing optically active alcohols using the same
    2.
    发明授权
    Iridium-optically active phosphine complex and process for producing optically active alcohols using the same 失效
    铱 - 光学活性膦配合物和使用其制备光学活性醇的方法

    公开(公告)号：US5210332A

    公开(公告)日：1993-05-11

    申请号：US856403

    申请日：1992-03-20

    申请人： Takanao Taketomi ,  Susumu Akutagawa ,  Hidenori Kumobayashi ,  Hidemasa Takaya ,  Kazushi Mashima

    发明人： Takanao Taketomi ,  Susumu Akutagawa ,  Hidenori Kumobayashi ,  Hidemasa Takaya ,  Kazushi Mashima

    IPC分类号： C07F15/00

    CPC分类号： C07F15/004

    摘要： An iridium-optically active phosphine complex represented by formula (I):[H.sub.2 Ir(L.sup.1)(L.sup.2)]Y (I)wherein L.sup.1 represents an optically active phosphine compound represented by formula (II): ##STR1## wherein Ar represents a phenyl group or a p- and/or m-lower alkyl-substituted phenyl group, or formula (III): ##STR2## L.sup.2 represents a tertiary phosphine compound represented by formula (IV): ##STR3## wherein Z represents a lower alkoxy group or a di-lower alkylamino group; and A represents an integer of from 1 to 3; Y represents BF.sub.4, PF.sub.6, ClO.sub.4, or BPh.sub.4, wherein Ph represents a phenyl group,and a process for producing an optically active alcohol using the above complex as an enantioselective catalyst are disclosed. The complex exhibits excellent catalytic activity to give high enantioselective yields in enantioselective synthesis, particularly enantioselective hydrogenation.

    摘要翻译： 由式（I）表示的铱光学活性膦配合物：[H2Ir（L1）（L2）] Y（I）其中L1表示由式（II）表示的光学活性膦化合物：其中Ar （III）表示式（IV）表示的叔膦化合物：（IV）表示的叔膦化合物：其中， ）其中Z表示低级烷氧基或二低级烷基氨基; A表示1〜3的整数， Y表示BF4，PF6，ClO4或BPh4，其中Ph表示苯基，并且公开了使用上述络合物作为对映选择性催化剂制备光学活性醇的方法。 复合物显示出优异的催化活性，以在对映选择性合成，特别是对映选择性氢化中提供高对映选择性的产率。

    Process for producing optically active carboxylic acid
    3.
    发明授权
    Process for producing optically active carboxylic acid 失效
    光学活性羧酸的制备方法

    公开(公告)号：US4962230A

    公开(公告)日：1990-10-09

    申请号：US121247

    申请日：1987-11-16

    申请人： Hidemasa Takaya ,  Tetsuo Ohta ,  Ryoji Noyori ,  Noboru Sayo ,  Hidenori Kumobayashi ,  Susumu Akutagawa

    发明人： Hidemasa Takaya ,  Tetsuo Ohta ,  Ryoji Noyori ,  Noboru Sayo ,  Hidenori Kumobayashi ,  Susumu Akutagawa

    IPC分类号： C07C51/36 ,  C07F15/00

    CPC分类号： C07F15/0053 ,  C07C51/36

    摘要： A process for producing an optically active carboxylic acid represented by formula (I): ##STR1## wherein R.sup.1, and R.sup.2, and R.sup.3 each represents a hydrogen atom, an alkyl group, an alkenyl group, or a phenyl or naphthyl group which may have a substituent, provided that all of R.sup.1, R.sup.2, and R.sup.3 are not simultaneously a hydrogen atom; when R.sup.1 and R.sup.2 are simultaneously a hydrogen atom, then R.sup.3 is not a methyl group; and that when R.sup.3 is a hydrogen atom, then R.sup.1 and R.sup.2 are each a group other then a hydrogen atom,is disclosed, comprising asymmetrically hydrogenating an .alpha.,.beta.-unsaturated carboxylic acid represented by formula (II): ##STR2## wherein R.sup.1, R.sup.2, and R.sup.3 are the same as defined above, in the presence of a ruthenium-optically active phosphine complex as a catalyst.According to the process of the invention, the desired optically active carboxylic acids which can be widely used as raw materials for synthesizing various useful compounds, for example, as intermediates for synthesizing physiologically active substances of natural materials and also as liquid crystal materials can be industrially advantageously produced.

    Process for preparing N-acyltetrahydroisoquinoline
    5.
    发明授权
    Process for preparing N-acyltetrahydroisoquinoline 失效
    制备N-酰基四氢异喹啉的方法

    公开(公告)号：US4851537A

    公开(公告)日：1989-07-25

    申请号：US38571

    申请日：1987-04-15

    申请人： Ryoji Noyori ,  Masato Kitamura ,  Hidemasa Takaya ,  Hidenori Kumobayashi ,  Susumu Akutagawa

    发明人： Ryoji Noyori ,  Masato Kitamura ,  Hidemasa Takaya ,  Hidenori Kumobayashi ,  Susumu Akutagawa

    IPC分类号： C07B61/00 ,  B01J31/00 ,  B01J31/24 ,  C07D217/06 ,  C07D217/20

    CPC分类号： C07D217/06 ,  C07D217/20

    摘要： A process for preparing an N-acyltetrahydroisoquinoline represented by formula (II) ##STR1## wherein A represents a phenylene ring substituted with a hydroxyl group, a lower alkoxy group, an acetoxy group, or a benzyloxy group; R represents a hydrogen atom, a lower alkyl group, or a phenyl group; and X represents a hydrogen atoms, a phenyl group, or a phenyl group substituted with a hydroxyl group, a lower alkoxy group, or an acetoxy group, which comprises asymmetrically hydrogenating an N-acyl-1-methylenetetrahydroisoquinoline or N-acyl-1-benzylidenetetrahydroisoquinoline represented by formula (I) ##STR2## wherein A, R, and X are as defined above, in the presence of an optically active ruthenium-phosphine complex as a catalyst. The process exclusively and efficiently provides a useful isomer of the N-acyltetrahydroisoquinoline of high purity which is useful as an intermediate for synthesizing isoquinoline type alkaloids as pharmaceuticals without involving optical resolution of a racemate.

    摘要翻译： 制备由式（II）表示的N-酰基四氢异喹啉的方法其中A表示被羟基，低级烷氧基，乙酰氧基或苄氧基取代的亚苯基环; R表示氢原子，低级烷基或苯基; X表示氢原子，苯基或被羟基，低级烷氧基或乙酰氧基取代的苯基，其包括不对称地氢化N-酰基-1-亚甲基四氢异喹啉或N-酰基-1- 由式（I）表示的亚苄基四氢异喹啉，其中A，R和X如上所定义，在光学活性钌 - 膦配合物作为催化剂存在下进行。 该方法专门有效地提供了高纯度的N-酰基四氢异喹啉的有用异构体，其可用作合成异喹啉类生物碱作为药物而不涉及外消旋物的光学拆分的中间体。